Correlation of house dust mite–specific lymphocyte proliferation with IL-5 production, eosinophilia, and the severity of symptoms in infants with atopic dermatitis

Kimura, Mitsuaki; Tsuruta, Satoru; Yoshida, Takami

doi:10.1016/s0091-6749(98)70197-6

Cited by 75 publications

(63 citation statements)

References 21 publications

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“…Clinical studies have provided evidence that a house dust mite allergen plays a causative or exacerbating role in human AD 36 and that a strong correlation exists between patients with FLG null alleles and house dust mitespecific IgE. 37 AD-like skin lesions can be induced by repeated topical application of a mite allergen in NC/Nga mice but not in BALB/c mice.…”

Section: Discussionmentioning

confidence: 99%

Flaky Tail Mouse Denotes Human Atopic Dermatitis in the Steady State and by Topical Application with Dermatophagoides pteronyssinus Extract

Moniaga

Egawa

Kawasaki

et al. 2010

The American Journal of Pathology

120

126

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Section: Discussionmentioning

confidence: 99%

Flaky Tail Mouse Denotes Human Atopic Dermatitis in the Steady State and by Topical Application with Dermatophagoides pteronyssinus Extract

Moniaga

Egawa

Kawasaki

et al. 2010

The American Journal of Pathology

120

126

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“…IL-4 and IL-13 are implicated in the initial phase of tissue inflammation and may mediate an isotype switching to IgE synthesis, and upregulation expression of adhesion molecules on endothelial cells 40 . IL-5 increases the survival of eosinophils and a systemic eosinophilia with an increase of the ECP correlate to disease severity 41,42 .…”

Section: (2) Acquired Immunity ① T Cells and The Th1/th2 Conceptmentioning

confidence: 99%

Atopic Dermatitis

2010

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“…Cell cultures were performed according to a previously described method with some modifications [2]. Heparinized peripheral blood was obtained from subjects at routine blood examination.…”

Section: Methodsmentioning

confidence: 99%

“…We showed that house dust mite (HDM) also makes a significant contribution to the development of AD in infants by inducing IL-5 production, a proinflammatory Th2 cytokine, by HDM-specific Th2 cells [2]. However, it still remains unclear whether pollens influence the clinical course of AD in infants.…”

Section: Introductionmentioning

confidence: 99%

Japanese Cedar-Pollen-Specific IL-5 Production in Infants with Atopic Dermatitis

Kimura

Obi²,

Saito³

2004

Int Arch Allergy Immunol

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Background: Although food allergens and house dust mites are thought to contribute to the development of atopic dermatitis (AD) in infants, the influence of pollens has not yet been well defined. Objective: This study attempted to clarify the effect of Japanese cedar pollens (JCPs), which are scattered in Japan between February and April, on AD in infants. Methods: In the first study, seasonal changes in the number of patients who first visited our institute due to AD were analyzed by reviewing medical records of 184 infants with AD. In the second study, peripheral blood mononuclear cells from 81 children (50 infants <1 year and 31 older children) with AD were stimulated with a standardized JCP allergen. The production of IL-5 was measured and its correlation with the severity of AD in infants was analyzed. Results: The number of infants who first visited the institute due to AD peaked in spring. JCP-specific IL-5 production began to increase immediately after the first contact with JCPs in infants with AD. The production of IL-5 in infants with AD exposed to JCPs was significantly higher than in control subjects (p < 0.002) or in AD infants never exposed to JCPs (p < 0.02). There was a significant positive correlation between IL-5 production and the severity of AD in infants (p < 0.0001). Conclusion: These results suggest that JCPs play an important role in the aggravation of infantile AD in spring by inducing IL-5 production.

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Correlation of house dust mite–specific lymphocyte proliferation with IL-5 production, eosinophilia, and the severity of symptoms in infants with atopic dermatitis

Cited by 75 publications

References 21 publications

Flaky Tail Mouse Denotes Human Atopic Dermatitis in the Steady State and by Topical Application with Dermatophagoides pteronyssinus Extract

Flaky Tail Mouse Denotes Human Atopic Dermatitis in the Steady State and by Topical Application with Dermatophagoides pteronyssinus Extract

Atopic Dermatitis

Japanese Cedar-Pollen-Specific IL-5 Production in Infants with Atopic Dermatitis

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