Correlation of Ischemic Area and Coronary Flow With Ameroid Size in a Porcine Model

Tüzün, Egemen; Oliveira, Eddie; Narin, Cüneyt; Khalil, Hassan A.; Jimenez-Quevedo, Pilar; Perin, Emerson C.; Silva, Guilherme

doi:10.1016/j.jss.2009.03.024

Cited by 12 publications

(15 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[2][3][4][30][31][32] Differentiation between viable nonreversible and viable reversible (hibernating) myocardium is also possible because the presence of viable myocardium does not necessarily imply a recovery of function after revascularization. 33,[39][40][41][42] Brief repetitive ischemia, such as that caused by percutaneous coronary intervention (PCI), leading to temporary decrease in local wall motion (called 'stunning') can also be identified on the basis of mismatch between the voltage and LLS maps.…”

Section: Assessment Of Myocardial Viabilitymentioning

confidence: 99%

“…[21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] The exploitation of the simultaneous recording of quantified viability and mechanical function of the infarcted area and the spatial display of the infarct border zone have led to the development of approaches for electro mechanical guidance of percutaneous intra myocardial therapies.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic and prognostic value of 3D NOGA mapping in ischemic heart disease

Gyöngyösi

Dib

2011

Nat Rev Cardiol

View full text Add to dashboard Cite

The three-dimensional NOGA(®) (Biologics Delivery Systems, a Johnson & Johnson company, Irwindale, CA, USA) electromechanical mapping system simultaneously registers the electrical and mechanical activities of the left ventricle, enabling online assessment of myocardial viability. The system distinguishes between viable, nonviable, stunned, and hibernating myocardium and can assess wall motion. The evaluation of the electrophysiological state of the tissue by NOGA(®) mapping has been validated by comparing the electroanatomical voltage and local linear shortening maps obtained with this technique with several noninvasive diagnostic tests. Bipolar signal analysis and determination of the existence and degree of transmural infarctions are also possible with NOGA(®). Immediately after percutaneous coronary intervention, an increased electromechanical discordance between voltage and local linear shortening maps indicates procedure-induced stunning that is caused by repetitive ischemia or microvascular compromise. Catheter-based direct intramyocardial injection of cells or gene constructs by NOGA(®) reduces the likelihood of systemic toxicity of the injected substance, resulting in minimal washout, limited exposure of nontarget organs, and precise localization to ischemic and peri-ischemic myocardial regions in patients with chronic myocardial ischemia. In addition, direct intramyocardial injection enables the treatment of chronic myocardial infarction by provoking a chemotactic signal at the injection-injury site that contributes to cell engraftment. By measuring the electrical activation pattern in delayed-motion areas, NOGA(®) might also be useful to predict response to cardiac resynchronization therapy.

show abstract

Section: Assessment Of Myocardial Viabilitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diagnostic and prognostic value of 3D NOGA mapping in ischemic heart disease

Gyöngyösi

Dib

2011

Nat Rev Cardiol

View full text Add to dashboard Cite

show abstract

“…CVBG surgery is indicated for both the relief of symptoms and the improvement of life expectancy in patients suffering from diffuse coronary heart disease [39][40][41]. We believe the selective CVBG should be considered in cases of coronary artery disease not amenable to traditional revascularization strategies [42][43][44][45].…”

Section: Resultsmentioning

confidence: 99%

Surgical Treatment for Diffuse Coronary Artery Diseases

Gu-Cheng¹,

Yu²,

Wang³

2013

Artery Bypass

View full text Add to dashboard Cite

“…Ameroid-induced progressive coronary occlusion was performed as described previously (30). Briefly, initial sedation was achieved with intramuscularly ketamine hydrochloride (20 mg/kg), diazepam (0.05 mg/kg) and atropine (0.05 mg/kg).…”

Section: Animal Experiments and Gene Deliverymentioning

confidence: 99%

Attenuation of Endoplasmic Reticulum Stress-Related Myocardial Apoptosis by SERCA2a Gene Delivery in Ischemic Heart Disease

Wei

et al. 2010

Mol Med

View full text Add to dashboard Cite

Previous studies suggested that endoplasmic reticulum (ER) stress-associated apoptosis plays an important role in the pathogenesis of ischemic heart disease. Gene transfer of sarco/endoplasmic reticulum Ca 2+ ATPase 2a (SERCA2a) attenuates myocardial apoptosis in a variety of heart failure models. This study is to investigate the effects of SERCA2a gene delivery on the myocardial apoptosis and ER stress pathway in a porcine ischemic heart disease model. Eighteen pigs were either subjected to ameroid implantation in the coronary artery or sham operation. Eight wks after gene delivery, the protein level and activity of SERCA2a were measured. Myocardial apoptosis was determined using terminal deoxynucleotidyl transferase-mediated DNA nick-end labeling assay. Regional myocardial perfusion and function were evaluated by 99m Tc-sestamibi ( 99m Tc-MIBI) single photon emission computed tomography and echocardiography. The ER stress signaling was assessed by Western blot. SERCA2a protein level and activity were significantly decreased in the ischemic myocardium and restored to normal after SERCA2a gene transfer. Restoration of SERCA2a expression significantly improved the cardiac function, although no improvement of regional myocardial perfusion was detected. Restoration of SERCA2a significantly attenuated myocardial apoptosis and reversed the activation of unfolded protein response (UPR) pathway and the ER stress-associated apoptosis pathways. These findings demonstrate a robust role of SERCA2a in attenuation of ischemic myocardial apoptosis, correlating with reverse activation of the ER stress-associated apoptosis pathways, suggesting that the beneficial effects of SERCA2a gene transfer may involve the attenuation of ER stress-associated myocardial apoptosis.

show abstract

Correlation of Ischemic Area and Coronary Flow With Ameroid Size in a Porcine Model

Cited by 12 publications

References 16 publications

Diagnostic and prognostic value of 3D NOGA mapping in ischemic heart disease

Diagnostic and prognostic value of 3D NOGA mapping in ischemic heart disease

Surgical Treatment for Diffuse Coronary Artery Diseases

Attenuation of Endoplasmic Reticulum Stress-Related Myocardial Apoptosis by SERCA2a Gene Delivery in Ischemic Heart Disease

Contact Info

Product

Resources

About