Correlation of endothelin-1 mRNA expression and bone structure in advanced osteoarthritis

Vukelic, Lucian; Šoša, Ivan; Cvijanović, Olga; Mađarević, Tomislav; Jotanović, Zdravko; Šarunić, Alenka Vukelić; Štifter, Sanja; Cvek, Sanja Zoričić; Đudarić, Luka; Šestan, Branko; Bobinac, Dragica

doi:10.1016/j.mehy.2011.08.015

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…There is certainly a lack of prospective evidence that links plaque characteristics to the rate of carotid restenosis. In order to overcome this, it is necessary to implement methodology similar to that found in some studies [18] using endarterectomised tissue samples. We speculate that the composition of an atherosclerotic plaque is directly responsible for the lesion's capacity to develop carotid restenosis.…”

Section: Resultsmentioning

confidence: 99%

Predicting carotid restenosis by comparison of plaque MCP-1 mRNA expression and serum levels

et al. 2013

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Section: Resultsmentioning

confidence: 99%

Predicting carotid restenosis by comparison of plaque MCP-1 mRNA expression and serum levels

et al. 2013

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“…One role and mechanism of hypertension in MetS is considered to be impaired bone metabolism due to interrupted blood flow in the subchondral bone, while another mechanism involves apoptosis of osteoblasts. 62,63 Recently, we showed that the renin–angiotensin system (RAS) component is expressed in mouse growth plates. 64 We also showed that the local RAS was involved in differentiation of chondrocytes in the ataxia–telangiectasia group D complementing cell line.…”

Section: Common Molecules Between Mets In Oa and Lox-1/ox-ldlmentioning

confidence: 99%

The role of oxidation of low-density lipids in pathogenesis of osteoarthritis: A narrative review

Hashimoto

Akagi

2020

J Int Med Res

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Osteoarthritis (OA) is a chronic joint disorder that causes degeneration of cartilage, synovial inflammation, and formation of osteophytes. Aging, obesity, and sex are considered the main risk factors of OA. Recent studies have suggested that metabolic syndrome (MetS) disorders, such as hypertension, hyperlipidemia, diabetes mellitus, and obesity, may be involved in the pathogenesis and progression of OA. MetS disorders are common diseases that also result in atherosclerosis. Researchers believe that OA and atherosclerosis have underlying similar molecular mechanisms because the prevalence of both diseases increases with age. Oxidation of low-density lipoprotein (ox-LDL) is believed to play a role in the pathogenesis of atherosclerosis. Recent reports have shown that ox-LDL and low-density lipoprotein receptor 1 (LOX-1) are involved in the pathogenesis of OA. The purpose of this narrative review is to summarize the current understanding of the role of the LOX-1/ox-LDL system in the pathogenesis of OA and to reveal common underlying molecular pathways that are shared by MetS in OA and the LOX-1/ox-LDL system.

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“…Bellisai et al [22] reported that ET-1 increases TNF-α synthesis in macrophages and monocytes, while Nakano et al [23] suggested that proinflammatory cytokines increase ET-1 expression. The induction of nitric oxide synthase by ET-1 leads to excessive nitric oxide production, activation of MMP-1 and MMP-13 synthesis, reduction of the interstitial fluid flow through a vasoconstrictive effect, and acceleration of cartilage destruction by the induction of osteocyte hypoxia leading to degeneration are among the hypotheses that aimed to explain the process [24]. It can be suggested that ET-1, a significant degeneration factor, could also be associated with lumbar pathologies.…”

Section: Introductionmentioning

confidence: 99%

Serum Endothelin-1 Level Can Reflect the Degree of Lumbar Degeneration: A Cross-Sectional Study

Yıldırım Uslu,

Gülkesen,

Akgol

et al. 2024

Cureus

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BackgroundEndothelin-1 (ET-1) is an agent closely associated with inflammation and has recently been recognized as a significant factor in degenerative processes. This study aimed to investigate the correlation between serum ET-1 level and radiological and clinical manifestations of lumbar disc herniation (LDH) and intervertebral disc degeneration (IDD) pathologies. MethodologyThe study was conducted with 50 healthy controls and 50 LDH patients. The pain level of the patients was analyzed with the Visual Analog Scale (VAS), and their functionality was analyzed with the Oswestry Disability Index (ODI). The disc degeneration and disc herniation grades were determined using magnetic resonance imaging. Serum ET-1 levels of the participants were measured using the enzyme-linked immunosorbent assay method. ResultsET-1 level was significantly higher in the patient group compared to the controls (p < 0.01). A positive correlation was determined between serum ET-1 level and Pfirrmann grade in the patient group (p < 0.01). No correlation was determined between the MacNab grade, VAS, and ODI scores and ET-1 (p = 0.397, p = 0.137, and p = 0.208, respectively). There was no significant difference between the serum ET-1 levels of the patients with or without neurological deficits (p = 0.312). ConclusionsThe correlation between the serum ET-1 levels and IDD grade suggested that the former could serve as a biomarker to determine the degree of degeneration in the future. However, further research is required to determine the underlying mechanisms.

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Correlation of endothelin-1 mRNA expression and bone structure in advanced osteoarthritis

Cited by 4 publications

References 18 publications

Predicting carotid restenosis by comparison of plaque MCP-1 mRNA expression and serum levels

Predicting carotid restenosis by comparison of plaque MCP-1 mRNA expression and serum levels

The role of oxidation of low-density lipids in pathogenesis of osteoarthritis: A narrative review

Serum Endothelin-1 Level Can Reflect the Degree of Lumbar Degeneration: A Cross-Sectional Study

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