Correlation of MicroRNA 17-92 Cluster Host Gene (MIR17HG) Polymorphisms With Susceptibility and Prognosis for Multiple Myeloma

Wu, Hongbo; Huang, Ting; Ye, Zhifeng; Fu, Xiaoqing; Hu, Keke; Yang, Xiurong

doi:10.1016/j.clml.2019.03.018

Cited by 14 publications

(24 citation statements)

References 23 publications

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“…In Multiple Myeloma (MM), MIR17HG rs7336610 T allele and MIR17HG rs4284505 G added the risk of MM, while rs7336610-rs4284505 "CA" haplotype decreased the risk of MM. While rs17735387 and rs1428 did not share any relationship with MM risk [15]. In colorectal cancer, rs7336610 and rs1428 were significantly related to increased risk of colorectal cancer.…”

Section: Discussionmentioning

confidence: 76%

“…Studies have confirmed that it participates in various growth and development processes such as cell proliferation and differentiation, angiogenesis, and plays an important role [10][11][12]. More and more studies have shown that the polymorphism of MIR17HG gene was associated with breast cancer [13], colorectal cancer [14], Multiple Myeloma [15].…”

Section: Introductionmentioning

confidence: 95%

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MIR17HG polymorphisms contribute to High altitude pulmonary edema susceptibility in Chinese Han people

Zhao

Long

et al. 2020

Preprint

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Background: High altitude pulmonary edema (HAPE) is a severe form of acute mountain sickness (AMS). The results of existing studies have shown that the onset of HAPE has obvious ethnic specificity and personal susceptibility, suggesting that the occurrence of HAPE is related to genetic factors. Therefore, six polymorphisms on MIR17HG were selected to investigate the effect of mutations on MIR17HG on HAPE in Chinese Han population.Materials and Methods: 487 healthy participants (244 participants had high altitude pulmonary edema, as the case group; and 243 participants had no symptoms of HAPE, as the control group) were genotyped via the Agena MassARRAY, and the relationship between polymorphisms on MIR17HG and HAPE risk was evaluated using a χ2 test with an odds ratio (OR) and 95% confidence intervals (CIs) in multiple genetic models.Results: In the allele model, we observed that lower risk (OR = 0.74, 95%CI: 0.56 - 0.98, p = 0.036) of the A allele for rs7318578 on the MIR17HG compared with the people with the C allele. Logistic regression analysis of four models for all selected MIR17HG SNPs between cases and controls showed significant differences for rs7318578 (OR = 0.74, 95%CI: 0.56 – 0.98, p = 0.037) and rs17735387 (OR = 1.51, 95%CI: 1.03 – 2.21, p = 0.036) in the HAPE population.Conclusion: rs7318578 and rs17735387 on MIR17HG were associated with the genetic susceptibility of HAPE in Chinese Han population.

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Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 95%

MIR17HG polymorphisms contribute to High altitude pulmonary edema susceptibility in Chinese Han people

Zhao

Long

et al. 2020

Preprint

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“…These results suggested that lncRNA MIR17HG could be of pathogenic importance in the development and prognosis of glioma. Several previous studies have reported the effect of MIR17HG genetic polymorphisms on the risk of various disease including tumors [24,25], but not in glioma.…”

Section: Discussionmentioning

confidence: 93%

Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population

Feng

Ouyang

et al. 2020

BMC Cancer

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Background lncRNA MIR17HG was upregulated in glioma, and participated in promoting proliferation, migration and invasion of glioma. However, the role of MIR17HG polymorphisms in the occurrence and prognosis of glioma is still unclear. Methods In the study, 592 glioma patients and 502 control subjects were recruited. Agena MassARRAY platform was used to detect the genotype of MIR17HG polymorphisms. Logistic regression analysis was used to evaluate the relationship between MIR17HG single nucleotide polymorphisms (SNPs) and glioma risk by odds ratio (OR) and 95% confidence intervals (CIs). Kaplan–Meier curves, Cox hazards models were performed for assessing the role of these SNPs in glioma prognosis by hazard ratios (HR) and 95% CIs. Results We found that rs7318578 (OR = 2.25, p = 3.18 × 10− 5) was significantly associated with glioma susceptibility in the overall participants. In the subgroup with age < 40 years, rs17735387 (OR = 1.53, p = 9.05 × 10− 3) and rs7336610 (OR = 1.35, p = 0.016) were related to the higher glioma susceptibility. More importantly, rs17735387 (HR = 0.82, log-rank p = 0.026) were associated with the longer survival of glioma patients. The GA genotype of rs17735387 had a better overall survival (HR = 0.75, log-rank p = 0.013) and progression free survival (HR = 0.73, log-rank p = 0.032) in patients with I-II glioma. We also found that rs72640334 was related to the poor prognosis (HR = 1.49, Log-rank p = 0.035) in female patients. In the subgroup of patients with age ≥ 40 years, rs17735387 was associated with a better prognosis (HR = 0.036, Log-rank p = 0.002). Conclusion Our study firstly reported that MIR17HG rs7318578 was a risk factor for glioma susceptibility and rs17735387 was associated with the longer survival of glioma among Chinese Han population, which might help to enhance the understanding of MIR17HG gene in gliomagenesis. In subsequent studies, we will continue to collect samples and follow up to further validate our findings and further explore the function of these MIR17HG SNPs in glioma in a larger sample size.

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“…It has been reported the rs7336610 and AC haplotype of rs4824505/rs7336610 are associated with risk of breast cancer [19]. Polymorphisms (rs7336610 and rs1428), haplotype AC (rs4284505-rs1428) and CA (rs7336610-rs4284505) of MIR17HG were correlated with increased multiple myeloma risk, whereas haplotype GC (rs4284505-rs1428) significantly elevated multiple myeloma risk [22]. Meanwhile, Kaplan-Meier curve analysis demonstrated that the CC genotype of rs7336610 and the AA genotype carriers of rs4284505 had higher 5-year survival.…”

Section: Discussionmentioning

confidence: 96%

“…It has been reported that the MIR17HG polymorphisms were associated with the risk of breast cancer [19], colorectal cancer [20,21] and multiple myeloma [22]. However, the association of the SNPs (rs75267932, rs72640334, rs7318578 and rs17735387) in MIR17HG with liver cancer susceptibility has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

MIR17HG polymorphism (rs7318578) is associated with liver cancer risk in the Chinese Han population

et al. 2020

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Numerous evidence has revealed that single-nucleotide polymorphisms (SNPs) are associated with liver cancer risk. To assess whether the MIR17HG polymorphisms are associated with the liver cancer risk in the Chinese Han population, we performed a case-control (432 liver cancer patients and 430 healthy controls) study. Genotyping of four variants of MIR17HG was performed with the Agena MassARRAY platform. We used χ2 test to compare the distribution of SNPs allele and genotypes frequencies of cases and controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression analysis to evaluate the association under genetic models. The results indicated that the rs7318578 was significantly associated with increased the risk of liver cancer in the allele (OR= 1.45, 95% CI: 1.18–1.77, P = 3.04E-04), recessive (OR = 3.69, 95% CI: 2.45–5.56, P = 4.52E-10) and additive model (OR = 1.35, 95% CI: 1.13–1.62, P = 0.001). Moreover, we found that individuals with the genotype CC of rs7318578 presented with an increased risk of liver cancer (OR = 3.03, 95% CI: 1.98–4.65, P = 3.83E-07); however, the CA genotype of rs7318578 significantly decreased the risk of liver cancer (OR = 0.61, 95% CI: 0.45–0.83, P = 0.001, compared with those with the AA genotype. Our findings indicated that MIR17HG polymorphism (rs7318578) contributes to liver cancer susceptibility to the Chinese Han population. Further studies with larger samples are required to confirm the results, as well as functional studies to determine the role of this SNP in miRNA expression or molecular pathways.

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Correlation of MicroRNA 17-92 Cluster Host Gene (MIR17HG) Polymorphisms With Susceptibility and Prognosis for Multiple Myeloma

Cited by 14 publications

References 23 publications

MIR17HG polymorphisms contribute to High altitude pulmonary edema susceptibility in Chinese Han people

MIR17HG polymorphisms contribute to High altitude pulmonary edema susceptibility in Chinese Han people

Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population

MIR17HG polymorphism (rs7318578) is associated with liver cancer risk in the Chinese Han population

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