Correlation of IL-6 with the classical humoral disease activity parameters ESR and CRP and with serum cortisol, reflecting the activity of the HPA axis in active rheumatoid arthritis

Boss, B.; Neeck, Gunther

doi:10.1007/s003930070020

Cited by 36 publications

(19 citation statements)

References 15 publications

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“…Analysis of basal cortisol in RA patients and controls showed similar results, in agreement with several studies that addressed the HPA axis in rheumatoid arthritis and showed cortisol concentrations similar to or higher than in the control group (Crofford et al, 1997;Boss and Neeck, 2000).…”

Section: Discussionsupporting

confidence: 89%

Quantitation of glucocorticoid receptor alpha and NF-κB pathway mRNA and its correlation with disease activity in rheumatoid arthritis patients

Cavalcante

Melo²,

Dinis³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. We measured NF-κB, IKK, c-Fos, and GRα mRNA expression and in vivo glucocorticoid sensitivity in patients with rheumatoid arthritis. A very low dose intravenous dexamethasone suppression test and real-time PCR quantitation of mRNA of these genes were performed on blood samples from 21 rheumatoid arthritis patients who were not on glucocorticoids during the previous four months and on blood samples from 20 healthy individuals. Mean rheumatoid arthritis duration was 8.8 years, and mean disease activity, as assessed by Disease Activity Score 28 (DAS28), was 4.45. Basal cortisol and the percentage of cortisol reduction after the very low dose intravenous dexamethasone suppression test, as well as NF-κB, IKK, c-Fos, and GRα mRNA expression, were similar among groups. We did not observe significant correlations between glucocorticoid in vivo sensitivity and DAS28. There was a positive correlation between 2301 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 9 (4): 2300-2310 (2010) Gene expression in rheumatoid arthritis DAS28 and NF-κB, IKK, and GRα, but not c-Fos. In the multivariate analysis, only NF-κB mRNA remained as an independent variable for predicting DAS28.

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Section: Discussionsupporting

confidence: 89%

Quantitation of glucocorticoid receptor alpha and NF-κB pathway mRNA and its correlation with disease activity in rheumatoid arthritis patients

Cavalcante

Melo²,

Dinis³

et al. 2010

Genet. Mol. Res.

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“…The observed significant positive correlation between these two indicators of inflammation with a correlation coefficient r ) 0.6434 and a p-value < 0.0001 is in agreement with previous reports. 20,21 Interestingly, the degree of joint destruction in our patient cohort expressed as RA stage is inversely related to the patient age (r ) -0.4677, p ) 0.0069), that is, younger patients exhibit a greater degree of joint destruction. Because of the difficulty in interpretation of a relationship between patient age at the time point of blood donation and joint functionality, we calculated the age at which RA was diagnosed for the first time in that patient, which is a more meaningful parameter in description of RA patients.…”

Section: Resultsmentioning

confidence: 93%

Proteomic Analysis of Peripheral Blood Mononuclear Cells: Selective Protein Processing Observed in Patients with Rheumatoid Arthritis

et al. 2007

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In a comparative proteome analysis of peripheral blood mononuclear cells (PBMCs), we analyzed 130 two-dimensional gels obtained from 33 healthy control individuals and 32 patients diagnosed with rheumatoid arthritis (RA). We found 16 protein spots that are deregulated in patients with RA and, using peptide mass fingerprinting and Western blot analyses, identified these spots as belonging to 9 distinct proteins. A hierarchical clustering procedure organizes the study subjects into two main clusters based on the expression of these 16 protein spots, one that contains mostly healthy control individuals and the other mostly RA patients. The majority of the proteins differentially expressed in RA patients when compared with healthy controls can be detected as protein fragments in PBMCs obtained from RA patients. This set of deregulated proteins includes several factors that have been shown to be autoantigens in autoimmune diseases.

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“…The well-known fact that many markers of bacterial infection like increased leukocyte count, serum CRP level, and ESR can also be present in inflammatory diseases, such as rheumatoid arthritis and Still's disease (Boss and Neeck, 2000;Cunha et al, 2006;Kotter et al, 2007) raises the question whether differentiation between bacterial infection and an acute flare of inflammatory disease could be improved using BIS test. Unfortunately, because the group of patients with an underlying inflammatory disease in this study was too small and heterogeneous for a meaningful analysis, this question remains without a satisfactory answer.…”

Section: Discussionmentioning

confidence: 99%

A rapid flow cytometric method for distinguishing between febrile bacterial and viral infections

Nuutila

Jalava-Karvinen

Hohenthal

et al. 2013

Journal of Microbiological Methods

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Correlation of IL-6 with the classical humoral disease activity parameters ESR and CRP and with serum cortisol, reflecting the activity of the HPA axis in active rheumatoid arthritis

Cited by 36 publications

References 15 publications

Quantitation of glucocorticoid receptor alpha and NF-κB pathway mRNA and its correlation with disease activity in rheumatoid arthritis patients

Quantitation of glucocorticoid receptor alpha and NF-κB pathway mRNA and its correlation with disease activity in rheumatoid arthritis patients

Proteomic Analysis of Peripheral Blood Mononuclear Cells: Selective Protein Processing Observed in Patients with Rheumatoid Arthritis

A rapid flow cytometric method for distinguishing between febrile bacterial and viral infections

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