Correlation of peripheral Th17 cells and Th17-associated cytokines to the severity of carotid artery plaque and its clinical implication

Liu, Zhendong; Lu, Fanghong; Pan, Hui; Zhao, Yingxin; Wang, Shujian; Sun, Shenghua; Li, Jun; Hu, Xiaoliang; Wang, Lin

doi:10.1016/j.atherosclerosis.2011.12.026

Cited by 58 publications

(31 citation statements)

References 31 publications

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“…Numbers of studies had reported that Th17 related cytokines was up-regulated in atherosclerosis [13,14]. Consistent with these results, our study found that mRNA of Th17 related cytokines (IL-6, IL-23, IL-1β, IL-17, IL-22 and TNF-α) were increased in atherosclerotic artery specimens than which in normal vessels (Fig.…”

Section: Resultssupporting

confidence: 82%

“…Th17-mediated inflammation has been confirmed to link with many autoimmune diseases, such as rheumatoid arthritis (RA), human psoriasis and inflammatory bowel diseases [8,16]. Although atherosclerosis is characterized by chronic dysregulated Th1 inflammation in the lesion, there are some evidences that Th17 inflammation also involved in atherosclerosis [14,17,18]. The frequency of Th17 cells and Th17 related cytokines are increased in local atherosclerotic lesion as well as in the peripheral circulation of patients with atherosclerosis, including patients with carotid artery plaques and acute coronary syndrome [14,18].…”

Section: Discussionmentioning

confidence: 99%

“…CD4 + T cells in lesion thus grouped as Th1, Th2, and Th17 cell subsets. While Th1 and Th17 inflammatory response have been confirmed to be pro-atherosclerosis, Th2 inflammation seems to be little impact on atherosclerosis [1,2]. Thus, to elucidate how to regulate and influence the specific immune cells and general immune paradigms, such as Th1, Th2 and Th17 in atherosclerosis is fundamental important.…”

Section: Introductionmentioning

confidence: 99%

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Thymic Stromal Lymphopoietin Over-Expressed in Human Atherosclerosis: Potential Role in Th17 Differentiation

Lin

Chang

Dong

et al. 2013

Cell Physiol Biochem

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Background: Adaptive immunity plays a critical role in atherosclerosis and T helper 17 (Th17) cells, a new T-cell lineage, are recently reported to be involved in atherosclerosis. However, the mechanism underlying Th17 inflammation in atherosclerosis remains largely unknown. Thymic stromal lymphopoietin (TSLP) is a novel IL-7-like cytokine and mainly responsible for Th2 inflammation in many inflammatory diseases. Methods and Results: Immunohistochemistry showed that TSLP over-expressed in human atherosclerotic lesion and could be induced by ox-LDL in human vascular smooth muscle cells (HVSMCs) and human umbilical vein endothelial cells (HUVECs). TSLP, in turn, could activate dendritic cells (DCs) to differentiate Th17 inflammation in naive CD4⁺ T cells. Conclusion: TSLP induced by ox-LDL could promote Th17 immune response in vitro, which may be implicated in Th17 inflammation in atherosclerosis.

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Section: Resultssupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Thymic Stromal Lymphopoietin Over-Expressed in Human Atherosclerosis: Potential Role in Th17 Differentiation

Lin

Chang

Dong

et al. 2013

Cell Physiol Biochem

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“…In mouse models for atherosclerosis, the role of IL-17 in different stages of atherosclerosis development has been debated with somewhat conflicting data depending on model used. [37][38][39] However, in human atherosclerosis, the Th17 phenotype 40 and, in our previous studies, a Th1 type of cytokine profile was dominant in advanced atherosclerotic plaques 1 and in vulnerable plaques. 41 Of note, human plaque rupture (leading to cardiovascular disease) does not seem to be fully mimicked in the published mouse models.…”

mentioning

confidence: 72%

Induction of Dendritic Cell–Mediated T-Cell Activation by Modified but Not Native Low-Density Lipoprotein in Humans and Inhibition by Annexin A5

Liu

Ming

Fiskesund

et al. 2015

ATVB

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Objective— Atherosclerosis is an inflammatory disease, where activated immunocompetent cells, including dendritic cells (DCs) and T cells are abundant in plaques. Low-density lipoprotein modified either by oxidation (oxLDL) or by human group X-secreted phospholipase A2 (LDLx) and heat shock proteins (HSP), especially HSP60 and 90, have been implicated in atherosclerosis. We previously reported that Annexin A5 inhibits inflammatory effects of phospholipids, decreases vascular inflammation and improves vascular function in apolipoprotein E −/− mice. Here, we focus on the LDLx effects on human DCs and T cells. Approach and Results— Human DCs were differentiated from peripheral blood monocytes, stimulated by oxLDL or LDLx. Naive autologous T cells were cocultured with pretreated DCs. oxLDL and LDLx, in contrast to LDL, induced DC-activation and T-cell proliferation. T cells exposed to LDLx-treated DCs produced interferon-γ, interleukin (IL)-17 but not IL-4 and IL-10. Annexin A5 abrogated LDLx effects on DCs and T cells and increased production of transforming growth factor-β and IL-10. Furthermore, IL-10 producing T cells suppressed primary T-cell activation via soluble IL-10, transforming growth factor-β, and cell–cell contact. Lentiviral-mediated shRNA knock-down HSP60 and 90 in DCs attenuated the effect of LDLx on DCs and subsequent T-cell proliferation. Experiments on DC and T cells derived from carotid atherosclerotic plaques gave similar results. Conclusions— Our data show that modified forms of LDL such as LDLx but not native LDL activate human T cells through DCs. HSP60 and 90 contribute to such T-cell activation. Annexin A5 promotes induction of regulatory T cells and is potentially interesting as a therapeutic agent.

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“…28,31 CD4 + T cells can be differentiated in several subtypes, including Th1, Th2, Th17, and regulatory T cells (Tregs); of these, Th1 and Th17 have been reported to promote proatherogenic effects. 32,33 Tregs are CD4 + CD25 + cells whose main function is to block the excessive response of the other T-cell subtypes. 33 Tregs can inhibit by direct cell-to-cell contact or by secreting anti-inflammatory cytokines, including TGF-b1, which can also stimulate the differentiation of CD4 + cells into Tregs.…”

Section: Adaptive Immunity and Atherosclerosismentioning

confidence: 99%

Amelioration of Atherosclerosis by the New Medicinal Mushroom Grifola gargal Singer

Harada

D’Alessandro-Gabazza

Toda

et al. 2015

Journal of Medicinal Food

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The beneficial effects of edible mushrooms for improving chronic intractable diseases have been documented. However, the antiatherogenic activity of the new medicinal mushroom Grifola gargal is unknown. Therefore, we evaluated whether Grifola gargal can prevent or delay the progression of atherosclerosis. Atherosclerosis was induced in ApoE lipoprotein-deficient mice by subcutaneous infusion of angiotensin II. Grifola gargal extract (GGE) was prepared and intraperitoneally injected. The weight of heart and vessels, dilatation/atheroma formation of thoracic and abdominal aorta, the percentage of peripheral granulocytes, and the blood concentration of MCP-1/CCL2 were significantly reduced in mice treated with GGE compared to untreated mice. By contrast, the percentage of regulatory T cells and the plasma concentration of SDF-1/CXCL12 were significantly increased in mice treated with the mushroom extract compared to untreated mice. In vitro, GGE significantly increased the secretion of SDF-1/CXCL12, VEGF, and TGF-b1 from fibroblasts compared to control. This study demonstrated for the first time that Grifola gargal therapy can enhance regulatory T cells and ameliorate atherosclerosis in mice.

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Correlation of peripheral Th17 cells and Th17-associated cytokines to the severity of carotid artery plaque and its clinical implication

Cited by 58 publications

References 31 publications

Thymic Stromal Lymphopoietin Over-Expressed in Human Atherosclerosis: Potential Role in Th17 Differentiation

Thymic Stromal Lymphopoietin Over-Expressed in Human Atherosclerosis: Potential Role in Th17 Differentiation

Induction of Dendritic Cell–Mediated T-Cell Activation by Modified but Not Native Low-Density Lipoprotein in Humans and Inhibition by Annexin A5

Amelioration of Atherosclerosis by the New Medicinal Mushroom Grifola gargal Singer

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