Correlation of Microbiological and Histological Findings in Bovine Fibrinous Pneumonia

Schiefer, B.; Ward, G. E.; Moffatt, R E

doi:10.1177/030098587801500305

Cited by 37 publications

(24 citation statements)

References 3 publications

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“…The Pasteurella spp. (nine of 14) and H. somnus (10 of 11) were often associated with the severe fibrino-necrotizing type of bronchopneumonia, which is in accordance with former studies (Schiefer et al, 1978;Andrews et al, 1985;Bryson et al, 1990). Pasteurella multocida was frequently isolated in combination with other bacterial or viral pathogens which might indicate that this bacterium is usually not capable of inducing such severe lesions unless another pathogen acts concomitantly.…”

Section: Discussionsupporting

confidence: 90%

Pathological and Microbiological Studies on Pneumonic Lungs from Danish Calves

Tegtmeier

Uttenthal

Friis

et al. 1999

Journal of Veterinary Medicine, Series B

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During 1 year, the association between microbiological and pathological findings in 72 lungs from calves submitted to the Danish Veterinary Laboratory for diagnostic purposes was studied. All cases were evaluated pathologically and bacteriologically, whereas only 68 cases were examined for the presence of bovine respiratory syncytial virus (BRSV), parainfluenza-3 virus (PI-3 virus) and bovine coronavirus, 62 cases for bovine viral diarrhoea virus (BVD), 45 cases for bovine adenovirus and 51 cases for mycoplasmas. Based on histopathological examination, the cases were diagnosed as fibrinous and/or necrotizing bronchopneumonia, suppurative bronchopneumonia, embolic pneumonia and others. The diagnoses were based on the dominating and most severe lesions in each lung. Haemophilus somnus, Pasteurella multocida, Actinomyces pyogenes, P. haemolytica and BRSV were the most commonly found bacterial and viral lung pathogens, respectively. Pasteurella spp. and H. somnus were often associated with the more severe fibrinonecrotizing type of bronchopneumonia, whereas BRSV was primarily detected in cases of suppurative bronchopneumonia. Mycoplasma bovis was isolated from one case only, whereas M. dispar, M. bovirhinis and Ureaplasma diversum were present, often concomitantly, in the majority of cases. Aspergillus fumigatus was isolated from one case. U. S.

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Section: Discussionsupporting

confidence: 90%

Pathological and Microbiological Studies on Pneumonic Lungs from Danish Calves

Tegtmeier

Uttenthal

Friis

et al. 1999

Journal of Veterinary Medicine, Series B

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“…Occlusive thrombosis affects septal lymphatics. Florid and widespread necrotizing phlebitis, such as found in the Polymicrobial bronchopneumonia, in which H. somni is one component, is common, particularly after infection has been established for several weeks, and antibiotic treatments have been used (Schiefer et al 1978;Andrews et al 1985;Corbeil et al 1986;Gagea et al 2006;Booker et al 2008). Up to 60 % of cattle with pneumonia in which H. somni is detected at necropsy have one or more other respiratory pathogens (Booker et al 2008).…”

Section: Respiratory Disease In Cattlementioning

confidence: 99%

“…Such lungs have suppurative bronchopneumonia with bronchiectasis and bronchiolitis obliterans. Common coinfecting agents are Pasteurella multocida, Mannheimia haemolytica, Mycoplasma bovis, Trueperella pyogenes, and/or Bibersteinia trehalosi (Schiefer et al 1978;Panciera and Confer 2010). A common microscopic finding is the presence of multifocal necrosis, which can be confused with Pyogranulomatous caseonecrotic foci that typify chronic pneumonia due to Mycoplasma bovis (Caswell et al 2010).…”

Section: Respiratory Disease In Cattlementioning

confidence: 99%

Histophilosis as a Natural Disease

O’Toole

Sondgeroth

2015

Current Topics in Microbiology and Immunology

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Histophilus somni is responsible for sporadic disease worldwide in cattle and, to a lesser extent, in small ruminants, bighorn sheep (Ovis canadensis), and North American bison (Bison bison). The importance of H. somni diseases can be attributed to improved clinical and laboratory recognition, combined with the growth in intensive management practices for cattle. Although outbreaks of bovine histophilosis can occur year-round, in northern and southern hemispheres, it is most frequent in late fall and early winter. Weather, stress, dietary changes, and comingling of cattle are likely to be major triggers for outbreaks. The most frequent clinical expressions of histophilosis include undifferentiated fever, fibrinosuppurative pneumonia, encephalitis-leptomeningitis, necrotizing myocarditis, and diffuse pleuritis. Neurological disease occurs either as thrombotic meningoencephalitis (TME) or as suppurative meningitis with ventriculitis. Acute myocarditis is characteristically necrotizing and generally involves one or both papillary muscles in the left ventricular myocardium. Biofilm-like aggregates of bacteria occur in capillaries and veins in myocardium, in the central nervous system, and on endocardial surfaces. H. somni is a component of bovine respiratory disease (BRD) complex. In our experience, it is most commonly diagnosed in subacute-to-chronic polymicrobial pulmonary infections in combination with Mannheimia haemolytica, Trueperella pyogenes, Pasteurella multocida, or Mycoplasma bovis. Other, less common forms of H. somni disease present as polyarthritis/tenosynovitis, abortion with placentitis and fetal septicemia, epididymitis-orchitis, and ocular infections. It is likely that H. somni is under-recognized clinically and diagnostically. Most state and provincial laboratories in North America rely on bacterial isolation to confirm infection. The use of more sensitive detection methods on field cases of histophilosis will help resolve the pathogenesis of H. somni in natural outbreaks, and whether the disease is as common elsewhere as it is in Canada.

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“…In most survey studies of feedlot BRD, Mannheimia haemolytica has been the most commonly isolated species, followed closely by Pasteurella multocida, with fewer cases of Haemophilus somnus (Collier, 1969;Purdy et al, 1997;Scheifer et al, 1978). However, in some studies, P. multocida is the most common isolate (Allen et al, 1991;Singer et al, 1998), and many BRD investigators have become convinced that P. multocida is an important primary pathogen in BRD (Gourlay et al, 1989;Purdy et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Alteration of DNA adenine methylase (Dam) activity in Pasteurella multocida causes increased spontaneous mutation frequency and attenuation in mice

et al. 2003

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Pasteurella multocida is one of the primary bacterial pathogens associated with bovine respiratory disease (BRD) complex. Relatively few virulence factors of P. multocida have been characterized, and there is a need for improved vaccines for prevention of BRD. In other Gram-negative species, DNA adenine methylase (Dam) regulates the expression of virulence genes, and appropriate expression of Dam is required for virulence. In this study, the authors cloned and sequenced the P. multocida A1 dam gene and demonstrated that it is able to restore Dam function in an Escherichia coli dam mutant. When P. multocida dam was placed under the control of a constitutively expressed promoter on a plasmid, it caused an increased spontaneous mutation rate in P. multocida. In addition, the plasmid-mediated alteration of Dam production in P. multocida caused it to be highly attenuated in mice. These findings indicate that appropriate expression of Dam is required for virulence of P. multocida, which is believed to be the first report that Dam is required for virulence of a species in the Pasteurellaceae. Therefore, Dam may function as a virulence gene regulator in the Pasteurellaceae, similar to previously reported findings from other Gram-negative species.

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Correlation of Microbiological and Histological Findings in Bovine Fibrinous Pneumonia

Cited by 37 publications

References 3 publications

Pathological and Microbiological Studies on Pneumonic Lungs from Danish Calves

Pathological and Microbiological Studies on Pneumonic Lungs from Danish Calves

Histophilosis as a Natural Disease

Alteration of DNA adenine methylase (Dam) activity in Pasteurella multocida causes increased spontaneous mutation frequency and attenuation in mice

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