Correlation of high resolution CT patterns with pulmonary function tests in patients with interstitial lung diseases

Hussein, Khaled; Shaaban, Lamiaa H.; Mohamed, Ehab I.

doi:10.1016/j.ejcdt.2016.01.014

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…The nodular pattern (6%) was the least predominant. The results are similar to the study conducted by Hussain K et al 10 In this study, the mediastinal lymphadenopathy was seen in 84% cases of UIP, 75% cases of COP, 63% cases of NSIP and 25% cases of HSP. It was also seen in all cases of sarcoidosis and silicosis.…”

Section: Discussionsupporting

confidence: 92%

Spectrum of HRCT findings in interstitial lung diseases and their correlation with mediastinal lymphadenopathy

et al. 2019

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Background: Interstitial lung disease (ILD) represents a heterogeneous non-infectious group of acute and chronic diseases affecting the lung parenchyma. ILDs are usually associated with signiﬁcant morbidity and mortality, particularly when ﬁbrosis occurs. ILD is usually associated with mediastinal lymph node enlargement, the extent of lymph node enlargement may correlate to disease activity or progression of fibrosis. In the present study, authors have correlated the spectrum of high-resolution CT findings in ILDs with mediastinal lymph node enlargements.Methods: One hundred and four cases of ILDs confirmed by HRCT findings and pulmonary function tests were included in this study. HRCT was performed using a GE 128 SLICE CT OPTIMA 660 scanner, USA with 1.5 mm collimation at full inspiration. The findings were classified into three groups-fibrotic, ground glassing and nodular pattern. Authors assessed the presence, number and sites of enlarged lymph nodes (short axis ≥10 mm in diameter).Results: The largest subsets of patients were found in the 51-60 age groups. Fibrotic pattern was the most common pattern in this study (50%) followed by ground glassing (44%). Nodular pattern was the least predominant pattern (6%). Lymphadenopathy was seen in 84% of UIP and 63% cases of NSIP. P value was 0.049 which indicates a significant relation between lymphadenopathy and various ILDs. A strong relationship between lymphadenopathy and the predominant fibrotic pattern followed by ground glassing was observed.Conclusions: A significant association was established between lymphadenopathy and the type of ILD where fibrotic pattern had the maximum association.

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Section: Discussionsupporting

confidence: 92%

Spectrum of HRCT findings in interstitial lung diseases and their correlation with mediastinal lymphadenopathy

et al. 2019

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“…These data are in accordance with Hussein et al who found that FVC and DLCO-SB were significantly lower in fibrotic DPLD [28]. Also, Araki et al who studied the effect of pulmonary cysts on DLCO-SB supported this work result [29].…”

Section: Discussionsupporting

confidence: 91%

Diffusion lung capacity for carbon monoxide correlates with HRCT findings in patients with diffuse parenchymal lung disease

Hieba¹,

Shaimaa²,

Dina³

et al. 2020

Egypt J Bronchol

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Diffusion lung capacity for carbon monoxide correlates with HRCT findings in patients with diffuse parenchymal lung disease. Background Diffuse parenchymal lung diseases (DPLDs) affect the alveolar epithelium, pulmonary capillary endothelium, basement membrane, and perivascular and perilymphatic tissues. High-resolution computed tomography (HRCT) of the chest is the gold standard modality for diagnosing DPLD. Pulmonary function tests usually show a restrictive defect in spirometry. Single breath diffusion lung capacity for carbon monoxide (DLCO-SB) technique is used to assess the diffuse parenchymal lung diseases, as there is thickening of the alveolar membrane and diminished total lung capacity due to interstitial processes with severe decline in the transfer factor. The aim of this work was to correlate between Warrick’s HRCT fibrosis score and DLCO-SB in DPLD and to assess the possibility of using DLCO as an only tool to follow up DPLD to avoid repeated radiation exposure of the patients in HRCT chest (decrease need for radiological follow-up) or vice versa. Results This work recruited 89 patients over a period of 10 months duration, 74.2% of them were females. The Warrick’s score, ground-glass opacity, irregular pleural margin, subpleural cyst, honeycombing, and septal and subpleural lines were represented as 96.6%, 70.8%, 55.1%, 49.4%, and 48.3% respectively in HRCT of DPLD. Warrick’s score and its subscores (severity score, extent score, alveolitis score, and fibrosis score) were associated with a highly significant decrease in different pulmonary function indices (FVC, FEV1, TLC, and DLCO) with P value 0.001. A highly significant correlation between DLCO grades and total score grades was found with P value 0.001, and 86.8% of the patients with severe DLCO affection showed severe degree of total fibrosis score. Conclusions Both DLCO-SB and HRCT fibrosis scores were significantly correlated. Lifelong follow-up of function and structure of the lung in DPLD is needed by HRCT and DLCO. In an attempt to minimize repeated radiation exposure and reduce cost, we suggest DLCO to be used alone for longer follow-up periods rather than HRCT chest.

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“…Their prevalence is estimated at (14–50)/100,000 of the population 2 ; the approach and diagnosis of ILDs is still a concern for the pulmonologist, as the proportion of cases that remain undiagnosed is estimated at 15–24% of cases 3 . The association between clinical, radiological, and histologic findings is fundamental for standard diagnosing ILDs 4 . The ILD is classified into idiopathic and nonidiopathic diseases.…”

Section: Introductionmentioning

confidence: 99%

Observational findings of transbronchial lung biopsy in patients with interstitial lung disease: a retrospective study in Aleppo University Hospital

Kashkash¹,

Khorri²

2023

Annals of Medicine &Amp; Surgery

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Background: Clinicians face a significant obstacle when attempting to diagnose interstitial lung disease (ILD) patients. However, a thorough clinical examination together with the proper imaging and diagnostic techniques may provide a reliable diagnosis of a particular kind of ILD, and invasive tests such as rigid bronchoscopy or surgical lung biopsy may not be necessary. The aim of this study is to determine the histologic outcomes of an ILD transbronchial lung biopsy (TBLB) carried out at the university hospital in Aleppo. Methods: This retrospective cohort research was done between 1 January 2020 and 18 April 2022 at the pulmonary department of Aleppo University Hospital, Syria, using patient records. In our study, 174 patients were examined. We included patients over the age of 18 who were referred or admitted to our department at Aleppo University Hospital after being diagnosed with diffuse parenchymal lung disease based on high-resolution computed tomography and clinical symptoms, while excluding other respiratory diseases such as tuberculosis and coronavirus disease 2019. Results: Patients in the research were 53±7.1 years old on average. Cough and dyspnea were the most common clinical complaints among the patients, which accounted for 79.12 and 78.16%, respectively. A significant fraction of ground-glass opacity was detected on the high-resolution computed tomography, amounting to 102 (58.62%) and 74 (42.53%) for the reticular lesions, respectively. As a complication there were 40 patients with bleeding, of whom 24 had moderate bleeding, and 11 had major bleeding. We also had three patients with pneumothorax. The diagnostic yield of the TBLB in our ILD patients was 66.66%. Conclusion: An adequate diagnostic accuracy (66.66%) was detected in the TBLB in confirming the diagnosis of ILD; in addition, the bleeding was the most prevalent complication of this procedure. More interventional studies are needed to compare the diagnostic accuracy of this procedure with other invasive and noninvasive diagnostic methodologies of ILD.

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Correlation of high resolution CT patterns with pulmonary function tests in patients with interstitial lung diseases

Cited by 4 publications

References 17 publications

Spectrum of HRCT findings in interstitial lung diseases and their correlation with mediastinal lymphadenopathy

Spectrum of HRCT findings in interstitial lung diseases and their correlation with mediastinal lymphadenopathy

Diffusion lung capacity for carbon monoxide correlates with HRCT findings in patients with diffuse parenchymal lung disease

Observational findings of transbronchial lung biopsy in patients with interstitial lung disease: a retrospective study in Aleppo University Hospital

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