Correlation of F4-neuroprostanes levels in cerebrospinal fluid with outcome of aneurysmal subarachnoid hemorrhage in humans

Hsieh, Yi-Ping; Lin, Chih‐Lung; Shiue, An-Li; Yin, Huiyong; Morrow, Jason D.; Hsu, Jee-Ching; Hsieh, Tsung-Che; Wei, Hsing-Ju; Yen, Hsiu-Chuan

doi:10.1016/j.freeradbiomed.2009.06.026

Cited by 47 publications

(41 citation statements)

References 41 publications

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“…These data confirm that CNS injury, in case of aSAH or TBI, results in increased OS and as DHA is the brain major PUFA, F 4 -NeuroP levels in CSF could be a much more specific indicator of neurological dysfunction than F 2 -IsoP. Hsieh et al have shown that increased F 4 -NeuroPs in CSF of patients with aSAH correlated with poor neurological outcome (Hsieh et al, 2009). They suggested that F 4 -NeuroPs might be more useful than F 2 -IsoPs in CSF to predict outcome and interpret the role of hemorrhage in aSAH.…”

Section: Neuroprostanes and Isofuranssupporting

confidence: 56%

Non enzymatic metabolites of polyunsaturated fatty acids: friend or foe

Bultel-Poncé¹,

Guy²,

Oger³

et al. 2015

OCL

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-Under condition of oxidative stress, free radical mediated peroxidation of polyunsaturated fatty acids generates in vivo, cyclic metabolites like the isoprostanes, neuroprostanes, dihomo-isoprostanes, isofuranes among a large number of key products which participate in many pathophysiological processes. These metabolites display a wide range of biological actions, and some of them are now the most reliable indicators of oxidative stress in humans. In this review, we will discuss several key points of our understanding of those cyclic polyunsaturated fatty acids derivatives, going from multi-step syntheses, analytical chemistry and biological activities.Keywords: biomarkers / polyunsaturated fatty acid / radical peroxidation / isoprostanes / neuroprostanes / isofurans / total synthesis Résumé -La peroxydation radicalaire des acides gras polyinsaturés, constituants majeurs des membranes cellulaires, conduit à de nombreux métabolites, comme les isoprostanes, les neuroprostanes, les dihomo-isoprostanes, les isofuranes. Certaines isoprostanes sont à présent des marqueurs du stress oxydant cellulaire les plus significatifs utilisés en clinique. Ces lipides oxygénés possèdent également un large spectre d'activités biologiques. Cette revue fera le point sur notre dernière stratégie de synthèse organique multi-étapes pour obtenir ces molécules pures et sur des résultats récents issus de collaborations avec des collègues biologistes et cliniciens.

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Section: Neuroprostanes and Isofuranssupporting

confidence: 56%

Non enzymatic metabolites of polyunsaturated fatty acids: friend or foe

Bultel-Poncé¹,

Guy²,

Oger³

et al. 2015

OCL

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“…The HI induced a significant increase in F 4 -NeuroPs in both the right and the left side of the cerebral cortex [30]. Studies in humans, based on GC-MS analysis of CSF (cerebrospinal fluid) samples, have shown that F 4 -NeuroPs were increased in aSAH (aneurysmal subarachnoid hemorrhage) patients and in traumatic brain injury patients compared with their controls [31,32]. In the same sense, a prior study showed that plasma F 4 -NeuroPs were significantly increased in RTT (Rett syndrome) patients compared to controls [33].…”

Section: Discussionmentioning

confidence: 99%

Dihomo-isoprostanes—nonenzymatic metabolites of AdA—are higher in epileptic patients compared to healthy individuals by a new ultrahigh pressure liquid chromatography–triple quadrupole–tandem mass spectrometry method

Medina

Miguel-Elízaga

Oger

et al. 2015

Free Radical Biology and Medicine

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“…The F 2 -IsoPs derive from oxidative damage to both neural and nonneural cells in the brain, including vascular cells and blood cells, since AA is present in all cells. In this regard, Hsieh et al (3) showed that increased F 4 -NeuroPs in CSF of patients with aSAH correlated with poor neurological outcome and suggested that F 4 -NeuroPs might be more useful than F 2 -IsoPs in CSF to predict outcome and interpret the role of hemorrhage in aSAH.…”

Section: Corcoran Et Almentioning

confidence: 99%

Are Isofurans and Neuroprostanes Increased After Subarachnoid Hemorrhage and Traumatic Brain Injury?

Corcoran

Mas

Barden

et al. 2011

Antioxidants & Redox Signaling

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Current diagnostic tools to assess neurological injury after aneurysmal subarachnoid hemorrhage (aSAH) and traumatic brain injury (TBI) have poor discriminatory abilities. Free radicals are associated with the pathophysiology of secondary damage after brain trauma. We examined cerebrospinal fluid (CSF) lipid markers of oxidative stress, isofurans (IsoFs), F 4 -neuroprostanes (F 4 -NeuroPs), and F 2 -isoprostanes (F 2 -IsoPs), in two casecontrolled studies in patients with aSAH or severe TBI. Patients with aSAH (n = 18) or TBI (n = 18) were age and gender matched with separate control groups. CSF samples were collected from patients within 24 h of the injury. CSF IsoFs and F 4 -NeuroPs were increased in aSAH patients compared with their controls. In TBI patients, IsoFs and F 4 -NeuroPs were increased compared with their controls. F 2 -IsoPs were increased in aSAH patients, but not in TBI patients, compared with their respective controls. CSF IsoFs and F 4 -NeuroPs are consistently increased after a catastrophic central nervous system injury. These results suggest their measurement may enhance the management of unconscious patients in neurological care. Antioxid. Redox Signal. 15, 2663-2667. Brain Injury and Oxidative StressA neurysmal subarachnoid hemorrhage (aSAH) and traumatic brain injury (TBI) are associated with devastating central nervous system (CNS) injury. aSAH is associated with a high mortality rate and substantial lifelong morbidity in survivors. TBI is a major health and socioeconomic problem more prevalent in young male adults. The most common secondary injury resulting from aSAH and TBI is attributable to vasospasm-induced microvascular injury and cerebral ischemia. Diagnostic tools use surrogate measures such as intracranial pressure changes and interval changes in neuroimaging, which have poor discriminatory abilities.After acute brain injury, there is a disruption of calcium homeostasis, excitotoxicity from release of neurotransmitters such as glutamate, overproduction of reactive oxygen species (ROS), and opening of the mitochondrial permeability transition pore, all key factors in promoting mitochondrial InnovationAneurysmal subarachnoid hemorrhage (aSAH) and traumatic brain injury (TBI) associate with catastrophic central nervous system (CNS) injury. Diagnostic tools to assess neurological injury after aSAH and TBI currently have poor discriminatory capacity. Free radicals are likely to be involved in mediating secondary damage after brain trauma. In two case-controlled studies of patients with aSAH or severe TBI, we examined lipid markers of oxidative stress, isofurans (IsoFs), F 4 -neuroprostanes (F 4 -NeuroPs), and F 2 -isoprostanes (F 2 -IsoPs), in cerebrospinal fluid (CSF) samples. In aSAH and TBI patients, IsoFs and F 4 -NeuroPs were increased compared with their respective controls. F 2 -IsoPs were increased in aSAH patients, but not in TBI patients. Increased IsoFs and F 4 -NeuroPs in the CSF of these patients is a new and important finding that may have important clinical imp...

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Correlation of F4-neuroprostanes levels in cerebrospinal fluid with outcome of aneurysmal subarachnoid hemorrhage in humans

Cited by 47 publications

References 41 publications

Non enzymatic metabolites of polyunsaturated fatty acids: friend or foe

Non enzymatic metabolites of polyunsaturated fatty acids: friend or foe

Dihomo-isoprostanes—nonenzymatic metabolites of AdA—are higher in epileptic patients compared to healthy individuals by a new ultrahigh pressure liquid chromatography–triple quadrupole–tandem mass spectrometry method

Are Isofurans and Neuroprostanes Increased After Subarachnoid Hemorrhage and Traumatic Brain Injury?

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