Hydrogels for Controlled Pulmonary Delivery

Du, Ju; Du, Ping

doi:10.4155/tde.13.90

Cited by 19 publications

(6 citation statements)

References 127 publications

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“…Nanoparticles have been suggested as a vehicle for drug delivery (Hardy et al, 2012). Slow-release hydrogels (Du et al, 2013) and carriers for the targeted delivery of aerosolized macromolecules (Osman et al, 2018) could also be investigated as future modes of serelaxin delivery. Although serelaxin has been proposed to be used as a tablet-ingested therapy for patients with fibromyalgia, it is unclear if it gets absorbed through the gut into the circulation.…”

Section: Future Directionsmentioning

confidence: 99%

Relaxin and fibrosis: Emerging targets, challenges, and future directions

Konieczko

Bennett

Samuel

et al. 2019

Molecular and Cellular Endocrinology

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The peptide hormone relaxin is well-known for its anti-fibrotic actions in several organs, particularly from numerous studies conducted in animals. Acting through its cognate G proteincoupled receptor, relaxin family peptide receptor 1 (RXFP1), serelaxin (recombinant human relaxin) has been shown to consistently inhibit the excessive extracellular matrix production (fibrosis) that results from the aberrant wound-healing response to tissue injury and/or chronic inflammation, and at multiple levels. Furthermore, it can reduce established scarring by promoting the degradation of aberrant extracellular matrix components. Following on from the review that describes the mechanisms and signaling pathways associated with the extracellular matrix remodeling effects of serelaxin (Ng et al., 2019), this review focuses on newly identified tissue targets of serelaxin therapy in fibrosis, and the limitations associated with (se)relaxin research.

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Section: Future Directionsmentioning

confidence: 99%

Relaxin and fibrosis: Emerging targets, challenges, and future directions

Konieczko

Bennett

Samuel

et al. 2019

Molecular and Cellular Endocrinology

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“…The preferred aerodynamic particle size range for deep lung delivery is around 0.5-5 μm (9). However, the conundrum is that particles within this size range are subject to rapid phagocytosis and are cleared by alveolar macrophages (10,11). To overcome the clearance due to alveolar macrophage uptake, two main approaches, larger particles with low density (12) and nanoparticles (13,14), have been explored.…”

Section: Introductionmentioning

confidence: 99%

Swellable Ciprofloxacin-Loaded Nano-in-Micro Hydrogel Particles for Local Lung Drug Delivery

El‐Sherbiny

2014

AAPS PharmSciTech

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ABSTRACT. Incorporation of drug-loaded nanoparticles into swellable and respirable microparticles is a promising strategy to avoid rapid clearance from the lung and achieve sustained drug release. In this investigation, a copolymer of polyethylene glycol grafted onto phthaloyl chitosan (PEG-g-PHCs) was synthesized and then self-assembled with ciprofloxacin to form drug-loaded nanoparticles. The nanoparticles and free drug were encapsulated into respirable and swellable alginate micro hydrogel particles and assessed as a novel system for sustained pulmonary drug delivery. Particle size, morphology, dynamic swelling profile, and in vitro drug release were investigated. Results showed that drug-loaded nanoparticles with size of 218 nm were entrapped into 3.9-μm micro hydrogel particles. The dry nano-in-micro hydrogel particles exhibited a rapid initial swelling within 2 min and showed sustained drug release. Preliminary in vivo pharmacokinetic studies were performed with formulations delivered to rats by intratracheal insufflation. Ciprofloxacin concentrations in plasma and in lung tissue and lavage were measured up to 7 h. The swellable particles showed lower ciprofloxacin levels in plasma than the controlled group (a mixture of lactose with micronized ciprofloxacin), while swellable particles achieved higher concentrations in lung tissue and lavage, indicating the swellable particles could be used for controlling drug release and prolonging lung drug concentrations.

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“…For this study, hydrogel formulations were used rather than standard microspheres due to their mucoadhesive features, which allow the spheres to penetrate barriers [ 5 ]. Additionally, the swelling properties of hydrogels reduce the possibility of macrophage clearance [ 6 ]. Hydrogels also exhibit physical properties, such as high water content and low surface tension, that are similar to those of living tissues [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…For direct pulmonary administration, many therapeutic substances, ranging from antibiotics to antibodies, have been incorporated into hydrogel systems [ 17 , 18 , 19 ]. For example, hydrogel-based particles with natural polymers, such as Zn 2+ -crosslinked alginate microparticles, for the pulmonary delivery of drugs have been previously investigated [ 6 ]. Hydrogels are considered an ideal delivery system due to their high biocompatibility, biodegradability, and low toxicity [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…This study, for the first time, explored the development of pectin-based hydrogel microspheres with a diameter of 3 μm that could be used to reach the deep parts of the lungs and how their mechanical properties and stability can be improved through coating with polymeric materials, such as gelatin. Microspheres have been widely explored as a potential vehicle for delivering drugs to the lungs through either intravenous administration or inhalation [ 6 ]. Size-based targeting of the deep alveoli has been demonstrated using biodegradable poly lactic-co-glycolic acid (PLGA) microspheres with the incorporation of dipalmitoyl phosphatidyl choline (DPPC) [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Design of Pectin-Based Hydrogel Microspheres for Targeted Pulmonary Delivery

Chai,

Schmidt,

Brewster

et al. 2023

Gels

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Pulmonary drug delivery via microspheres has gained growing interest as a noninvasive method for therapy. However, drug delivery through the lungs via inhalation faces great challenges due to the natural defense mechanisms of the respiratory tract, such as the removal or deactivation of drugs. This study aims to develop a natural polymer-based microsphere system with a diameter of around 3 μm for encapsulating pulmonary drugs and facilitating their delivery to the deep lungs. Pectin was chosen as the foundational material due to its biocompatibility and degradability in physiological environments. Electrospray was used to produce the pectin-based hydrogel microspheres, and Design-Expert software was used to optimize the production process for microsphere size and uniformity. The optimized conditions were determined to be as follows: pectin/PEO ratio of 3:1, voltage of 14.4 kV, distance of 18.2 cm, and flow rate of 0.95 mL/h. The stability and responsiveness of the pectin-based hydrogel microspheres can be altered through coatings such as gelatin. Furthermore, the potential of the microspheres for pulmonary drug delivery (i.e., their responsiveness to the deep lung environment) was investigated. Successfully coated microspheres with 0.75% gelatin in 0.3 M mannitol exhibited improved stability while retaining high responsiveness in the simulated lung fluid (Gamble’s solution). A gelatin-coated pectin-based microsphere system was developed, which could potentially be used for targeted drug delivery to reach the deep lungs and rapid release of the drug.

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Hydrogels for Controlled Pulmonary Delivery

Cited by 19 publications

References 127 publications

Relaxin and fibrosis: Emerging targets, challenges, and future directions

Relaxin and fibrosis: Emerging targets, challenges, and future directions

Swellable Ciprofloxacin-Loaded Nano-in-Micro Hydrogel Particles for Local Lung Drug Delivery

Design of Pectin-Based Hydrogel Microspheres for Targeted Pulmonary Delivery

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