Correlation of echocardiography parameters with cardiac magnetic resonance imaging in transfusion‐dependent thalassaemia major

Aessopos, Athanasios; Giakoumis, Anastasios; Fragodimitri, Christina; Karabatsos, Fotis; Hatziliami, Antonia; Yousef, Jacqueline; Gotsis, Efstathios D.; Berdoukas, Vasilios; Karagiorga, Markisia

doi:10.1111/j.1600-0609.2006.00770.x

Cited by 17 publications

(20 citation statements)

References 27 publications

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“…Although some of these studies have demonstrated a significant correlation (25)(26)(27), others have not (11,28). The main limitation of TDI parameters is their dependence on heart rate.…”

Section: Discussionmentioning

confidence: 99%

The relation of color m-mode flow propagation with cardiac iron load in patients with thalassemia major

Özbek

Acar²,

Kayrak³

et al. 2011

Diagn Interv Radiol

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“…Although some of these studies have demonstrated a significant correlation (25)(26)(27), others have not (11,28). The main limitation of TDI parameters is their dependence on heart rate.…”

Section: Discussionmentioning

confidence: 99%

The relation of color m-mode flow propagation with cardiac iron load in patients with thalassemia major

Özbek

Acar²,

Kayrak³

et al. 2011

Diagn Interv Radiol

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“…There are only few other reports comparing echocardiographic diastolic function indices with myocardial T2*. Aessopos et al (26) related a variety of parameters including E, A, and E/A but not tissue-Doppler indices to myocardial T2*. They found statistically significant correlations between A and E/A versus T2* but these were not strong (r Ͻ 0.5) and lacked discriminatory power to identify patients with myocardial iron overload yet normal systolic function.…”

Section: Figure 2 Receiver-operating Characteristic Curve Analysismentioning

confidence: 99%

Relationship of Magnetic Resonance Imaging Estimation of Myocardial Iron to Left Ventricular Systolic and Diastolic Function in Thalassemia

Leonardi

Margossian

Colan

et al. 2008

JACC: Cardiovascular Imaging

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“…(5-7) Left ventricular dysfunction as noted on echocardiography is more evident in patients with severe cardiac siderosis. (8) Once symptomatic heart failure develops mortality is very high. (9) It is highly desirable to identify these patients early in the course of cardiac iron deposition and aggressively treat with iron chelation.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal monitoring of cardiac siderosis using cardiovascular magnetic resonance T2* in patients with thalassemia major on various chelation regimens: A 6‐year study

Ambati

Randolph²,

Mennitt³

et al. 2013

American J Hematol

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Cardiovascular magnetic resonance (CMR) and hepatic magnetic resonance imaging (MRI) has become a reliable non-invasive tool to monitor iron excess in thalassemia major (TM) patients. However, long-term studies are lacking. We reviewed CMR and hepatic MRI T2* imaging on 54 TM patients who had three or more annual measurements. They were managed on various chelation regimens. Patients were grouped according to their degree of cardiac siderosis: severe (T2*<10msec), mild to moderate (T2*=10-20 msec) and no cardiac siderosis (T2*>20msec). We looked at the change in cardiac T2*, liver iron concentration (LIC) and left ventricular ejection fraction (LVEF) at years 3 and 5. In patients with severe cardiac siderosis, cardiac T2* (mean±SD) improved from 6.9±1.6 at baseline to 13.6±10.0 by year 5, mean ΔT2*=6.7 (p-value 0.04). Change in cardiac T2* at year 3 was not significant in the severe group. Patients with mild to moderate cardiac siderosis had mean cardiac T2* of 14.6±2.9 at baseline which improved to 26.3±9.5 by year 3, mean ΔT2*=11.7 (p-value 0.01). At baseline, median LIC (mg/gm dw) in patients with severe, mild-moderate and no cardiac siderosis was 3.6, 2.8 and 3.3 while LVEF (mean±SD) (%) was 56.3±10.1, 60±5 and 66±7.6 respectively. No significant correlation was noted between Δ cardiac T2* and Δ LIC, Δ cardiac T2* and Δ LVEF at years 3 and 5. Throughout the observation period, patients with no cardiac siderosis maintained their cardiac T2* above 20msec. The majority of patients with cardiac siderosis improve cardiac T2* over time with optimal chelation.

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Correlation of echocardiography parameters with cardiac magnetic resonance imaging in transfusion‐dependent thalassaemia major

Cited by 17 publications

References 27 publications

The relation of color m-mode flow propagation with cardiac iron load in patients with thalassemia major

The relation of color m-mode flow propagation with cardiac iron load in patients with thalassemia major

Relationship of Magnetic Resonance Imaging Estimation of Myocardial Iron to Left Ventricular Systolic and Diastolic Function in Thalassemia

Longitudinal monitoring of cardiac siderosis using cardiovascular magnetic resonance T2* in patients with thalassemia major on various chelation regimens: A 6‐year study

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