Correlation of clinical, radiological and serum analysis of hypovitaminosis D with polycystic ovary syndrome: A systematic review and meta-analysis

Guraya, Shaista Salman; Alhussaini, Khadijah; Shaqrun, Faten M.; Alhazmi, Bashaer H.; Alkabli, Reem S.

doi:10.1016/j.jtumed.2017.02.005

Cited by 4 publications

(6 citation statements)

References 57 publications

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“…They found that increased BMI had a significant negative effect on 25OHD, but didn’t support the association between PCOS on 25OHD ( 33 ). Some studies showed convincing data that low 25OHD levels were associated with obesity and IR, but not with PCOS per se ( 26 , 32 , 33 ), which was consistent with our outcome.…”

Section: Discussionsupporting

confidence: 92%

“…Recently, a retrospective cross-sectional study involving Chinese with PCOS also discovered that the low level of 25OHD was prevalent in PCOS women ( 31 ). On the contrary, a systematic review and meta-analysis found that lower concentrations of serum 25OHD lead to a greater risk of developing PCOS ( 32 ). Besides, Panidis D et al.’s study grouped the patients with PCOS and controls according to BMI ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

“…Many published articles ( 38 ) suggested the association of vitamin D deficiency and IR. It cannot be ignored is that most existing studies emphasized vitamin D played a significant role in the pathogenesis of IR ( 32 ), but the pathological mechanism of IR effect on vitamin D is not yet clear. Meanwhile, obesity and IR (even in the absence of obesity) are common and important feature of PCOS ( 39 , 40 ).…”

Section: Discussionmentioning

confidence: 99%

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Polycystic ovary syndrome and 25-hydroxyvitamin D: A bidirectional two-sample Mendelian randomization study

Zhang

Yan²,

Zhao³

et al. 2023

Front. Endocrinol.

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BackgroundAccumulating observational studies have indicated that vitamin D deficiency (serum 25-hydroxyvitamin D (25OHD) < 50 nmol/L) is common in women with polycystic ovary syndrome (PCOS). However, the direction and causal nature remain unclear. In this study, we aimed to investigate the causal association between PCOS and 25OHD.MethodsA bidirectional two-sample Mendelian randomization (MR) study was used to evaluate the causal association between PCOS and 25OHD. From the publicly available European-lineage genome-wide association studies (GWAS) summary statistics for PCOS (4,890 cases of PCOS and 20,405 controls) and 25OHD (n = 417,580), we selected 11 and 102 single nucleotide polymorphisms (SNPs) as instrumental variables (IVs), respectively. In univariate MR (uvMR) analysis, inverse-variance weighted (IVW) method was employed in the primary MR analysis and multiple sensitivity analyses were implemented. Additionally, a multivariable MR (mvMR) design was carried to adjust for obesity and insulin resistance (IR) as well.ResultsUvMR demonstrated that genetically determined PCOS was negatively associated with 25OHD level (IVW Beta: -0.02, P = 0.008). However, mvMR found the causal effect disappeared when adjusting the influence of obesity and IR. Both uvMR and mvMR analysis didn’t support the causal effect of 25OHD deficiency on risk of PCOS (IVW OR: 0.86, 95% CI: 0.66 ~ 1.12, P = 0.280).ConclusionOur findings highlighted that the casual effect of PCOS on 25OHD deficiency might be mediated by obesity and IR, and failed to find substantial causal effect of 25OHD deficiency on risk of PCOS. Further observational studies and clinical trials are necessary.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Polycystic ovary syndrome and 25-hydroxyvitamin D: A bidirectional two-sample Mendelian randomization study

Zhang

Yan²,

Zhao³

et al. 2023

Front. Endocrinol.

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“…Additionally, symptomatology includes increased body weight and significant manifestations of depression or anxiety [ 4 ]. Deficiency of vitamin D has also been identified in PCOS patients, which may partly explain the hormonal and metabolic dysregulation seen in PCOS [ 5 ]. Vitamin D plays an important role in calcium homeostasis, which is crucial for the growth and development of young patients with PCOS [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Optimizing Dietary Habits in Adolescents with Polycystic Ovary Syndrome: Personalized Mediterranean Diet Intervention via Clinical Decision Support System—A Randomized Controlled Trial

Foscolou,

Papandreou,

Gioxari

et al. 2024

Children

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The hypothesis of this randomized controlled trial was that a clinical decision support system (CDSS) would increase adherence to the Mediterranean diet (MD) among adolescent females with polycystic ovary syndrome (PCOS). The objective was to assess the impact of personalized MD plans delivered via a CDSS on nutritional status and psychological well-being. Forty adolescent females (15–17 years) with PCOS were randomly assigned to the MD group (n = 20) or the Control group (n = 20). The MD group received personalized MD plans every 15 days via a CDSS, while the Control group received general nutritional advice. Assessments were conducted at baseline and after 3 months. Results showed significantly increased MD adherence in the MD group compared to the Control group (p < 0.001). The MD group exhibited lower intakes of energy, total fat, saturated fat, and cholesterol, and higher intakes of monounsaturated fat and fiber (p < 0.05). Serum calcium and vitamin D status (p < 0.05), as well as anxiety (p < 0.05) were improved. In conclusion, tailored dietary interventions based on MD principles, delivered via a CDSS, effectively manage PCOS in adolescent females. These findings highlight the potential benefits of using technology to promote dietary adherence and improve health outcomes in this population. ClinicalTrials.gov registry: NCT06380010.

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“…7 A significant number of women with polycystic ovary syndrome (PCOS) experience a deficiency in vitamin D. According to studies, between 67% and 85% of women with PCOS have low levels of 25-hydroxy vitamin D (25OHD), with concentrations below 20ng/ml. 8 Studies suggest that diminished quantities of 25OHD are connected to heightened insulin resistance, and administering vitamin D may ameliorate insulin resistance and insulin production in overweight females with polycystic ovary syndrome (PCOS). Moreover, insufficiency of vitamin D is correlated with disturbances in calcium levels, which may result in the halt of follicle development in females with PCOS.…”

Section: Introductionmentioning

confidence: 99%

Association of Vitamin D Deficiency in Pakistani Women with Polycystic Ovarian Syndrome

Siddique,

Ahuja,

Baloch

et al. 2023

PJMHS

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Objective: Females suffering from polycystic ovarian syndrome have an increased likelihood of experiencing a deficiency in vitamin D. Methods: The Obstetrics and Gynecology department at Indus Medical College Tando Muhammad Khan, conducted a cross-sectional study for six months. The study aimed to investigate 160 women aged 17–44 who presented with the polycystic ovarian syndrome. The researchers collected blood samples from the participants and measured their vitamin D levels. If the serum levels of 25-hydroxyvitamin D3 were less than 20ng/ml, the participants were considered vitamin D deficient. The researchers obtained written informed consent from all participants and used SPSS version 20 to enter and analyze the collected data. Results: The study included patients aged between 17 and 44 years old, with an average age of 25.721 ± 7.56 years. The majority of patients (n=118, 73.7%) fell within the 17-30 age range, while 52 patients (26.0%) were between the ages of 32-45. In the study group, 74 patients (46.25%) were classified as obese. However, there was no significant contrast in the occurrence of vitamin D insufficiency among different age brackets (17-30 vs. 31-44 years) or body mass index classifications (overweight vs. non-overweight). Specifically, the percentages were 57.6% vs. 57.1% for age categories and 64.8% vs. 52.3% for body mass index divisions, correspondingly, with p-values of 0.643 and 0.045. Conclusion: Among females with polycystic ovary syndrome (PCOS), the prevalence of insufficient levels of vitamin D was determined to be 58.0%. Nonetheless, there were no significant differences in the occurrence of vitamin D insufficiency across different age and BMI groups. Keywords: Vitamin D deficiency, polycystic ovarian syndrome, obesity

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Correlation of clinical, radiological and serum analysis of hypovitaminosis D with polycystic ovary syndrome: A systematic review and meta-analysis

Cited by 4 publications

References 57 publications

Polycystic ovary syndrome and 25-hydroxyvitamin D: A bidirectional two-sample Mendelian randomization study

Polycystic ovary syndrome and 25-hydroxyvitamin D: A bidirectional two-sample Mendelian randomization study

Optimizing Dietary Habits in Adolescents with Polycystic Ovary Syndrome: Personalized Mediterranean Diet Intervention via Clinical Decision Support System—A Randomized Controlled Trial

Association of Vitamin D Deficiency in Pakistani Women with Polycystic Ovarian Syndrome

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