Correlation of microalbumin and sialic acid with anthropometric variables in type 2 diabetic patients with and without nephropathy

Abstract

Aim:The objective of this study is to correlate microalbumin and sialic acid levels with anthropometric variables in type 2 diabetic patients with and without nephropathy. Methods: This study was a case control study and included 108 Trinidadian subjects (aged 15-60 years) of which 30 were healthy individuals, 38 had type 2 diabetes, and 40 were of type 2 diabetic patients with nephropathy. Blood pressure and waist to hip ratio were recorded. Fasting venous blood samples and urine samples were collected from all the subjects. Blood samples were analysed for the glucose, C-reactive protein, and sialic acid. Urine sample was analysed for microalbumin and sialic acid. Results: Urinary microalbumin was higher among diabetic subjects (28.9 ± 30.3 mg/L) compared with controls (8.4 ± 10.2 mg/L) and was signifi cantly higher in diabetic patients with nephropathy (792.3 ± 803.9 mg/L). Serum sialic acid was higher in subjects with diabetic nephropathy (71.5 ± 23.3 mg/dL) compared to diabetics (66.0 ± 11.7 mg/dL) and controls (55.2 ± 8.3 mg/dL). Increased microalbumin and sialic acid were correlated with other cardiovascular risk factors such as hypertension and waist to hip ratios (p Ͻ 0.05). Conclusions: From these results it can be concluded that the increased microalbumin and sialic acid were strongly correlated with hypertension and waist to hip ratios in Trinidadian type-2 diabetic patients. Measurement of sialic acid, microalbumin, and waist to hip ratio along with the blood pressure is recommended for all type 2 diabetic patients to reduce the cardiovascular risk.

Association of serum sialic acid concentration with diabetic complications and cardiovascular risk factors in an Indian population

“…Besides this, serum SA levels have been reported to increase in type 1 DM patients with albuminuria [ 6 , 11 , 14 ]. We found higher SSA levels in diabetics with increased urinary microalbuminuria.…”

“…Nayak et al . even recommended measurement of SA, microalbumin, and waist-to-hip ratio along with the blood pressure for all type 2 diabetic patients, to assess the cardiovascular risk [ 14 ].…”

LC–MS/MS quantification of N-acetylneuraminic acid, N-glycolylneuraminic acid and ketodeoxynonulosonic acid levels in the urine and potential relationship with dietary sialic acid intake and disease in 3- to 5-year-old children

“…Urine is the most important excretory product containing Sia and an important marker for the clinical diagnosis of several inborn errors of Sia metabolism, including Salla disease, infant Sia storage disease and sialidosis ( 25 – 28 ) . Abnormal concentrations of urinary Sia have also been reported in adults and children with renal diseases ( 29 ) , diabetes ( 30 ) and cancer ( 31 ) . Given their potential importance, it is surprising that there is little information on the concentrations of urinary Sia such as Neu5Ac, Neu5Gc and KDN and the possible relationship of these concentrations with dietary Sia intake in pre-school children.…”

Correlations of sialic acid with glycated hemoglobin A1c and glycemia in postmenopausal women with type‑2 diabetes mellitus

“…In 2016, the World Health Organization (WHO) estimated that diabetes was the seventh leading cause of death worldwide. In addition, diabetes is associated with a significant decrease in the quality of life and significant morbidity due to severe complications (5)(6)(7). The frequency and severity of complications increase with the duration of the disease and patient age, and the most common complication is neuropathy followed by nephropathy and retinopathy (8,9).…”