Correlation of cystoscopic impression with histologic diagnosis of biopsy specimens of the bladder

Cina, Stephen J.; Epstein, Jonathan I.; Endrizzi, Joseph; Harmon, William J.; Seay, Thomas M.; Schoenberg, Mark

doi:10.1053/hupa.2001.24999

Cited by 87 publications

(48 citation statements)

References 11 publications

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“…However, it ensured preliminary patient stratifi cation and homogeneous groups for assessment. Additionally, the endoscopic impression is often inaccurate, 31 and erroneous tumour status assessment inevitably leads to opting for treatments with no potential value. As to the broader use of the techniques we propose, a potential weakness is that, despite evidence, urologists might be reluctant to practise additional manoeuvres for mitomycin administration.…”

Section: Discussionmentioning

confidence: 99%

Electromotive instillation of mitomycin immediately before transurethral resection for patients with primary urothelial non-muscle invasive bladder cancer: a randomised controlled trial

Stasi

Valenti

Verri

et al. 2011

The Lancet Oncology

122

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SummaryBackground The clinical eff ect of intravesical instillation of chemotherapy immediately after transurethral resection of bladder tumours (TURBT) has recently been questioned, despite its recommendation in guide lines. Our aim was to compare TURBT alone with immediate post-TURBT intravesical passive diff usion (PD) of mitomycin and immediate pre-TURBT intravesical electromotive drug administration (EMDA) of mitomycin in non-muscle invasive bladder cancer.

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Section: Discussionmentioning

confidence: 99%

Electromotive instillation of mitomycin immediately before transurethral resection for patients with primary urothelial non-muscle invasive bladder cancer: a randomised controlled trial

Stasi

Valenti

Verri

et al. 2011

The Lancet Oncology

122

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“…Mutated p53 gene is a common genetic abnormality in urothelial carcinoma of the bladder. Some studies have depicted that over expression of p53 occurs in higher stages and grades of urothelial carcinoma and over expression of the p53 gene product has been reported as a marker of progression in urothelial carcinoma [6]. p63, a member of the p53 gene family, encodes multiple proteins that may either transactivate p53 responsive genes or act as a dominant-negative factor toward p53.…”

Section: Introductionmentioning

confidence: 99%

The Role of CK20, p53 and p63 in Differentiation of Some Urothelial Lesions of Urinary Bladder, Immunohistochemical Study

Raheem¹,

Saied²,

Shaer³

et al. 2014

OJPathology

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Background: Differentiation of urothelial hyperplasia, dysplasia and carcinoma in situ (CIS) may pose diagnostic difficulties. We aim to evaluate the role of CK20, p53 and p63 in differentiation of such lesions. Methods: we evaluate these markers in 213 cases of bladder lesions (14 hyperplasia, 7 dysplasia, 5 CIS, 25 noninvasive and 162 invasive urothelial carcinoma) in a retrospective study on sections from formalin-fixed, paraffin-embedded blocks. Cytoplasmic staining considered for CK20 and nuclear staining for p53 and p63. Results: CK20 was expressed in 14 out of 14 hyperplasia (4 strong, 7 moderate, 3 weak), in 7 out of 7 dysplasia (4 strong , 3 182 KeywordsUrothelial Lesions, CK20, p53, p63

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“…Furthermore, histopathological evaluation in the diagnosis of bladder cancer has certain limitations in terms of real-time differentiation of grade and stage of superficial bladder cancer, since relevant early-stage and precancerous lesions are often missed (26)(27)(28). Cystoscopic evaluation is available for papillary transitional cell carcinoma (TCC); however, it is of low diagnostic sensitivity and specificity for differentiating non-papillary TCC, particularly CIS (29)(30)(31). Urine cytology has been proven to have potential advantages for bladder CIS and high-grade neoplasms, but is of quite low sensitivity for low-grade lesions and follow-up investigations of bladder cancer (32).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of optical coherence tomography in bladder cancer patients: A systematic review and meta-analysis

Huang

Zhang

et al. 2018

mol clin onc

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Abstract.A meta-analysis was performed to evaluate the accuracy of optical coherence tomography (OCT) for diagnostic accuracy studies in bladder cancer patients. English language studies reporting the diagnostic accuracy of OCT for bladder cancer were retrieved from the PubMed, EMBASE and Cochrane Library databases in December 2014. Histopathology was a reference standard. Sensitivities, specificities, positive likelihood ratios and negative likelihood ratios were calculated, and summary receiver operating characteristic curves were drawn to determine the diagnostic accuracy of OCT. Finally, 9 eligible studies (468 patients) were included in our meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio and negative likelihood ratio of OCT were 0.96 [95% confidence interval (CI): 0.94-0.98], 0.82 (95% CI: 0.80-0.85), 6.83 (95% CI: 3.24-14.1) and 0.05 (95% CI: 0.02-0.16), respectively. The summary diagnostic odds ratio was 138.88 (95% CI: 29.63-650.89) and the overall area under the curve was 0.9735. These results suggest that OCT has excellent diagnostic performance in patients with bladder cancer and recurrent lesions.

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Correlation of cystoscopic impression with histologic diagnosis of biopsy specimens of the bladder

Cited by 87 publications

References 11 publications

Electromotive instillation of mitomycin immediately before transurethral resection for patients with primary urothelial non-muscle invasive bladder cancer: a randomised controlled trial

Electromotive instillation of mitomycin immediately before transurethral resection for patients with primary urothelial non-muscle invasive bladder cancer: a randomised controlled trial

The Role of CK20, p53 and p63 in Differentiation of Some Urothelial Lesions of Urinary Bladder, Immunohistochemical Study

Diagnostic accuracy of optical coherence tomography in bladder cancer patients: A systematic review and meta-analysis

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