Correlation of drug release with pulmonary drug absorption profiles for nebulizable liposomal formulations

Beck-Broichsitter, Moritz; Rieger, Monika; Reul, Regina; Gessler, Tobias; Seeger, Werner; Schmehl, Thomas

doi:10.1016/j.ejpb.2012.12.003

Cited by 34 publications

(21 citation statements)

References 40 publications

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“…This increase could indicate that aggregation or accumulation can occur due to a cut‐off size of liposomes that may be extruded through the mesh during aerosolization. Utilization of different lipid mixtures may enable prolonged drug release upon pulmonary deposition, mainly for liposomes presenting higher phase transition temperatures …”

Section: Established Nebulizersmentioning

confidence: 99%

The function and performance of aqueous aerosol devices for inhalation therapy

Carvalho

McConville

2016

Journal of Pharmacy and Pharmacology

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Objectives In this review paper, we explore the interaction between the functioning mechanism of different nebulizers and the physicochemical properties of the formulations for several types of devices, namely jet, ultrasonic and vibrating-mesh nebulizers; colliding and extruded jets; electrohydrodynamic mechanism; surface acoustic wave microfluidic atomization; and capillary aerosol generation. Key findings Nebulization is the transformation of bulk liquids into droplets. For inhalation therapy, nebulizers are widely used to aerosolize aqueous systems, such as solutions and suspensions. The interaction between the functioning mechanism of different nebulizers and the physicochemical properties of the formulations plays a significant role in the performance of aerosol generation appropriate for pulmonary delivery. Certain types of nebulizers have consistently presented temperature increase during the nebulization event. Therefore, careful consideration should be given when evaluating thermo-labile drugs, such as protein therapeutics. We also present the general approaches for characterization of nebulizer formulations. Summary In conclusion, the interplay between the dosage form (i.e. aqueous systems) and the specific type of device for aerosol generation determines the effectiveness of drug delivery in nebulization therapies, thus requiring extensive understanding and characterization.

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Section: Established Nebulizersmentioning

confidence: 99%

The function and performance of aqueous aerosol devices for inhalation therapy

Carvalho

McConville

2016

Journal of Pharmacy and Pharmacology

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“…For example, vibrating-mesh technology was suitable for the aerosolization of labile proteins 32 , liposomes 33,34 and polymeric NP [9][10][11][12]18 . To achieve an efficient pulmonary deposition, the supply of respirable aerosols represents a prerequisite 4,5 .…”

Section: Discussionmentioning

confidence: 99%

Systematic aging of degradable nanosuspension ameliorates vibrating-mesh nebulizer performance

Dalla-Bona

Schmehl

Gessler

et al. 2014

Drug Development and Industrial Pharmacy

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“…Liposomes can be prepared with a range of size and layers and will encapsulate both hydrophobic and hydrophilic drugs [8][9][10][11][12][13].…”

Section: Liposomesmentioning

confidence: 99%

Hydrogels for Controlled Pulmonary Delivery

2013

Ther. Deliv.

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A significant number of research articles have focused on pulmonary delivery as an alternative administration route owing to no first-pass metabolism, low protease activity, thin epithelium barrier and large surface area in the lung system. Controlled release in the pulmonary delivery system further reduces loading dose, frequency of dosing and systemic side effects, and also increases duration of action and patient compliance. Compared with other microparticles used in controlled-release pulmonary administration, hydrogels (3D polymeric matrix networks) have recently been investigated due to their swelling and mucoadhesive properties that could help bypass pulmonary delivery barriers. This review introduces controlled-release drug delivery to the lung, followed by a summary of currently available approaches for controlled-release pulmonary drug delivery. Lastly, the origin, advantages, detailed applications and concerns of hydrogels in pulmonary delivery are discussed.

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Correlation of drug release with pulmonary drug absorption profiles for nebulizable liposomal formulations

Cited by 34 publications

References 40 publications

The function and performance of aqueous aerosol devices for inhalation therapy

The function and performance of aqueous aerosol devices for inhalation therapy

Systematic aging of degradable nanosuspension ameliorates vibrating-mesh nebulizer performance

Hydrogels for Controlled Pulmonary Delivery

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