The relation of color m-mode flow propagation with cardiac iron load in patients with thalassemia major

Özbek, Orhan; Acar, Kadir; Kayrak, Mehmet; Özbek, Seda; Gül, Enes Elvin; Uçar, Ramazan; Paksoy, Yahya

doi:10.4261/1305-3825.dir.4581-11.1

Cited by 4 publications

(4 citation statements)

References 31 publications

(22 reference statements)

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“…The present study showed that there was no correlation between other echocardiographic parameters and MRI T2* value. These findings agreed with Karan et al, [18] who found that the correlation was not strong, and the echo parameters showed low sensitivity. This study showed that, there was no correlation between serum ferritin level with any of echocardiographic parameters.…”

Section: Discussionsupporting

confidence: 92%

Cardiac Iron Overload: Correlation between MRI T2* & Two Dimensional Strain Echocardiography in Children with b-Thalassemia Major

El-Shanshory¹,

El-Shafey

2018

The Medical Journal of Cairo University

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Background: β -thalassemia is a group of inherited blood disorders that causes iron overload in the heart. Development of overt heart failure is delayed till the second decade of life. Early detection of cardiac iron overload is necessary before development of heart failure.Aim of the Study: Was to evaluate cardiac function in children with β -thalassemia major having iron overload and to Compare MRI T2* and doppler echocardiography in demonstration of iron deposition in cardiac muscles in those patients.Patients and Methods: Fifty children with thalassemia major were subjected to history taking, clinical assessment, laboratory assessment, Doppler echocardiography and MRI for cardiac iron load assessment.Results: There is a negative correlation between cardiac MRI T2* with age, ferritin and serum iron level. As regard correltion between MRI and doppler echocardiography there is a positive correlation between MRI T2* and diastolic echocardiographic parameters Tei index in patients with thalassemia Major. Conclusion:There is a significant correlation between MRI T2* and Doppler echocardiography in patients with β thalassemia major.

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Section: Discussionsupporting

confidence: 92%

Cardiac Iron Overload: Correlation between MRI T2* & Two Dimensional Strain Echocardiography in Children with b-Thalassemia Major

El-Shanshory¹,

El-Shafey

2018

The Medical Journal of Cairo University

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“…Lastly, for studies including iron overload patients most T 2 * measurements were performed in the intraventricular septum for reproducibility, because the lateral wall often contains dephasing artefacts. Nevertheless, some studies reported an average of the mid-ventricular SAx slice [87,115,119,134] or the entire myocardium [106,125,[127][128][129][130][131][132], which especially on 3 T [127] could lead to some unrealistic T 2 * values due to aforementioned artefacts.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular magnetic resonance native T2 and T2* quantitative values for cardiomyopathies and heart transplantations: a systematic review and meta-analysis

Snel

Boomen

Hernández

et al. 2020

Journal of Cardiovascular Magnetic Resonance

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Background: The clinical application of cardiovascular magnetic resonance (CMR) T 2 and T 2 * mapping is currently limited as ranges for healthy and cardiac diseases are poorly defined. In this meta-analysis we aimed to determine the weighted mean of T 2 and T 2 * mapping values in patients with myocardial infarction (MI), heart transplantation, non-ischemic cardiomyopathies (NICM) and hypertension, and the standardized mean difference (SMD) of each population with healthy controls. Additionally, the variation of mapping outcomes between studies was investigated. Methods: The PRISMA guidelines were followed after literature searches on PubMed and Embase. Studies reporting CMR T 2 or T 2 * values measured in patients were included. The SMD was calculated using a random effects model and a meta-regression analysis was performed for populations with sufficient published data. Results: One hundred fifty-four studies, including 13,804 patient and 4392 control measurements, were included. T 2 values were higher in patients with MI, heart transplantation, sarcoidosis, systemic lupus erythematosus, amyloidosis, hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM) and myocarditis (

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“…Shahmohammadi et al [ 23 ] showed that evaluation of diastolic cardiac function is useful for early detection of LV cardiac dysfunction. Ozbek et al [ 30 ] showed that diastolic function can be impaired owing to cardiac siderosis even when T2*>20 ms. The present study showed that echocardiography is able to diagnose heart diastolic dysfunction of thalassemia patients when T2*MRI findings are normal.…”

Section: Discussionmentioning

confidence: 99%

Optimal method for early detection of cardiac disorders in thalassemia major patients: magnetic resonance imaging or echocardiography?

et al. 2014

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BackgroundHeart failure resulting from myocardial iron deposition is the most important cause of death in β-thalassemia major (TM) patients. Cardiac T2*magnetic resonance imaging (MRI), echocardiography, and serum ferritin level serve as diagnostic methods for detecting myocardial iron overload. In this study, we aimed to evaluate the relationship between the above-mentioned methods.MethodsT2*MRI and echocardiographic measurement of left ventricular (LV) systolic and diastolic function were performed in 63 patients. Serum ferritin level was measured. The relationships between all assessments were evaluated.ResultsThere were 40 women and 23 men with a mean age of 23.7±5.1 years (range, 15-35 years). There was no statistically significant correlation between serum ferritin level and LV systolic and diastolic function (P=0.994 and P=0.475, respectively). T2*MRI results had a significant correlation with ferritin level; 63.6% of patients with serum ferritin level >2,000 ng/mL had abnormal cardiac MRI, while none of the patients with ferritin level <1,000 ng/mL had abnormal cardiac MRI (P=0.001). There was no significant correlation between MRI findings and LV systolic function (P=1.00). However, we detected a significant difference between LV diastolic function and cardiac siderosis (P=0.03)ConclusionMRI findings are a good predictor of future cardiac dysfunction, even in asymptomatic TM patients; however, diastolic dysfunction may happen prior to cardiac siderosis in some patients, and echocardiography is able to diagnose this diastolic dysfunction while T2*MRI shows normal findings.

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The relation of color m-mode flow propagation with cardiac iron load in patients with thalassemia major

Cited by 4 publications

References 31 publications

Cardiac Iron Overload: Correlation between MRI T2* & Two Dimensional Strain Echocardiography in Children with b-Thalassemia Major

Cardiac Iron Overload: Correlation between MRI T2* & Two Dimensional Strain Echocardiography in Children with b-Thalassemia Major

Cardiovascular magnetic resonance native T2 and T2* quantitative values for cardiomyopathies and heart transplantations: a systematic review and meta-analysis

Optimal method for early detection of cardiac disorders in thalassemia major patients: magnetic resonance imaging or echocardiography?

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