Correlation of inflammatory cytokines with arthroscopic findings in patients with temporomandibular joint internal derangements

Sandler, Noah A.; Buckley, Michael; Cillo, Joseph E.; Bräun, Thomas

doi:10.1016/s0278-2391(98)90446-3

Cited by 130 publications

(56 citation statements)

References 46 publications

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“…6 Further studies showed that IL-6 is one of the most important pro-inflammatory cytokines that contribute to the pathogenesis of internal derangement in the TMJ. [6][7][8] Sato et al 9 detected the substance in nearly 50% of the synovial tissue specimen taken from TMJs with internal derangement. Other chemical mediators like a new peptide such as substance p and serotonin have also been detected in the TMJs and are thought to contribute to internal derangement.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of oral and parafunctional habits in Nigerian patients suffering temporomandibular joint pain and dysfunction

Saheeb¹

2009

Journal of Medicine and Biomedical Research

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Pain and dysfunction of the temporo-mandibular joint (TMJ) still pose a therapeutic dilemma to the oral and maxillofacial surgeon. Epidemiological data on the disorder in Nigerians appear not to be available, as only few studies are recorded.1 Studies from North America revealed a prevalence rate of 12.1% amongst adults, 2 although some authors have claimed that pain, clicking and locking have been experienced by approximately 20% of the general population. Pain in the joint and muscles is often distressing to patients. Advances in research in this area have thrown more light on the probable causes of the pain. The concept of inflammatory changes in the joint synovium, capsule or retrodiscal tissues as the principal underlying cause of pain has been documented. 4 Large quantities of inflammatory mediators of pain were identified in the synovial fluid of Prevalence of oral and parafunctional habits in Nigerian patients suffering temporomandibular joint pain and dysfunction BDO Saheeb ABSTRACTThis study was conducted to determine the prevalence of oral and parafunctional habits in Nigerian patients suffering temporomandibular joint pain and dysfunction. It consisted of patients that were referred for treatment at the oral and maxillofacial surgery clinic of the University of Benin Teaching Hospital, Benin City, Nigeria. A pre-designed data form was used to collect information on age, gender, reasons for attendance, joint pain, side of pain, clicking, oral habits known to patient, parafunctional habits, occlusion and dietary habits. A total of 29 patients comprising 48.3% male and 51.7% female in a male to female ratio of 1:1.1 were studied. Their age ranged from 17 to 70 years. Eighty two per cent of them complained of joint pain on presentation while 17.1% complained of muscle pain. The joint pain was mainly unilateral in 62.1% and bilateral in 20.7%. Twenty six (89.7%) patients indulged in oral and parafunctional habits such as unilateral mastication 65.5%, hand-on-chin posture 58.6%, clenching 17.2%, tooth grinding 13.8%, chewing gum 37.9%, and finger and nail biting 24.1%. In all, 31.0% of males and 34.5% of females had clicking joints. Reciprocal click was detected in 52.6% of the study sample. There was a prevalence of 89.7% of oral and parafunctional habits in Nigerian patients suffering temporomandibular joint pain and dysfunction.

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Section: Introductionmentioning

confidence: 99%

Prevalence of oral and parafunctional habits in Nigerian patients suffering temporomandibular joint pain and dysfunction

Saheeb¹

2009

Journal of Medicine and Biomedical Research

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“…This hypothesis is supported by data from several investigations [Shafer et al, 1994;Fu et al, 1995;Kubota et al, Control Inflammation and Bony Changes at the TMJ Cells Tissues Organs 2001;169:257-264 259 1997, 1998Alstergren et al, 1998;Kopp, 1998;Sandler et al, 1998;Takahashi et al, 1998;Fang et al, 1999].…”

Section: Introductionmentioning

confidence: 70%

“…Here again, levels of IL-6 were elevated in TMD patients. Both limited range of motion [Takahashi et al, 1998] and bony changes/osteoarthritis [Kubota et al, 1997[Kubota et al, , 1998Sandler et al, 1998] were found to correlate with higher levels of IL-6.…”

Section: Resultsmentioning

confidence: 99%

“…Such observations have led many researchers to believe that knowledge of osteoarthritis (OA), RA, and the associated inflammation of the synovial joints could be applied to the TMJ. Multiple cytokines have been identified in the synovial fluid of patients with temporomandibular disorders (TMD) that resemble those involved in OA and RA in other synovial joints [Holmlund et al, 1991;Shafer et al, 1994;Fu et al, 1995;Kubota et al, 1997Kubota et al, , 1998Alstergren et al, 1998;Kopp, 1998;Sandler et al, 1998;Takahashi et al, 1998;Fang et al, 1999]. It is thought that these cytokines are involved in bony changes, such as osteophyte formation and erosion (resorption), at the TMJ [Takahashi et al, 1998].…”

Section: Introductionmentioning

confidence: 99%

“…Studies evidencing the role of cytokines in the TMJ have primarily focused on tumor necrosis factor-· (TNF·), interleukin-1ß (IL-1ß), IL-6, IL-8, interferon-Á (IFN-Á), interleukin-1 receptor antagonist (IL-1ra), and IL-10 [Shafer et al, 1994;Fu et al, 1995;Kubota et al, 1997Kubota et al, , 1998Alstergren et al, 1998;Kopp, 1998;Sandler et al, 1998;Takahashi et al, 1998;Fang et al, 1999].…”

Section: Introductionmentioning

confidence: 99%

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Inflammation and Bony Changes at the Temporomandibular Joint

Kacena

Merrel

Konda

et al. 2001

Cells Tissues Organs

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Cytokines help mediate the acute and chronic inflammation and associated destruction of connective tissue in arthritic temporomandibular joints (TMJ). The proinflammatory cytokines TNFα, IL-1β, IL-6, IL-8, and IFN-γ are associated with inflammation in synovial joints and connective tissue destruction. Therefore, the increased levels of these cytokines in the synovial fluid of temporomandibular disorder (TMD) patients would be expected. Conversely, IL-1ra and IL-10 acts as inhibitors to these proinflammatory cytokines. Thus, in TMD patients, low levels of IL-1ra and IL-10 might be expected. A review of studies from multiple investigators confirms that proinflammatory cytokine levels increase in TMD patients, IL-1ra levels are also increased, and IL-10 levels remain unchanged. Because IL-10 can inhibit TNFα, IL-1, IL-6, and IL-8, the lack of IL-10 in the TMJ in the face of the other studies showing increases in TNFα, IL-1β, IL-6, and IL-8 could partially explain the exacerbation of the associated osteoarthritis. In addition, although IL-1ra levels are elevated in most of the TMD patients, the increases do not appear to be sufficient to inhibit the inflammation and connective tissue degradation associated with IL-1β. Thus, it appears that treatment of TMD requires a delicate balance between proinflammatory cytokines and cytokine inhibitors such as IL-1ra and IL-10.

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Cytokines (Tumor Necrosis Factor, Interleukins) and Prostaglandins

Alstergren

2009

Peripheral Receptor Targets for Analgesia

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Correlation of inflammatory cytokines with arthroscopic findings in patients with temporomandibular joint internal derangements

Cited by 130 publications

References 46 publications

Prevalence of oral and parafunctional habits in Nigerian patients suffering temporomandibular joint pain and dysfunction

Prevalence of oral and parafunctional habits in Nigerian patients suffering temporomandibular joint pain and dysfunction

Inflammation and Bony Changes at the Temporomandibular Joint

Cytokines (Tumor Necrosis Factor, Interleukins) and Prostaglandins

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