Correlation of e Antigen, DNA Polymerase Activity, and Dane Particles in Chronic Benign and Chronic Active Type B Hepatitis Infections

Tong, Myron J.; Stevenson, Douglas; Gordon, Irving

doi:10.1093/infdis/135.6.980

Cited by 58 publications

(18 citation statements)

References 16 publications

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“…HBV specific DNAP activity can be detected in the serum of some patients chronically infected with HBV and represents a marker of active replication of the complete virus (Kaplan etal., 1973). Its presence is often independent of the severity of the associated liver disease (Tong et al, 1977;Alberti et al, 1978), the highest levels usually being found in immunosuppressed patients (Nordenfelt and Kjellen, 1975) …”

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confidence: 99%

Changes in hepatitis B virus DNA polymerase in relation to the outcome of acute hepatitis type B.

Alberti¹,

Diana²,

Eddleston³

et al. 1979

Gut

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SUMMARY Serum levels of hepatitis B virus specific DNA polymerase and hepatitis B e antigen were studied serially in 34 patients with hepatitis B virus infection-20 who had the acute illness and recovered, seven who died with fulminant disease, three who died as a result of subacute hepatic necrosis, and four who went on to develop chronic active hepatitis. DNA polymerase activity was present in 16 (80 %) and HBeAg in 13 (65 %) of the uncomplicated cases at presentation and in all of those patients from whom the initial sample was obtained before the peak in aminotransferase. Both markers disappeared after 30 days from the onset but DNAP remained persistently positive during a follow-up period of four to 10 months in the four patients who progressed to chronic hepatitis. These results indicate that DNAP and HBeAg are transiently present in all cases of acute hepatitis B. Only their persistence after the acute episode could represent a useful prognostic marker of chronicity. In this respect, DNAP was more reliable in our patients than HBeAg. In uncomplicated acute hepatitis, the peak in DNAP levels, which defines the time of maximum virus replication in the liver, preceded the peak in aminotransferase levels. Among the 10 patients who developed massive liver damage after hepatitis B infection, DNAP was detected in five of the seven with fulminant hepatitis, with enzyme levels that were comparable with those observed in uncomplicated acute hepatitis at presentation, but not in the cases of subacute hepatic necrosis. These findings are consistent with the hypothesis that in hepatitis B infection, liver damage, whatever the severity, is not directly related to the degree of virus replication.

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confidence: 99%

Changes in hepatitis B virus DNA polymerase in relation to the outcome of acute hepatitis type B.

Alberti¹,

Diana²,

Eddleston³

et al. 1979

Gut

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“…The e-antigen, recognized as an integral part of the hepatitis B virus (HBV) or Dane particle [Neurath and Strick, 1979;Takahashi et al, 19791 is detectable in the serum of the patient soon after HBV infection and is linked with viral activity [Tong et al, 1977; Nordenfelt et al, 1976; Cappel et al, 19771. AntiHBe in the serum appears to be a sign of arrested HBV infection [Feinman et al, 1975;Trepo et al, 1976;Cappel et al, 19771.…”

Section: Discussionmentioning

confidence: 99%

Anti-DNA, anti-HBc correlations with RIA-detected HBeAg and anti-HBe in chronic HBsAg carriers

Villarejos¹,

Andersen-Visoná²,

Serra³

et al. 1980

J. Med. Virol.

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The interrelations of 1) antibody to hepatitis B core antigen (HBcAg)--anti-HBc; 2) single-stranded DNA-binding antibodies (anti-DNA); and 3) the e-antigen/antibody system--hepatitis B e antigen (HBeAg) and antibody (anti-HBe), were studied in 150 hepatitis B surface antigen (HBsAg) carriers, in 43 of whom diagnostic liver biopsies had been performed. There was a good correlation between titers of anti-HBc and anti-DNA, regarded as indicators of viral and pathological activity, respectively, as well as between levels of these two antibodies and the presence of HBeAg or anti-HBE as detected by radio-immune assay (RIA). In general, HBeAg-positive carriers showed high anti-HBc and high anti-DNA titers, while the carriers positive for anti-HBe had low titers of both. These findings were in accord with the histopathological results. The three serologic parameters, anti-HBc, anti-DNA, and e-antigen/antibody, should together prove useful for the evaluation of the clinical status of chronic HBsAg carriers.

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“…The presence of circulating hepatitis B e antigen (HBeAg) is closely related to the number of Dane particles (3,13,19,21,22,26,27,36), DNA polymerase activity (3,13,19,22,26,27,36), and liver damage (9,11,19,26).…”

Section: Introductionmentioning

confidence: 99%

Age‐Specific Prevalence of Hepatitis B e Antigen (HBeAg) and Antibody to HBeAg (Anti‐HBe) among Asymptomatic Hepatitis B Surface Antigen (HBsAg) Carriers in Okinawa and Kyushu, Japan

Kashiwagi

Hayashi

Nomura

et al. 1986

Microbiology and Immunology

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Correlation of e Antigen, DNA Polymerase Activity, and Dane Particles in Chronic Benign and Chronic Active Type B Hepatitis Infections

Cited by 58 publications

References 16 publications

Changes in hepatitis B virus DNA polymerase in relation to the outcome of acute hepatitis type B.

Changes in hepatitis B virus DNA polymerase in relation to the outcome of acute hepatitis type B.

Anti-DNA, anti-HBc correlations with RIA-detected HBeAg and anti-HBe in chronic HBsAg carriers

Age‐Specific Prevalence of Hepatitis B e Antigen (HBeAg) and Antibody to HBeAg (Anti‐HBe) among Asymptomatic Hepatitis B Surface Antigen (HBsAg) Carriers in Okinawa and Kyushu, Japan

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