Correlation of oxidative stress-related biomarkers with postmenopausal osteoporosis: a systematic review and meta-analysis

Zhao, Fulong; Guo, Lijuan; Wang, Xuefei; Zhang, Yakui

doi:10.1007/s11657-020-00854-w

Cited by 57 publications

(42 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous findings demonstrate the detrimental effect of OS on bone health [33][34][35]. ROS are thought to affect the bone environment via two modes of action.…”

Section: Os and Opmentioning

confidence: 99%

Role of Exosomal MicroRNAs and Their Crosstalk with Oxidative Stress in the Pathogenesis of Osteoporosis

Lü

Zhang

Liang

et al. 2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Osteoporosis (OP) is an aging-related disease involving permanent bone tissue atrophy. Most patients with OP show high levels of oxidative stress (OS), which destroys the microstructure of bone tissue and promotes disease progression. Exosomes (exos) help in the delivery of microRNAs (miRNAs) and allow intercellular communication. In OP, exosomal miRNAs modulate several physiological processes, including the OS response. In the present review, we aim to describe how exosomal miRNAs and OS contribute to OP. We first summarize the relationship of OS with OP and then detail the features of exos along with the functions of exo-related miRNAs. Further, we explore the interplay between exosomal miRNAs and OS in OP and summarize the functional role of exos in OP. Finally, we identify the advantages of exo-based miRNA delivery in treatment strategies for OP. Our review seeks to improve the current understanding of the mechanism underlying OP pathogenesis and lay the foundation for the development of novel theranostic approaches for OP.

show abstract

“…Previous findings demonstrate the detrimental effect of OS on bone health [33][34][35]. ROS are thought to affect the bone environment via two modes of action.…”

Section: Os and Opmentioning

confidence: 99%

Role of Exosomal MicroRNAs and Their Crosstalk with Oxidative Stress in the Pathogenesis of Osteoporosis

Lü

Zhang

Liang

et al. 2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…(Table 3.3.1) Accordingly, a study 22 conducted in Sanliurfa, Turkey, and a middle-European study 23 revealed that serum TOS levels were significantly higher in postmenopausal women. Additionally, Zhao et al 24 recently reviewed 36 studies from different regions, and as a result overall of their investigation, they claimed that there were no statistically significant differences in TOS levels of postmenopausal women with osteoporosis compared to healthy controls.…”

Section: Tos Levels In Postmenopausal Versus Fertile Women (H 01 )mentioning

confidence: 99%

Serum Levels of Oxidative Stress Parameters in Postmenopausal Versus Fertile Women of Kutahya City, Turkey

Erdoğdu

Yöntem

Koçak³

et al. 2021

GJMS

View full text Add to dashboard Cite

Background: Decreased concentration of both oestrogen hormone and vitamin D in postmenopausal period may lead to oxidative stress, lipid peroxidation, dyslipidaemia, osteoporosis, and cardiovascular diseases. The objectives of this study were to determine and compare the serum levels of oxidative stress parameters; TOS, TAS, OSI, PON-1, ARYL in postmenopausal and fertile women of Kutahya city, Turkey. Materials & Methods: This cross-sectional study was conducted at Department of Biochemistry, Faculty of Medicine, Kutahya University of Health Sciences, Kutahya, Turkey from July, 2016 to December, 2016. Kutahya is a city in western Turkey, with population of 237,804 as per 2011 estimates. Two samples were drawn from this population with consecutive technique. Study group included 40 menopausal women, while control group included 40 healthy fertile women. After overnight fasting, venous blood samples were collected, centrifuged, aliquoted into a polystyrene tube, and aliquots were stored at -80°C until measurement for total oxidant status (TOS), total antioxidant status (TAS), paraoxonase-1 (PON-1), and arylesterase (ARYL) measurements were made. Levels of TOS, TAS, OSI, PON-1, ARYL were five research variables on ratio scale. ‘Normal’ data were described by mean, range and SD and skewed data by median, Q1, Q3 and IQR with 95% confidence intervals. For normal data, independent-samples t-test and for skewed data Mann–Whitney U test was used for hypotheses testing. Results: Serum total oxidant status (TOS) and oxidative stress index (OSI) levels were significantly higher (p-value .015 & .003 respectively), and serum paraoxonase-1 (PON-1) and arylesterase (ARYL) levels were significantly lower in postmenopausal than fertile women (p-value <.0001 & .0005 respectively), with no statistical difference for serum total antioxidant status (TAS) levels between the two groups (p-value .186). Conclusion: Postmenopausal period is associated with oxidative stress and decreased antioxidant defence. HDL-c-dependent PON-1 and ARYL activities are also reducing due to a decrease of HDL-c with menopause. Elevated levels of TOS and OSI, decreased levels of PON-1 and ARYL may lead to various life-threatening diseases such as cardiovascular disorders or cancer.

show abstract

“… 21 Meanwhile, other reports illustrate a correlation between osteoporosis and oxidative stress, which may express a higher level compared to a healthy condition. 22 , 23 Oxidative stress is caused by overproduction of reactive oxygen species (ROS) and lack of adequate antioxidants. 22 ROS are highly active molecules known for their dual roles as either detrimental or favorable to the biological system.…”

Section: Introductionmentioning

confidence: 99%

Study on the Local Anti-Osteoporosis Effect of Polaprezinc-Loaded Antioxidant Electrospun Membrane

Gao¹,

Al-Baadani²,

Wu³

et al. 2022

IJN

View full text Add to dashboard Cite

Background: Compared with the healthy condition, osteoporotic bone defects are often accompanied by poor osteogenesis and excessive reactive oxygen species (ROS), which pose serious challenges to bone augmentation and repair by normal resorbable guided bone regeneration (GBR) membrane. Purpose: Polaprezinc (PZ) was loaded into polycaprolactone/gelatin (PG) hybrid electrospun nanofibers to fabricate a GBR membrane with antioxidant and osteogenesis ability. Methods: A series of physicochemical characterization were performed by scanning electron microscopy, Fourier-transform infrared spectroscopy, and water contact angle measurement. In addition to membrane degradation and PZ release detection, membranes were tested for cell viability, differentiation, and protein expression in MC3T3-E1 cells by CCK8, alkaline phosphatase activity, mineralization, and Western blotting assays. The membrane osteogenic capacity in cranial bone defects was studied by micro-CT in vivo. Results: PZ was successfully doped into the PCL/GEL nanofibers to form a hydrophilic GBR membrane. The cumulative release of PZ was closely related to the membrane degradation behavior. PG/0.4%PZ membranes produced the best protective effect on cell proliferation/differentiation under oxidative stress microenvironment; however, the PG/0.8% PZ membrane was cytotoxic. Western blotting demonstrated that the PZ-loaded membrane upregulated the Nrf2/HO-1/SOD1 signaling molecules in a concentration-dependent manner. In addition, micro-CT results showed an abundant formation of new bones in the PG/0.4%PZ group compared to the PG group. Conclusion: PZ-loaded degradable PG membranes (especially PG/0.4%PZ) have great potential to accelerate bone regeneration in oxidative stress-related diseases.

show abstract

Correlation of oxidative stress-related biomarkers with postmenopausal osteoporosis: a systematic review and meta-analysis

Cited by 57 publications

References 55 publications

Role of Exosomal MicroRNAs and Their Crosstalk with Oxidative Stress in the Pathogenesis of Osteoporosis

Role of Exosomal MicroRNAs and Their Crosstalk with Oxidative Stress in the Pathogenesis of Osteoporosis

Serum Levels of Oxidative Stress Parameters in Postmenopausal Versus Fertile Women of Kutahya City, Turkey

Study on the Local Anti-Osteoporosis Effect of Polaprezinc-Loaded Antioxidant Electrospun Membrane

Contact Info

Product

Resources

About