Correlation of high-sensitivity C-reactive protein and carotid plaques with coronary artery disease in elderly patients

Yue, Liang; Hou, Yu; Niu, Hongyu; Lu, Mei; Xue, Lei; Sun, Qianmei

doi:10.3892/etm.2015.2486

Cited by 15 publications

(14 citation statements)

References 20 publications

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“…Several studies have reported that elevated hs‐CRP and Lp‐PLA2 concentrations are significantly associated with atherosclerosis characterized by artery plaques and artery stenosis 18, 19. Significant associations have also been found between CRP combined with Lp‐PLA2 and atherosclerotic events, such as coronary heart disease and stroke 7, 20.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported that elevated hs-CRP and Lp-PLA2 concentrations are significantly associated with atherosclerosis characterized by artery plaques and artery stenosis. 18,19 Significant associations have also been found between CRP combined with Lp-PLA2 and atherosclerotic events, such as coronary heart disease and stroke. 7,20 An elevated Lp-PLA2 level was shown to be significantly associated with carotid artery plaques, but this association became non-significant when Mendelian randomization methods were adopted.…”

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confidence: 99%

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Association between high‐sensitivity C‐reactive protein, lipoprotein‐associated phospholipase A2 and carotid atherosclerosis: A cross‐sectional study

Liu

Yao

Wang

et al. 2018

J Cellular Molecular Medi

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High‐sensitivity C‐reactive protein (hs‐CRP) and lipoprotein‐associated phospholipase A2 (Lp‐PLA2) have been reported to be independent predictors of atherosclerosis. However, whether the combination of these two markers can improve the prediction of atherosclerosis is unknown. This study aimed to evaluate the association between combining hs‐CRP and Lp‐PLA2 and predicting carotid atherosclerosis. A total of 1982 participants aged ≥40 years were included in this study. Hs‐CRP and Lp‐PLA2 were measured by a high‐sensitivity nephelometry assay and quantitative sandwich enzyme‐linked immunosorbent assay, respectively. Ultrasonography was performed on the bilateral carotid arteries to evaluate stenosis and plaques. Multivariable logistic regression models were used to analyse the association between the combination of the hs‐CRP and Lp‐PLA2 levels and carotid plaques and stenosis. A total of 1579 (79.7%) and 181 (9.1%) subjects had carotid plaques and carotid stenosis, respectively. The group with high hs‐CRP and Lp‐PLA2 levels had the highest prevalence of carotid plaques (90.6%) and stenosis (20.8%). A significant association was found between high hs‐CRP and Lp‐PLA2 levels and carotid stenosis (adjusted odds ratio [OR]: 2.39; 95% confidence interval [CI]: 1.13‐5.09), but this combination was not associated with carotid plaques (OR: 2.62, 95% CI: 0.93‐7.38). The results suggested that the combination of hs‐CRP and Lp‐PLA2 were better predictors than either protein alone with regard to carotid atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Association between high‐sensitivity C‐reactive protein, lipoprotein‐associated phospholipase A2 and carotid atherosclerosis: A cross‐sectional study

Liu

Yao

Wang

et al. 2018

J Cellular Molecular Medi

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“…[ 12 ] The mechanism of action included: the effect on lipid core of plaque [ 13 ] : there was a positive correlation between end arterial lipid deposition and hs-CRP level. Immune reaction which is generated by hs-CRP could reach its peak in plaque rich in lipid; the effect on plaque thickness [ 14 ] : hs-CRP promoted the apoptosis of vascular smooth muscle cell and lowered the synthesis of matrix in fibrous cap, which leads to the thinness of fibrous cap and increase of plaque brittleness; effect on inflammatory response [ 15 ] : inflammatory response which activated by hs-CRP could promote macrophage's elevated secretion of matrix metalloproteinase, which intensified degradation of matrix in fibrous cap, reduced the thickness of fibrous cap, and increased the instability of plaque. Based on the results, it can be seen that the level of serum hs-CRP in T2DM combined with AMI group was significantly higher than that in T2DM group, with the control group being the lowest, indicating the level of serum hs-CRP could reflect the severity of diseases.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of carotid artery ultrasound and hypersensitive C-reactive protein in Type 2 diabetes mellitus patients with acute myocardial infarction in Chinese population

Li¹,

Wang

et al. 2018

Medicine

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Hypersensitive C-reactive protein (hs-CRP) is reported to be significant risk indicators not only for the development of cardiovascular disease, but also for the development or progression of type 2 diabetes. The objective of this study was to analyze the significance of hs-CRP in type 2 diabetes mellitus (T2DM) combined with acute myocardial infarction (AMI).Fifty patients with both T2DM and AMI, 50 patients with T2DM alone, and 50 healthy subjects (control group) were selected.Operating characteristic (ROC) analysis revealed that the sensitivity, specificity, accuracy, and critical value in the diagnosis of T2DM combined with AMI using hs-CRP level were 84.6%, 75.9%, 0.856, and 7.34 mg/L, respectively. For using vulnerable plaque rate, these were 92.7%, 95.3%, 0.923, and 0.52, respectively.hs-CRP play a significant role in the early diagnosis of T2DM combined with AMI.

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“…In the present study, we found that the serum hsCRP and fibrinogen levels were related to CAD severity as higher serum levels of fibrinogen and hsCRP were determined in patients with single-, double- and triple-vessel disease. Liang et al [ 22 ] also observed significantly higher hsCRP levels in patients with double- and triple-vessel disease. Current studies suggest that fibrinogen similar to hsCRP is an important inflammatory factor [ 23 ].…”

Section: Discussionmentioning

confidence: 97%

Evaluation of local carotid stiffness and inflammatory biomarkers in stable angina pectoris

Aslan¹,

Ozcan²,

Ayhan³

et al. 2017

pwki

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IntroductionArterial stiffness (AS) is a well-accepted and reliable predictor of atherosclerotic diseases. Inflammation plays an important role in the development of AS.AimTo evaluate local carotid stiffness (CS) together with fibrinogen and high-sensitivity C-reactive protein (hsCRP) levels in stable angina pectoris (SAP) patients.Material and methodsThe study consisted of 353 consecutive patients with SAP. All underwent coronary angiography (CAG) after the evaluation of local CS parameters and carotid intima-media thickness (IMT) from both common carotid arteries by a real-time echo-tracking system. Baseline inflammatory biomarkers, serum hsCRP and fibrinogen levels were measured. Based on CAG findings, the patients were classified into 4 groups: control subjects with normal coronary arteries (group 1, n = 86), single-vessel disease (group 2, n = 104), double-vessel disease (group 3, n = 95) and triple-vessel disease (group 4, n = 68).ResultsThe mean carotid pulse wave velocity (PWV) in patients with angiographically confirmed coronary artery disease (CAD) was significantly higher than that in patients with normal coronary arteries (7.82 ±1.76 vs. 6.51 ±0.85 cm/s, p = 0.001). The mean carotid IMT was detected to be significantly higher in group 4 patients compared to those in group 1 (p < 0.001) and group 2 (p = 0.001). Significant correlations were observed between both inflammatory biomarkers and the number of diseased vessels and carotid PWV. Using multi-variate analysis, carotid stiffness, carotid IMT, hsCRP and fibrinogen were independently associated with the presence and extent of CAD.ConclusionsLocal CS, carotid IMT, hsCRP and fibrinogen levels are significant predictors of atherosclerotic burden and they may facilitate the identification of high-risk patients for the early diagnosis and prompt treatment of CAD.

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Correlation of high-sensitivity C-reactive protein and carotid plaques with coronary artery disease in elderly patients

Cited by 15 publications

References 20 publications

Association between high‐sensitivity C‐reactive protein, lipoprotein‐associated phospholipase A2 and carotid atherosclerosis: A cross‐sectional study

Association between high‐sensitivity C‐reactive protein, lipoprotein‐associated phospholipase A2 and carotid atherosclerosis: A cross‐sectional study

Diagnostic value of carotid artery ultrasound and hypersensitive C-reactive protein in Type 2 diabetes mellitus patients with acute myocardial infarction in Chinese population

Evaluation of local carotid stiffness and inflammatory biomarkers in stable angina pectoris

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