Correlation of Peritumoral Brain Edema with Morphological Characteristics and Ki67 Proliferative Index in Resected Intracranial Meningiomas

Bečulić, Hakija; Skomorac, Rasim; Jusić, Aldin; Alić, Fahrudin; Mašović, Anes; Burazerović, Eldin; Omerhodžić, Ibrahim; Dorić, Mirsad; Imamović, Melica; Mekić–Abazović, Alma; Efendić, Alma; Udovčić-Gagula, Dalma

doi:10.20471/acc.2019.58.01.06

Cited by 13 publications

(20 citation statements)

References 22 publications

(49 reference statements)

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“…P value was calculated to be 0.014 indicating strong correlation between PTBE and Ki67 index (Table 4). [31]. We also found no statistically significant relationship between the tumor volume and PTBE and/or gender, the different results encountered in multiple papers may further enhance the hypothesis that other multiple factors rather than volume that contribute to PTBE development.…”

Section: Tumor Volume Ptbe and Ki67 Indexmentioning

confidence: 48%

“…Kim B-W et al, found in their study on 86 patients with meningiomas that higher Ki-67 antigen indices lead to a higher frequency of PTBE [12], which is in agreement with our findings. Other studies also showed a strong correlation between PTBE and Ki67 indices [24] [30] [31] [42] but due to limitations and multiple factors that influence PTBE, further research on larger group of patients and longer follow up periods may be required to conclusively determine the definite relationship.…”

Section: Tumor Volume Ptbe and Ki67 Indexmentioning

confidence: 99%

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Ki67 Proliferative Index and Peritumoral Brain Edema in Meningiomas: Do They Correlate? A Clinical Study on 56 Patients

Imam¹,

Elghriany²,

Elshanawany³

et al. 2019

OJMN

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Introduction: Meningiomas are the most common type of extra-axial neoplasm. Peritumoral brain edema (PTBE) can be seen around meningiomas while it may be absent in others. Despite that Ki67 proliferative index has been previously correlated with meningioma grades, no definite relationship has been established in relation to PTBE in meningioma patients. Objective: Correlate the peritumoral brain edema with the Ki67 proliferative index of meningiomas. Patients & Methods: Aclinical prospective study was conducted on 56 patients (47 women, 9 men; mean age 50.89 ± 12.55 years) diagnosed with meningiomas. All patients were evaluated regarding the presence of brain edema surrounding the lesion in pre-operative neuroimaging using T2W and FLAIR MR images. Immunohistochemical staining of Ki67 index (representing proliferative activity) was done. Correlation between presence of PTBE and Ki67 index values was evaluated. Results: PTBE was found in nearly half of the patients (48.2%), while the remaining (51.8%) of patients did not exhibit PTBE in their pre-operative neuroimaging. The mean value of Ki67 index in meningioma patients with PTBE was 4.83% compared to a value of 1.83% in patients without PTBE, P value = 0.014. Conclusion: High Ki67 indices are evident in meningiomas with surrounding peritumoral brain edema (PTBE).

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Section: Tumor Volume Ptbe and Ki67 Indexmentioning

confidence: 48%

Section: Tumor Volume Ptbe and Ki67 Indexmentioning

confidence: 99%

Ki67 Proliferative Index and Peritumoral Brain Edema in Meningiomas: Do They Correlate? A Clinical Study on 56 Patients

Imam¹,

Elghriany²,

Elshanawany³

et al. 2019

OJMN

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“…PTBE is a consequence of high rates of angiogenesis in rapidly growing tumors and tissue hypoxia. 12 PTBE has also been associated with increased risk of recurrence, 36 increased Ki-67 proliferative index, 37 and worse postoperative cognitive functioning 38 and KPS. 39 Meningiomas are highly vascularized tumors and, thus, potentially amenable to antiangiogenic therapy.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Bevacizumab in High-Grade Meningiomas: A Retrospective Clinical Study

Bai¹,

Liu²,

Wen³

2022

NDT

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Objective We investigated the role of bevacizumab (BV) in high-grade meningiomas (HGMs) by retrospective analysis. Methods We retrospectively analyzed the clinical data of 139 patients with HGMs. The chi-square test was used to compare progression-free survival (PFS) and overall survival (OS) between patients who received BV and those who did not. According to whether they received BV treatment, we divided the patients into the BV group and non-BV group, and the effect of BV on PFS and OS was compared. In addition, we compared Karnofsky performance status (KPS) and steroid doses between the BV and non-BV groups. Results There were statistically differences in PFS and OS between the BV and non-BV groups at 12 and 36 months after surgery (P<0.05). However, there was no significant difference in PFS and OS between the two groups at 60 months postoperatively (P>0.05). Using survival curves drawn by the Kaplan Meier method, we found that the PFS and OS of the BV group were greater than those of the non-BV group, and the difference was statistically significant (P<0.05). Conclusion BV could improve PFS and OS at 12 and 36 months after surgery in patients with HGMs. In addition, BV was associated with lower preoperative steroid use.

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“…24,25 While a few studies have shown significant findings correlating PTBE with histological grade especially of WHO grade II and grade III and uncommon variants of WHO grade I meningiomas. [26][27][28][29][30] Moreover, number of studies also showed that of the several types of WHO grade I meningiomas, meningothelial, transitional and secretory variants had a higher tendency to produce PTBE. 27,29,[31][32][33] Further, in this study after a yearly follow up for a period of 4 years it was found that 10 cases recurred.…”

Section: Discussionmentioning

confidence: 99%

The role of peritumoural brain edema in ascertaining the high risk meningiomas

et al. 2020

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Background: Meningiomas are benign tumours which possess a potential to recur. Peritumoural brain edema (PTBE) has been associated with several complications and future recurrence. This study aims to establish the relation of PTBE in different histopathological grades and subtypes of meningiomas and in addition determines the significance of PTBE in ascertaining tumour recurrence. Methods: Complete surgical resection samples from 50 meningioma patients were obtained from the neurosurgical department and histopathologically processed. CT (computerised tomography) scans were used for ascertaining the tumour site and PTBE. Patients were followed up yearly for 4years. Recurrent cases were surgically resected and histologically typed.Results: Meningiomas were more common in the females (70%) than males (30%). PTBE was found in 56% of the cases. 62% were <50 years of age. No significant association was found between gender or age and PTBE. Cerebral convexity was the most common site (56%). 48.8% of grade I meningiomas (p<0.05) and 100% of grade II and grade III meningiomas showed PTBE. Yearly follow up for 4 years showed 10 cases to recur. 90% of these had evidence of PTBE on their pre-operative CT scans. These results were statistically significant (Z=11.31, p<0.001). Conclusions: Meningiomas are mostly benign entities. However, some histological subtypes possess a potential to recur and invade. It has been found that cases showing radiological evidence of PTBE are at a high risk. Hence, follow up of such cases is essential to improve patient survival.

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Correlation of Peritumoral Brain Edema with Morphological Characteristics and Ki67 Proliferative Index in Resected Intracranial Meningiomas

Cited by 13 publications

References 22 publications

Ki67 Proliferative Index and Peritumoral Brain Edema in Meningiomas: Do They Correlate? A Clinical Study on 56 Patients

Ki67 Proliferative Index and Peritumoral Brain Edema in Meningiomas: Do They Correlate? A Clinical Study on 56 Patients

Efficacy of Bevacizumab in High-Grade Meningiomas: A Retrospective Clinical Study

The role of peritumoural brain edema in ascertaining the high risk meningiomas

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