Correlation of oxidative stress and inflammatory markers with the severity of sickle cell nephropathy

Emokpae, Mathias Abiodun; Uadia, Patrick; Gadzama, AA

doi:10.4103/1596-3519.68363

Cited by 30 publications

(34 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Oxidative damage is due to redox imbalance between production of reactive oxygen species (ROS) and the countering effects of the various antioxidants in the body. The increased production of ROS in SCD can be grossly amplified in response to a variety of pathophysiological conditions including renal disorders, inflammation, immunologic disorders, hypoxia, metabolism of drugs or alcohol, and deficiency in antioxidant enzymes [1, 4, 15]. Reactive oxygen species can cause significant damage to biomolecules since membrane lipids readily react with ROS resulting in lipid peroxidation [16–18].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association of Oxidative Stress Markers with Atherogenic Index of Plasma in Adult Sickle Cell Nephropathy

Emokpae

Uadia

2012

Anemia

View full text Add to dashboard Cite

This paper evaluates the association of oxidative stress and atherogenic index of plasma in order to assess the cardiovascular risk in Sickle cell nephropathy especially as lipoprotein levels are lower in SCD than non-SCD patients. Antioxidant enzymes, malondialdehyde(MDA), urea, creatinine, and glomerular filtration rate were evaluated in 110 confirmed sickle cell disease patients: 65 males in steady state, aged21.1±6.0years, 30 males with macroalbuminuria, aged24.5±7.0, years and 15 with chronic kidney disease (CKD), aged31.8±2.0years. The mean activity levels of glutathione peroxidase (GPx), superoxide dismutase (Cu/ZnSOD), and catalase (CAT) were significantly lower (P<0.001) in SCD with macroalbuminuria and CKD while MDA was higher (P<0.001) in SCD with macroalbuminuria and CKD compared with controls. There was negative correlation between GPx (P<0.001), Cu/ZnSOD (P<0.02), and Atherogenic index of plasma in SCD with CKD, while MDA shows a positive correlation (P<0.001) with AIP in SCD with CKD. There was however no correlation between CAT and AIP. Decreased activity levels of antioxidant enzymes and low HDL-cholesterol concentration were confirmed in adult SCD with CKD in Nigerians. The increase oxidative stress and high atherogenic index in CKD may accelerate the process of cardiovascular complications in adult SCD patients. Atherogenic index of plasma was negatively correlated with antioxidant enzymes and positively with MDA.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Sickle cell disease (SCD) is a haemoglobinopathy which is characterized by red blood cell rigidity, compromised perfusions, and tissue infarction [1]. The kidney of patients with SCD is affected both by haemodynamic changes of chronic and by consequences of vaso-occlusion within the renal medulla [2, 3].…”

Section: Introductionmentioning

confidence: 99%

Association of Oxidative Stress Markers with Atherogenic Index of Plasma in Adult Sickle Cell Nephropathy

Emokpae

Uadia

2012

Anemia

View full text Add to dashboard Cite

show abstract

“…In addition, LCAT deficiency can in part, account for elevated serum free cholesterol, reduced HDL/total cholesterol and elevated pre -HDL in CRF. The latter can in turn depress lipolytic activity and hinder triglyceriderich lipoprotein clearance in CRF (Vaziri et al, 2001;Emokpae et al,2010a). Statistically significant decrease in LCAT and lipoprotein lipase (LPL) activities were observed in SCA subjects in steady state compared with HbAS and HbAA controls in both males and females.…”

Section: Pathogenesis Of Lipoprotein Abnormalities In Chronic Kidney mentioning

confidence: 99%

“…Proteinuria as observed in SCA patients with renal insufficiency may act in synergy with oxidative stress and inflammation to initiate and accelerate the progression of renal disease. Chronic exposure of renal tubular epithelium to high levels of filtered plasma proteins may cause tissue injury (Emokpae et al,2010a). In certain diseases such as renal disease and sickle cell disease, the toxic material produced by activated phagocytes during reaction can cause maximal damage to the membrane because they are active in the lipid phase.…”

Section: Effect Of Oxidative Stressmentioning

confidence: 99%

Sickle Cell Disease and Renal Disease

Emokpae¹,

Uadia²

2012

Diseases of Renal Parenchyma

View full text Add to dashboard Cite

“…As manifestações clínicas comuns na DF, devem-se a dois fenômenos principais: a oclusão vascular pelos glóbulos vermelhos e a hemólise crônica, levando a lesão progressiva dos tecidos e órgãos (Emokpae et al, 2010;Braga, 2007).…”

Section: Introductionunclassified

Revisão das Propriedades Medicinais de Cajanus cajanna Doença Falciforme

Cordovil

Cople-Rodrigues

Santos

et al. 2015

Rev. bras. plantas med.

View full text Add to dashboard Cite

RESUMO:Este artigo descreve a ocorrência, características botânicas, fitoquímicas e a composição nutricional do feijão guandu [Cajanus cajan (L.) Millsp], e sua relação no processo de inibição da falcização na doença falciforme, um distúrbio genético que acomete as hemácias, gerando hemólise e anemia crônica. Dois constituintes químicos estariam mais relacionados aos efeitos inibitórios na falcização de células falciformes: L-fenilalanina e o ácido p-hidroxibenzóico. Estudos químico-biológicos detalhados com o feijão guandu no Brasil poderão esclarecer melhor os mecanismos pelos quais ocorre a inibição da falcização das hemácias e a diminuição do estresse oxidativo, ajudando no tratamento de pessoas com DF.Palavras-chave: propriedades medicinais, cajanus cajan, anemia falciforme. ABSTRACT: Review of Medicinal Cajanus cajan of properties in Sickle Cell Disease.This article describes the occurrence, botanical characteristics, phytochemical and nutritional composition of pigeonpea [Cajanus cajan (L.) Millsp], and their relationship in the process inhibition of sickling in sickle cell disease (SCD), a genetic disorder that affects red blood cells, causing hemolysis and chronic anemia. Two chemical components would be related to the inhibitory effect on sickling of sickle cells: the L-phenylalanine and the p-hydroxybenzoic acid. In Brazil, detailed studies with pigeonpea chemical-biological may clarify the mechanisms by which the inhibition of sickling of red blood cells occurs, reducing oxidative stress and thus helping treating people affected by this disease.

show abstract

Correlation of oxidative stress and inflammatory markers with the severity of sickle cell nephropathy

Abstract: Oxidative stress and inflammatory parameters correlate with sickle cell disease nephropathy.

Cited by 30 publications

References 21 publications

Association of Oxidative Stress Markers with Atherogenic Index of Plasma in Adult Sickle Cell Nephropathy

Association of Oxidative Stress Markers with Atherogenic Index of Plasma in Adult Sickle Cell Nephropathy

Sickle Cell Disease and Renal Disease

Revisão das Propriedades Medicinais de Cajanus cajanna Doença Falciforme

Contact Info

Product

Resources

About