Correlation of cord blood bilirubin and neonatal hyperbilirubinemia in healthy newborns

Pahuja, Mayank; Dhawan, Sanju; Chaudhary, Sanjata Roy

doi:10.18203/2349-3291.ijcp20162367

Cited by 9 publications

(7 citation statements)

References 8 publications

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“…Similar findings were noted by Awasthi et al 8 and Alpay et al 11 In our study, mean cord blood albumin of babies who developed neonatal hyperbilirubinemia which required treatment was 2.28 (SD 0.32) mg/ dL, similar to the finding of Aiyappa et al 12 On ROC curve analysis, the cord blood albumin cut-off point to predict subsequent neonatal hyperbilirubinemia was <2.4 mg/dL. Pahuja et al 13 noted that the predictive value of cord albumin for development of neonatal hyperbilirubinemia was 75%, which implied a fair predictive value of the criteria, with 61.3% sensitivity and 76.8% specificity, and was in agreement with our study. Thakur P et al 14 found 4% incidence of neonatal hyperbilirubinemia at cord blood albumin level cut-off of <2 mg/dL, with specificity of 98.23%.…”

Section: Discussionsupporting

confidence: 91%

Cord blood bilirubin, albumin, and bilirubin /albumin ratio for predicting subsequent neonatal hyperbilirubinemia

Bhat¹,

Sheikh²,

Ara³

2019

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Background Early discharge of healthy term newborns after delivery has become a common practice, because of medical and social reasons, as well as economic constraints. Thus, the recognition, follow-up, and early treatment of jaundice has become more difficult as a result of early discharge from the hospital. Since the dreaded complication of neonatal hyperbilirubinemia is kernicterus, an investigation which can predict the future onset of neonatal pathological jaundice is needed. Objective To investigate the predictability of neonatal hyperbilirubinemia by using cord blood bilirubin, albumin and bilirubin/albumin ratio. Methods This study was conducted on 300 healthy newborns. Umbilical cord blood was used to measure albumin and bilirubin. All infants were regularly followed up to 5th day of life. Neonates were divided into two groups: group A was consisted of neonates who developed jaundice which was in physiological range, while group B was consisted of neonates who developed neonatal hyperbilirubinemia (requiring phototherapy or other modality of treatment). Babies suspected to have bilirubin level which cross physiological limit on any day after birth were subjected to serum bilirubin measurement. Infants whose serum bilirubin level measurement revealed bilirubin levels crossing physiological values were sent to nursery for phototherapy. Results The incidence of neonatal hyperbilirubinemia was 11%. Statistically significant correlations between cord blood bilirubin, albumin, and bilirubin/albumin ratio to the development of neonatal hyperbilirubinemia were observed. On ROC analysis, cut-off points to predict significant hyperbilirubinemia in newborn were cord blood bilirubin >3 mg/dL (sensitivity 60.61%, specificity 97.63%), albumin <2.4 mg/dL (sensitivity 78.79%, specificity 98.13%), cord blood bilirubin/albumin ratio >0.98 (sensitivity 78.79%, specificity 95.51%). Conclusion Cord blood total bilirubin, albumin. and bilirubin/albumin ratio are excellent parameters to predict the occurrence of neonatal hyperbilirubinemia. However, cord blood albumin is better compared to cord blood bilirubin and bilirubin/albumin ratio.

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Section: Discussionsupporting

confidence: 91%

Cord blood bilirubin, albumin, and bilirubin /albumin ratio for predicting subsequent neonatal hyperbilirubinemia

Bhat¹,

Sheikh²,

Ara³

2019

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“…6 Pahuja M et al in their had noted that predictive value of cord albumin for development of neonatal hyperbilirubinemia was 75% which implies a fair predictive value of the criteria with 61.3% sensitive and 76.8% specific and is incorrelation with the present study. 16 A study by Nahar et al showed cord bilirubin level >2.5 mg/dl had a sensitivity of 77%, specificity of 98.6% with negative predictive value of 96% which is in correlation with the present study. 17 Sahu et al, showed that 70% newborn who developed significant Neonatal hyperbilirubinemia had cord albumin level <2.8 gm/dL, 30% newborn had cord albumin level 2.9-3.3 gm/dL and none of the newborns with cord albumin level >3.4 gm/dL developed hyperblirubinemia.…”

Section: Figure 1: Association Between Cord Albumin Level and Neonatasupporting

confidence: 90%

Cord blood albumin as a predictor of neonatal hyperbilirubinemia in healthy neonates

Aiyappa

Shriyan

Raj

2017

Int J Contemp Pediatr

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Background: Neonatal jaundice or icterus neonatrum has been observed in newborn babies for many centuries. The objective of this study was to determine the correlation between cord albumin levels and development of hyperbilirubinemia in term healthy neonates.Methods: A prospective study was conducted on 165 term healthy neonates. Gender, gestational age, anthropometric measurements were taken into consideration. It was ascertained that there was no other risk factor for hyperbilirubinemia amongst the neonates. The neonates were divided into two groups A and B based on the cord albumin levels of <2.8 gm/dl and >2.8 gm/dl.Results: Of the 165 babies included in the study, 126 babies were under Group 1 and 39 under Group 2. 44 babies (34%) in group 1 and 28 babies (71.7%) in group 2 (p<0.0005) developed clinical icterus of which 16 in group 1 and 19 in group 2 required phototherapy (p<0.05). 1 baby in group required exchange transfusion. The sensitivity and specificity of cord albumin in detecting neonatal hyperbilirubinemia in this study was determined to be 71.8% and 65.1% respectively.Conclusions: Cord albumin levels help to determine and predict the possibility of hyperbilirubinemia among neonates. Hence this can help to identify the at-risk neonates. So, routine determination of cord albumin can be advocated to keep a track on at risk neonates.

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“…Serum BR levels can be used to assess liver function and identify liver diseases such as cirrhosis, acute or chronic hepatitis, cholestasis, primary cancer, hemolytic anemia, and pancreatic cancer [14]. Moreover, abnormal metabolism of BR, especially in newborns, may cause jaundice [15]. In the past few years, a number of BR detection methods have been developed, including those based on enzymatic assays, fluorescence, capillary electrophoresis, high-performance liquid chromatography, chemiluminescence, and piezoelectricity [16,17].…”

Section: Introduction mentioning

confidence: 99%

Luminescent sensing film based on sulfosalicylic acid modified Tb(III)-doped yttrium hydroxide nanosheets

Yang

Zheng

et al. 2018

J Adv Ceram

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Sulfosalicylic acid (SSA) was used as an intercalation agent and an excellent antenna to synthesize layered rare-earth hydroxide (LRH) materials and directly obtain SSA-modified terbium-doped ytterbium hydroxide nanosheets by mechanical exfoliation. The crystal structure and morphologies of the LRHs and nanosheets were determined by X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. The particle size and zeta potential of the prepared nanosheets were also analyzed. The as-prepared nanosheets exhibited excellent luminescent properties. The positively charged nanosheets were electrophoretically deposited on a conductive glass to form a thin film. The luminescence of this thin film can be quenched by chromate (CrO 4 2-) and bilirubin (BR), which shows good sensing properties. The quenching mechanism of the sensing film by CrO 4 2and BR was discussed based on the spectra and structure of the film.

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Correlation of cord blood bilirubin and neonatal hyperbilirubinemia in healthy newborns

Cited by 9 publications

References 8 publications

Cord blood bilirubin, albumin, and bilirubin /albumin ratio for predicting subsequent neonatal hyperbilirubinemia

Cord blood bilirubin, albumin, and bilirubin /albumin ratio for predicting subsequent neonatal hyperbilirubinemia

Cord blood albumin as a predictor of neonatal hyperbilirubinemia in healthy neonates

Luminescent sensing film based on sulfosalicylic acid modified Tb(III)-doped yttrium hydroxide nanosheets

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