Correlations of sialic acid with glycated hemoglobin A1c and glycemia in postmenopausal women with type‑2 diabetes mellitus

Olaru, Octavian Gabriel; Constantin, Gianina Ioana; Peña, Catalina

doi:10.3892/etm.2021.9717

Cited by 6 publications

(3 citation statements)

References 23 publications

(21 reference statements)

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“…The Hba1c% levels were determined by Bio Red Variant Analyzer whereas serum sialic acid levels were determined by Spectrophotometer using Ehrlich's reagent. 16 In order to compare the serum sialic acid levels between the two groups, we used SPSS version 22 and applied a student dependent t test to analyze the data.…”

Section: Methodsmentioning

confidence: 99%

Estimation of Serum Sialic Acid in the Patients of Type-2 Diabetes Mellitus

Chandio¹,

Shafi²,

Asif³

et al. 2022

PJMHS

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Background: Diabetes Mellitus is one of the leading cause of morbidity & mortality all over the world. The poor glycemic control in the patients of type-II diabetes mellitus can lead the development of complications which cause the morbidity in the life of diabetic population. The aim of this study was to estimate the serum sialic acid in the patients of type- II diabetes for early prediction of diabetic complications. Methodology: This case comparative study was conducted at the Diabetes Clinic of LUMHS Jamshoro with the collaboration of the Department of Biochemistry at LUMHS. A total of 84 diagnosed cases of type-II Diabetes Mellitus were included in this study. In group A, 40 diabetes mellitus cases were diagnosed with a history of diabetes less than five years, while in group B 44 had histories of diabetes over ten years. Spectrophotometers were used to measure serum sialic acid levels using Ehrlich's reagent. SPSS version 22 was used for data analysis with independent student t tests applied. Results: The mean serum sialic acid level of group A was 56.42 ± 5.67 mg/dl, while serum sialic acid level of group B was 69.88 ± 7.34 mg/dl. There was significant (p<0.05) increased level of serum sialic acid in the type-II diabetic patients of group B, which indicate there is more chance to development of micro vascular complications in type-II diabetic patients with prolong duration for their diseases period. Conclusion: Estimation of serum sialic acid in the patients of type-II diabetes mellitus is one of the early predictive marker for the complications of diabetes mellitus. Keywords: Type-II Diabetes Mellitus, Serum Sialic Acid, Estimation, HBA1C

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Section: Methodsmentioning

confidence: 99%

Estimation of Serum Sialic Acid in the Patients of Type-2 Diabetes Mellitus

Chandio¹,

Shafi²,

Asif³

et al. 2022

PJMHS

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“…Assessing blood glucose levels or other indicators of glycemic control such as glycosuria, glycated hemoglobin and glycated albumin (6) is therefore an essential tool in diabetes treatment.…”

Section: Continuous Glucose Monitoring Devices: a Brief Presentation (Review)mentioning

confidence: 99%

“…In order to minimize this burden, good glycemic control is crucial, since the diagnosis, is the key to prevent chronic complications. Assessing blood glucose levels or other indicators of glycemic control such as glycosuria, glycated hemoglobin and glycated albumin ( 6 ) is therefore an essential tool in diabetes treatment. In the mid-1800s, the first attempts to quantify glucose were made and glucose was measured in urine, using evaporation of urine to obtain sugar crystals.…”

Section: Introductionmentioning

confidence: 99%

Continuous glucose monitoring devices: A brief presentation (Review)

et al. 2021

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As diabetes prevalence is continuously increasing, better management is needed to achieve blood glucose control, in order to prevent complications and lessen the burden of this disease. Since the first measurement of glycosuria at the beginning of the 1900s', huge advances were made in monitoring glycemia. Continuous glucose monitoring systems revolutionized diabetes management, especially for patients with type 1 diabetes. Avoiding glycemic variability and maintaining optimal glycemic control is crucial for the evolution of patients with type 1 diabetes. The usefulness of glycemic monitoring devices can be extended to patients with type 2 diabetes. It is also important to note that in those patients at risk of developing high glycemic variability (e.g. patients with advanced chronic kidney disease), continuous glycemic monitoring may improve their prognosis. These monitoring systems can be classified according to the analytical method, the degree of invasiveness, the data availability and the mode of usage. The technology is constantly improving in bioanalytical performance, biocompatibility, length of wearing time, safety and clinical features. The aim of this review was to briefly present the main characteristics of glucose biosensors, glucose monitoring systems and their clinically utility.

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