Correlation of endorectal 2D JPRESS findings with pathological Gleason scores in prostate cancer patients

Nagarajan, Rajakumar; Gómez, Ana M.; Raman, Steve; Margolis, Daniel; McClure, Tim; Thomas, M. Albert

doi:10.1002/nbm.1446

Cited by 13 publications

(10 citation statements)

References 46 publications

(51 reference statements)

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“…Nagarajan et al . have shown a decrease of Spm in PCa patients of higher GS (4 + 3) compared with lower GS (3 + 4) using 2D J‐resolved spectroscopy. High levels of Spm are found in the healthy prostatic ducts and the observed variations of Spm in cancer may be due to the loss of ductal morphology or a reduction in the secretion of polyamines .…”

Section: Single Voxel Based 2d Mr Spectroscopy Of Prostate Cancermentioning

confidence: 94%

“…Different versions of multidimensional techniques have been reported to overcome the signal overlap and to detect several metabolites more unambiguously than conventional MRSI techniques including spectral editing . Multidimensional MRS enables detection of a larger number of resonances from multiple metabolites with improved spectral resolution than one‐dimensional (1D) MRS and a more efficient and accurate identification and quantification of metabolites.…”

Section: Single Voxel Based 2d Mr Spectroscopy Of Prostate Cancermentioning

confidence: 99%

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Multidimensional MR spectroscopic imaging of prostate cancer in vivo

et al. 2013

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Prostate cancer (PCa) is the second most common type of cancer among men in the United States. A major limitation in the management of PCa is an inability to distinguish, early on, cancers that will progress and become life threatening. One-dimensional (1D) proton ((1)H) MRS of the prostate provides metabolic information such as levels of choline (Ch), creatine (Cr), citrate (Cit), and spermine (Spm) that can be used to detect and diagnose PCa. Ex vivo high-resolution magic angle spinning (HR-MAS) of PCa specimens has revealed detection of more metabolites such as myo-inositol (mI), glutamate (Glu), and glutamine (Gln). Due to the J-modulation and signal overlap, it is difficult to quantitate Spm and other resonances in the prostate clearly by single- and multivoxel-based 1D MR spectroscopy. This limitation can be minimized by adding at least one more spectral dimension by which resonances can be spread apart, thereby increasing the spectral dispersion. However, recording of multivoxel-based two-dimensional (2D) MRS such as J-resolved spectroscopy (JPRESS) and correlated spectroscopy (L-COSY) combined with 2D or three-dimensional (3D) magnetic resonance spectroscopic imaging (MRSI) using conventional phase-encoding can be prohibitively long to be included in a clinical protocol. To reduce the long acquisition time required for spatial encoding, the echo-planar spectroscopic imaging (EPSI) technique has been combined with correlated spectroscopy to give four-dimensional (4D) echo-planar correlated spectroscopic imaging (EP-COSI) as well as J-resolved spectroscopic imaging (EP-JRESI) and the multi-echo (ME) variants. Further acceleration can be achieved using non-uniform undersampling (NUS) and reconstruction using compressed sensing (CS). Earlier versions of 2D MRS, theory of 2D MRS, spectral apodization filters, newer developments and the potential role of multidimensional MRS in PCa detection and management will be reviewed here.

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Section: Single Voxel Based 2d Mr Spectroscopy Of Prostate Cancermentioning

confidence: 94%

Section: Single Voxel Based 2d Mr Spectroscopy Of Prostate Cancermentioning

confidence: 99%

Multidimensional MR spectroscopic imaging of prostate cancer in vivo

et al. 2013

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“…These studies support the complementary nature of MRSI to multi-parametric imaging, primarily providing additional specificity for tumor diagnosis when used with T2WI and improved sensitivity for tumor detection when compared to prostate biopsy. MRSI has also been shown to be increasingly abnormal with increasing GS of prostate adenocarcinoma [34]. Some relative disadvantages of the technique are its relative complexity of implementation and additional time for acquisition.…”

Section: Mr Spectroscopic Imaging (Mrsi)mentioning

confidence: 99%

“…In each of these voxels, the concentration of metabolites including citrate, choline, creatine, and polyamines is quantified and displayed as a spectral tracing as relative parts per million. Other potentially useful metabolites such as spermine may also be detectable and are under investigation [34]. Relative concentration can be determined from the area under the respective peaks detected in the spectral trace.…”

Section: Mr Spectroscopic Imaging (Mrsi)mentioning

confidence: 99%

Radical prostatectomy: value of prostate MRI in surgical planning

et al. 2011

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The introduction of serum prostate-specific antigen to the prostate cancer screening algorithm has led to an increase in prostate cancer diagnosis as well as a migration toward lower-stage cancer at the time of diagnosis. This stage migration has coincided with changes in treatment options; these include active surveillance, new therapies, and advances in surgical techniques. Use of robot-assisted radical prostatectomy (RARP) as a surgical technique has seen a significant increase over the past several years: the number of patients undergoing RARP has risen from 1% to 40% of all prostatectomies from 2001-2006 to as many as 80% in 2010. The robotic interface provides a 3D magnified view of the surgical field, intuitive instrument manipulation, motion scaling, tremor filtration, and excellent dexterity and range of motion. However, in some cases, the lack of tactile (haptic) feedback may limit the surgeon's decision making ability in assessing malignant involvement of the neurovascular bundles. Pre-operative planning relies on nomograms based on limited clinical and prostate biopsy information. The surgical decision to spare or resect the neurovascular bundles is based on clinical information which is not spatially or anatomically based. Advances in magnetic resonance imaging (MRI) may provide spatially localized information to fill this void and aid surgical planning, particularly for robotic surgeons. In this review, we discuss the potential role of pre-operative MRI in surgical planning for radical prostatectomy.

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“…These enzymes are involved in the biosynthesis and breakdown pathways of the major membrane phospholipid, phosphatidylcholine. A trend towards increasing total choline to citrate, a compound that is found in normal prostate tissue was observed with increasing Gleason score [89]. …”

Section: Identification Of Primary Lesions That Are Most Likely Tomentioning

confidence: 99%

Molecular and functional imaging of invasion and metastasis: Windows into the metastatic cascade

Stasinopoulos¹,

Penet²,

Krishnamachary³

et al. 2011

CBM

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The ability of cancer cells to invade, metastasize, and form distant colonies, is one of the key characteristics that confers lethality to cancer. Metastatic cancer cells typically become refractory to treatment. The metastatic cascade is a multi-step process that is governed by events within the cancer cell, the tumor microenvironment, and the distant environments that are invaded and colonized by the cancer cells. Noninvasive imaging techniques are facilitating a close examination of the stepwise journey of the cancer cell from the primary tumor to the distant metastatic site. Here we have discussed the metastatic process, and how molecular and functional imaging of cancer are providing new insights into the metastatic cascade that can be exploited for treatment of metastatic disease.

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Correlation of endorectal 2D JPRESS findings with pathological Gleason scores in prostate cancer patients

Cited by 13 publications

References 46 publications

Multidimensional MR spectroscopic imaging of prostate cancer in vivo

Multidimensional MR spectroscopic imaging of prostate cancer in vivo

Radical prostatectomy: value of prostate MRI in surgical planning

Molecular and functional imaging of invasion and metastasis: Windows into the metastatic cascade

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