Correlation of circulating betatrophin concentrations with insulin secretion capacity, evaluated by glucagon stimulation tests

Tokumoto, Shinsuke; Hamamoto, Yoshiyuki; Fujimoto, Kanta; Yamaguchi, Eriko; Okamura, Emiko; Honjo, Sachiko; Ikeda, Hiroki; Wada, Yoshiharu; Hamasaki, Akihiro; Koshiyama, Hiroyuki

doi:10.1111/dme.12696

Cited by 20 publications

(21 citation statements)

References 14 publications

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“…Betatrophin positively correlated with age in the controls and with HbA1c in type 2 diabetes patients [21,22]. In addition, plasma betatrophin concentrations in diabetes patients were positively correlated with duration of Type 2 diabetes and negatively correlated with increments of C-peptide concentration and creatinine clearance [40]. However, one recent study showed betatrophin and irisin were not associated with β-cell function in previously diagnosed T2DM patients [41].…”

Section: Discussionmentioning

confidence: 96%

Dynamic Changes of Betatrophin and Its Potential Effect on β-cells in Spontaneously Developed or Streptozocin-induced Diabetes Monkeys

Liu¹,

Wang²,

Wang³

2016

J Diabetes Metab

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Effects of betatrophin on β-cell proliferation and insulin secretion have been reported controversially in rodent studies. This study was to investigate the dynamic changes of betatrophin and its potential effect on β-cell function in non-human primates (NHPs). Blood betatrophin levels in naturally developed diabetes cynomolgus monkeys (n=65) significantly correlated with their body weights and blood glucose levels in the females (n=20) and with insulin and C-peptide levels in the males (n=45). Liver expression of betatrophin mRNA was markedly higher in spontaneously developed diabetes monkeys than in normoglycemic ones. Its liver expression correlated well with islet size and insulin content in normoglycemic cynomolgus monkeys and also well in spontaneously hyperglycemic (>200 mg/ dL) cynomolgus monkeys with high blood insulin level, but not well in those with very low blood insulin content. Both blood glucose and betatrophin increased dramatically in normoglycemic rhesus monkeys (n=7) after streptozocin (STZ) administration. Blood insulin initially increased on day 1 after STZ dosing and then decreased dramatically. Two NHPs with blood glucose back to ~80 mg/mL on day 14 after STZ injection showed recovery of insulin secretion. In another two STZ-treated NHPs with blood glucose >250 mg/dL, apparent proliferation of both β-cells and non-β-cells was observed in their islets. The rest NHPs with more completed β-cell destruction after STZ dosing showed much higher blood glucose (>300 mg/dL) with very low insulin and no obvious β-cell proliferation. Our results indicate that NHP liver expresses abundant betatrophin mRNA. As its levels correlated well with islet size and insulin content in some diabetic NHPs, it might play a role in β-cell proliferation. Our data are consistent with the clinical finding of the elevation of circulating betatrophin in patients with type 2 diabetes. In addition, betatrophin-enhanced β-cell proliferation seems requiring a minimal base level of pancreatic β-cells and islets.

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Section: Discussionmentioning

confidence: 96%

Dynamic Changes of Betatrophin and Its Potential Effect on β-cells in Spontaneously Developed or Streptozocin-induced Diabetes Monkeys

Liu¹,

Wang²,

Wang³

2016

J Diabetes Metab

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“…However, there was no correlation between betatrophin and fasting glucose, insulin, HbA1c, TAGs, total cholesterol or LDL-C [67]. In T2DM, many investigators showed that level of betatrophin was positively correlated with age [60,68], diabetes duration [62,68], HbA1c [56,58,60], total cholesterol and LDL-C [59,65], HDL-C [59,63], TAGs [60], BMI in female only [61], glucose [60,66], and HOMA-IR [57,59]. Contrarily, Abu-Farha et al (2015) found a negative correlation between betatrophin and total cholesterol and LDL-C [62].…”

Section: Discussionmentioning

confidence: 99%

Circulating Betatrophin and Hepatocyte Growth Factor in Type 2 Diabetic Patients: Their Relationship With Disease Prognosis

Alduraywish

2017

J Endocrinol Metab

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Background: In Saudi Arabia, diabetes established itself as an epidemic that necessitates dissection of its predisposing factors and pathogenesis to set appropriate preventive measures. In a cross-sectional study, relationships between plasma betatrophin (BetaT) and hepatocyte growth factor (HGF) on one side, and, glycemic control, lipogram, anthropometric indices, treatment and prognosis on the other side were assessed in Saudi patients with type 2 diabetes mellitus (T2DM) vs. healthy controls.

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“…However, this observation was not present in T2D patients [15]. In other studies, serum betatrophin concentrations inversely correlated with the increment of C-peptide in the glucagon stimulation test in T2D patients [21]. This might indicate that the increase in serum betatrophin concentrations is a result of insulin resistance observed in obese nondiabetic subjects.…”

Section: Introductionmentioning

confidence: 86%

Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome

Adamska

Łebkowska

Jacewicz

et al. 2017

International Journal of Endocrinology

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Introduction Data underline the role of betatrophin in glucose homeostasis. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance (IR). The aim of our study was to investigate the relationship of serum betatrophin concentrations with indirect indices of IR and insulin secretion in women with PCOS, compared to the control group. Methods The study group comprised 43 women with PCOS and 16 controls. IR was assessed by HOMA-IR and Matsuda index. Insulin secretion was evaluated with HOMA-B. An oral glucose tolerance test (OGTT) with estimation of serum betatrophin concentrations was performed. Results Glucose load resulted in an increase in serum betatrophin concentrations in the control group (p = 0.02). Serum betatrophin concentrations at 120 min of OGTT were lower in women with PCOS than in the control group (p = 0.02). We observed positive correlations between baseline serum betatrophin concentrations and HOMA-IR (r = 0.39, p = 0.008), negative correlations with Matsuda index (r = −0.31, p = 0.004), and a positive relationship with HOMA-B (r = 0.38, p = 0.01) in women with PCOS. Multiple regression analysis revealed that HOMA-B (β = 0.47, p = 0.001) was an independent factor connected to serum betatrophin levels in PCOS. Conclusions Serum concentrations of betatrophin are connected with insulin resistance and beta cell function and did not change after glucose load in women with PCOS.

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Correlation of circulating betatrophin concentrations with insulin secretion capacity, evaluated by glucagon stimulation tests

Cited by 20 publications

References 14 publications

Dynamic Changes of Betatrophin and Its Potential Effect on β-cells in Spontaneously Developed or Streptozocin-induced Diabetes Monkeys

Dynamic Changes of Betatrophin and Its Potential Effect on β-cells in Spontaneously Developed or Streptozocin-induced Diabetes Monkeys

Circulating Betatrophin and Hepatocyte Growth Factor in Type 2 Diabetic Patients: Their Relationship With Disease Prognosis

Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome

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