Correlation of lung macrosections with pulmonary function in emphysema

Sweet, Herbert C.; Wyatt, John P.; Kinsella, Peter W.

doi:10.1016/0002-9343(60)90024-3

Cited by 30 publications

(3 citation statements)

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“…Numerous studies have attempted to identify physiological variables that could reliably detect and quantify emphysema, but the results of these studies have been disappointing [4][5][6][7][8][9][10][11]. However, the single measurement that most consistently relates to the severity of emphysema is the diffusing capacity for carbon monoxide (DLco) [4-8, 10, 12].…”

mentioning

confidence: 99%

Lung CT density correlates with measurements of airflow limitation and the diffusing capacity

Gould¹,

Redpath²,

Ryan³

et al. 1991

Eur Respir J

158

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We studied 80 subjects (63 M, 17 F; 23-82 yrs) and related lung computerized tomography (CT) density with age, height, spirometry, lung volumes, diffusing capacity and arterial blood gas tensions. These subjects demonstrated a wide range of physiological impairment (forced expiratory volume in one second (FEV1) 8-116% predicted; diffusing capacity (Kco) 15-139% predicted; arterial oxygen tension (Pao2) 38-91 mmHg). They ranged from normal subjects to patients with chronic respiratory failure. Lung density was derived from CT density histograms measured as both mean Emergency Medical Information (EMI) number (EMI scale: 0 = water, -500 = air, EMI number of normal lung tissue range approximately -200 to -450) and the lowest 5th percentile EMI number, the latter value being more likely to represent the density of lung parenchyma. Lung CT density correlated most strongly with airflow obstruction (EMI 5th percentile versus FEV1/forced vital capacity (FVC) % predicted, r = 0.73, p less than 0.001) and diffusing capacity (EMI 5th percentile versus Kco, r = 0.77, p less than 0.001). This suggests that reduction in lung density, which reflects loss of the surface area of the distal airspaces, is a major index of respiratory function in patients with smoking related chronic obstructive pulmonary disease (COPD). These data provide no indication of other factors such as small and large airways disease, and loss of elastic recoil, which may contribute to airflow limitation, or disruption of the pulmonary vascular bed which may also affect CT lung density.

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mentioning

confidence: 99%

Lung CT density correlates with measurements of airflow limitation and the diffusing capacity

Gould¹,

Redpath²,

Ryan³

et al. 1991

Eur Respir J

158

View full text Add to dashboard Cite

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“…T h u s, W yatt [17] h as u sed a grid s y ste m w ith e stim a tio n o f e x te n t of e m p h y se m a w ith in selected a re a s. Mitchell [18] used an o v erall e s tim a te o f th e e x te n t o f d am ag e. Cromie [8] u sed a m ore e la b o ra te m e th o d in w h ic h th e a p p e a ra n c e o f tissu e w ith in each sq u are o f a grid w as c o m p a re d w ith a g ra d e d series o f p h o to g ra p h s of in creasin g ly sev ere e m p h y se m a . E a c h sq u a re o f th e g rid w as given a n u m b e r c o rre sp o n d in g to th e g ra d e , a n d th e e x te n t o f em p h y se m a w as c a l c u la te d as th e a v e ra g e o f th e se n u m b e rs.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Relationship between Structural Extent of Centrilobular Emphysema and Postmortem Volume and Flow Characteristics of Lungs

Pratt¹,

Jutabha²,

Klugh³

1965

Respiration

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“…Since 1960 LS have been proven to be useful to study the extension and distribution of lung diseases as emphysema [36] and, more recently the size of the tumours, to plan radiotherapy in cases of nonsmall lung cancer [37]. In current practice, LS are useful in staging cases of lung cancer (Figure 4) as the relationship between the tumour mass and the adjacent obstructive pneumonia is difficult to establish at macroscopic level (Figure 5).…”

Section: Large Section In Anatomic and Surgical Pathologymentioning

confidence: 99%

The Value of Large Sections in Surgical Pathology

Foschini

Baldovini

Ishikawa

et al. 2012

International Journal of Breast Cancer

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Large format sections (LS) first have been introduced in breast pathology more than a century ago. Since then, they constituted for longtime a research tool to better understand breast microanatomy and the relationship between radiological images and pathological features. Similarly LS have been used to study neoplastic, inflammatory, and degenerative diseases affecting various organs, as brain, lung, gastrointentinal tract, bone, urinary tract, prostate, and placenta. Currently LS are mostly applied to diagnostic routine to better stage tumours such as prostate and breast carcinomas or to correlate radiologic imaging to gross specimens. The purpose of the present paper is to review the historical background and the basis of the applications of LS in surgical pathology, with special emphasis on breast tumours.

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Correlation of lung macrosections with pulmonary function in emphysema

Cited by 30 publications

References 1 publication

Lung CT density correlates with measurements of airflow limitation and the diffusing capacity

Lung CT density correlates with measurements of airflow limitation and the diffusing capacity

Quantitative Relationship between Structural Extent of Centrilobular Emphysema and Postmortem Volume and Flow Characteristics of Lungs

The Value of Large Sections in Surgical Pathology

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