Atopic Dermatitis

Bieber, Thomas

doi:10.5021/ad.2010.22.2.125

Cited by 631 publications

(809 citation statements)

References 101 publications

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“…The term “atopic disease” often is used to group clinically diverse hypersensitivity syndromes and symptoms. It is defined as an inherited predisposition to allergic disease via IgE‐mediated pathophysiology 11. Investigation of serum IgE in equine MHS would also be interesting, but was not possible in this study.…”

Section: Discussionmentioning

confidence: 98%

“…Furthermore, the combined occurrence of allergic dermatitis, conjunctivitis, rhinitis, and asthma‐like clinical signs has been reported both in naturally occurring and experimental hypersensitivities in dogs 8. The occurrence of MHS, such as asthma, rhinitis, and allergic skin diseases, in the same individual also has been described in humans 9, 10, 11, 12. A temporal sequence of hypersensitivities has been termed an “allergic march” with childhood atopic dermatitis being the precursor to allergic rhinitis and asthma years later 12…”

mentioning

confidence: 96%

“…For instance, interleukin‐4 receptor α‐chain ( IL4RA ) has been identified as a candidate gene in atopic dermatitis, rhinitis, and asthma. In addition, IL4RA has been linked to an “allergic predisposition” and is associated with increased serum immunoglobulin E (IgE) concentrations in asthma‐affected humans 9, 10, 11. Polymorphisms in IL13 , a gene involved in the same T‐helper‐2 (Th2)‐type response as IL4RA , are associated with both rhinitis and asthma, and rhinitis was shown to be a risk factor for the development of asthma 10.…”

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confidence: 99%

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Multiple Hypersensitivities Including Recurrent Airway Obstruction, Insect Bite Hypersensitivity, and Urticaria in 2 Warmblood Horse Populations

Kehrli

Jandova

Fey

et al. 2014

Veterinary Internal Medicne

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BackgroundMultiple hypersensitivities (MHS) have been described in humans, cats, and dogs, but not horses.HypothesesHorses suffering from recurrent airway obstruction (RAO), insect bite hypersensitivity (IBH), or urticaria (URT) will have an increased risk of also being affected by another one of these hypersensitivities. This predisposition for MHS also will be associated with decreased shedding of strongylid eggs in feces and with a single nucleotide polymorphism (SNP BIEC2‐224511), previously shown to be associated with RAO.AnimalsThe first population (P1) included 119 randomly sampled horses representative of the Swiss sporthorse population; the replication population (P2) included 210 RAO‐affected Warmblood horses and 264 RAO‐unaffected controls. All horses were Warmbloods, 14 years or older.MethodsAssociations between disease phenotypes (RAO, IBH, URT, MHS) fecal egg counts, the SNP BIEC2‐224511 as well as management and environmental factors were investigated.ResultsIn P1, RAO‐affected horses had a 13.1 times higher odds ratio (OR) of also suffering from IBH (P = .004). In P2, the respective OR was 7.4 (P = .002) and IBH‐affected horses also showed a 7.1 times increased OR of concomitantly suffering from URT (P < .001). IBH, URT, and MHS phenotypes were significantly associated with the absence of nematode eggs in the feces.Conclusions and Clinical ImportanceThis is the first report of MHS in horses. Specifically, an increased risk for IBH should be expected in RAO‐affected horses.

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 96%

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confidence: 99%

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Multiple Hypersensitivities Including Recurrent Airway Obstruction, Insect Bite Hypersensitivity, and Urticaria in 2 Warmblood Horse Populations

Kehrli

Jandova

Fey

et al. 2014

Veterinary Internal Medicne

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“…(1) Despite the power of molecular approaches and persistent investigative efforts, AD remains an enigmatic disorder and the agent (or agents) triggering this skin disorder remains to be completely identified. AD is thought to be associated with the dysfunctioning of skin barrier and Th2 cell adaptive immune responses to common environmental allergens.…”

Section: Introductionmentioning

confidence: 99%

Molecular Genetic of Atopic Dermatitis : An Update

Al‐Shobaili

Ahmed

Alnomair

et al. 2016

IJHS

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Atopic dermatitis (AD) is a chronic multifactorial inflammatory skin disease. The pathogenesis of AD remains unclear, but the disease results from dysfunctions of skin barrier and immune response, where both genetic and environmental factors play a key role. Recent studies demonstrate the substantial evidences that show a strong genetic association with AD. As for example, AD patients have a positive family history and have a concordance rate in twins. Moreover, several candidate genes have now been suspected that play a central role in the genetic background of AD. In last decade advanced procedures similar to genome-wide association (GWA) and single nucleotide polymorphism (SNP) have been applied on different population and now it has been clarified that AD is significantly associated with genes of innate/adaptive immune systems, human leukocyte antigens (HLA), cytokines, chemokines, drug-metabolizing genes or various other genes. In this review, we will highlight the recent advancements in the molecular genetics of AD, especially on possible functional relevance of genetic variants discovered to date.

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“…The lifetime prevalence of AD is estimated between 15-30% in children and 2-10% in adults (1,2). AD is characterized by intense itching and follows a relapsing and remitting course (3).…”

Section: Introductionmentioning

confidence: 99%

Predicting therapy response to mycophenolic acid using UGT1A9 genotyping: towards personalized medicine in atopic dermatitis

Thijs¹,

Geest²,

Schaft³

et al. 2016

Journal of Dermatological Treatment

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Atopic dermatitis (AD) is a very common chronic inflammatory skin disease requiring long-term treatment. Mycophenolic acid (MPA) is used off-label in treatment of patients with severe AD failing Cyclosporin A (CsA) treatment, however clinical efficacy is observed in only half of the AD patients. In blood, MPA levels are known to have a large interindividual variability. Low MPA exposure and increased enzyme activity correlates with the presence of UGT1A9 polymorphisms. In this retrospective study, 65 adult AD patients treated with MPA were classified as responder or non-responder to MPA treatment. UGT1A9 polymorphisms were determined using PCR. A significantly higher number of UGT1A9 polymorphisms was found in the group that did not respond to MPA treatment. Of the patients that carried a UGT1A9 polymorphism, 85.7% were non-responsive to MPA treatment. This implies that non-responsiveness in AD patients is more likely to occur in carriers of a UGT1A9 polymorphism. In a binary logistic regression analysis the odds ratio (OR) was 8.65 (95% confidence interval: 0.93-80.17). Our results show that UGT1A9 polymorphisms can be used to identify patients with non-responsiveness to MPA. Patients with UGT1A9 polymorphisms might benefit from higher MPA dosage. ARTICLE HISTORY

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Atopic Dermatitis

Cited by 631 publications

References 101 publications

Multiple Hypersensitivities Including Recurrent Airway Obstruction, Insect Bite Hypersensitivity, and Urticaria in 2 Warmblood Horse Populations

Multiple Hypersensitivities Including Recurrent Airway Obstruction, Insect Bite Hypersensitivity, and Urticaria in 2 Warmblood Horse Populations

Molecular Genetic of Atopic Dermatitis : An Update

Predicting therapy response to mycophenolic acid using UGT1A9 genotyping: towards personalized medicine in atopic dermatitis

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