“…In the study of Chieng J et al, FNAC predicted malignancy with a sensitivity, speci city, PPV, NPV, false positive rate, false negative rate and total accuracy of 90.7%, 53.6%, 43.3%, 93.7%, 46.4%, 9.3% and 64.1%, respectively [37]. However, FNAC is considered to be "uninterpretable" in 10 to 20% of cases or simply "suspicious" in 9 to 38% of cases [38].In addition, it is currently estimated that cytologically indeterminate results are diagnosed in up to 25% to 30% of thyroid biopsies [39,40].Therefore, the use of molecular markers is important for improving diagnostic accuracy. In this study, blood E2F3 mRNA predicted malignancy with a sensitivity, speci city, PPV, NPV, and accuracy of 90%, 60.9%, 70.5%, 85.47%, and 74.4%, respectively.…”