Correlation of phase angle with sarcopenia and its diagnostic value in elderly men with cancer

Ji, Wei; Liu, XiangLiang; Zheng, Kaiwen; Yang, Huajun; Cui, Jiuwei; Li, Wei

doi:10.1016/j.nut.2020.111110

Cited by 24 publications

(35 citation statements)

References 26 publications

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“…[21][22][23][24] The prevalence of sarcopenia in those with a diagnosis of cancer is 16.7%-22.2%. 12,25 In this study, sarcopenia occurred in 15.9% of all enrolled participants, similar to previous studies.…”

Section: Discussionsupporting

confidence: 90%

“…The PhA is known to be decreased in the sarcopenic population, and the prevalence of sarcopenia is reported to be higher in those with lower PhA 11 . In older patients with cancer, lower PhA is reported to be related to lower hand grip strength 10,12 . Similar to previous studies, our results also showed a correlation between the PhA and maximal grip strength.…”

Section: Discussionsupporting

confidence: 90%

“…In those aged >70 years, the mean PhA was 6.19° in men and 5.64° in women 30 . However, the PhA cutoff value for predicting sarcopenia was 4.55° in men and 4.25° in women hospitalized with cardiovascular disease, 7 whereas the PhA cutoff value was 4.25° in men with non‐small cell lung cancer and digestive tract cancer 12 . Moreover, a PhA ≤5.05° predicted sarcopenia in male patients with a cirrhotic liver 13 .…”

Section: Discussionmentioning

confidence: 99%

“…A lower PhA is associated with decreased muscle strength, 10 and PhA is lower in the sarcopenic population. [11][12][13] Moreover, older people with a lower PhA are more likely to experience falls. 14 Although many studies have been performed on the PhA and sarcopenia seen in various diseases, studies of PhA and sarcopenia in patients with prostate cancer are scarce.…”

Section: Introductionmentioning

confidence: 99%

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Bioimpedance phase angle and sarcopenia in older patients with prostate cancer

Park

Lee

et al. 2022

Geriatrics Gerontology Int

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Aim The purpose of this study was to evaluate the factors associated with the bioimpedance phase angle (PhA) in older patients with prostate cancer, and to determine the optimal cutoff for the PhA in patients with sarcopenia and prostate cancer. Methods This retrospective cross‐sectional analysis enrolled patients with prostate cancer aged ≥60 years. Appendicular skeletal muscle mass and PhA estimated by bioimpedance analysis, grip strength, the five‐time chair stand test, gait speed, the Short Physical Performance Battery, the 2‐min walk test and the International Physical Activity Questionnaire Short Form were obtained at enrollment. The diagnosis of sarcopenia was based on the 2019 consensus of the Asian Working Group for Sarcopenia. Results In total, 119 male participants (mean age = 70.7 ± 6.1 years) were available for analysis. A multivariable linear regression model revealed that age, body mass index and the maximal grip strength value were associated with the PhA. The area under the receiver operating characteristic curve value of the PhA for sarcopenia diagnosis was 0.77 (95% confidence interval 0.64–0.90, P < 0.001), with a PhA cutoff value of 4.87°. Conclusions PhA estimated by bioimpedance analysis may be utilized as useful clinical biomarker for reflecting muscle strength and sarcopenia in older patients with prostate cancer. Geriatr Gerontol Int 2022; 22: 623–627.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bioimpedance phase angle and sarcopenia in older patients with prostate cancer

Park

Lee

et al. 2022

Geriatrics Gerontology Int

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show abstract

“…A recent systematic review evaluating 13 studies (7668 subjects) showed a strong correlation between PhA and sarcopenia: PhA is lower in sarcopenic subjects and, in turn, the prevalence of sarcopenia is higher in subjects with a low PhA [23]. An original recent study confirmed that PhA is related to sarcopenia in older men (>65 years of age) with cancer [24]. Given these reasons, PhA appears to be a reliable marker of nutritional status in older patients.…”

Section: Discussionmentioning

confidence: 99%

NutriCatt Protocol Improves Body Composition and Clinical Outcomes in Elderly Patients Undergoing Colorectal Surgery in ERAS Program: A Retrospective Cohort Study

Rinninella

Biondi

Cintoni³

et al. 2021

Nutrients

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Background: A poor body composition, often found in elderly patients, negatively impacts perioperative outcomes. We evaluated the effect of a perioperative nutritional protocol (NutriCatt) on body composition and clinical outcomes in a cohort of elderly patients undergoing colorectal surgery in a high-volume center adopting the ERAS program. Methods: 302 out of 332 elderly (>75 years) patients from 2015 to 2020 were identified. Patients were divided according to their adherence, into “NutriCatt + ERAS” (n = 166) or “standard ERAS” patients (n = 136). Anthropometric and bioelectrical impedance analysis data were evaluated for NutriCatt + ERAS patients. Complications, length of hospital stay (LOS), and other postoperative outcomes were compared between both groups. Results: In NutriCatt + ERAS patients, significant improvements of phase angle (pre-admission vs. admission 4.61 ± 0.79 vs. 4.84 ± 0.85; p = 0.001; pre-admission vs. discharge 4.61 ± 0.79 vs. 5.85 ± 0.73; p = 0.0002) and body cell mass (pre-admission vs. admission 22.4 ± 5.6 vs. 23.2 ± 5.7; p = 0.03; pre-admission vs. discharge 22.4 ± 5.6 vs. 23.1 ± 5.8; p = 0.02) were shown. NutriCatt + ERAS patients reported reduced LOS (p = 0.03) and severe complications (p = 0.03) compared to standard ERAS patients. A regression analysis confirmed the protective effect of the NutriCatt protocol on severe complications (OR 0.10, 95% CI 0.01–0.56; p = 0.009). Conclusions: The NutriCatt protocol improves clinical outcomes in elderly patients and should be recommended in ERAS colorectal surgery.

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Association of phase angle values and sarcopenia in older patients with heart failure

et al. 2023

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Background: Sarcopenia presents an accelerated and accentuated muscle loss in patients with heart failure (HF), leading to a worse prognosis for these patients. This study sought to assess the association of phase angle (PA) values with sarcopenia and its components, as well as to establish a PA cutoff point to predict outcomes such as hospitalization and mortality in older adult patients with HF. Methods: Sarcopenia diagnosis followed the European Working Group on Sarcopenia in Older People criteria. Anthropometric, bioelectrical impedance (PA and body composition), functional capacity and inflammatory markers were assessed.Results: Included patients were predominantly male (67%) and White, with a mean age of 69 ± 7 years, and a predominance of New York Heart Association I and II functional classes (82.1%) and reduced left ventricular ejection fraction (70.8%). Of the total sample, 23.6% were identified as sarcopenic. Mean PA values were lower in patients with sarcopenia (4.9 ± 0.9 and 6.0 ± 0.8°; P < 0.001). The cutoff point detected for sarcopenia in the receiver operating characteristic curve was 5.45°, which is an independent predictor for sarcopenia. PA values below this cutoff point were also associated with each of the sarcopenic components evaluated. PA proved to be an independent predictor for hospitalization (P = 0.042) in the entire sample studied. Conclusion: PA is associated with diagnostic components of sarcopenia and the cutoff point 5.45°proved to be an independent predictor of sarcopenia and hospitalization >3 years in older adult patients with HF.

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Correlation of phase angle with sarcopenia and its diagnostic value in elderly men with cancer

Cited by 24 publications

References 26 publications

Bioimpedance phase angle and sarcopenia in older patients with prostate cancer

Bioimpedance phase angle and sarcopenia in older patients with prostate cancer

NutriCatt Protocol Improves Body Composition and Clinical Outcomes in Elderly Patients Undergoing Colorectal Surgery in ERAS Program: A Retrospective Cohort Study

Association of phase angle values and sarcopenia in older patients with heart failure

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