Correlation of carotid intimal-medial thickness with estimated glomerular filtration rate and cardiovascular risk factors in chronic kidney disease

Abstract

Carotid intimal-medial thickness (CIMT) predicts future vascular events in the general population. However, the correlation of traditional cardiovascular risk factors and stages of chronic kidney disease (CKD) with CIMT is not studied extensively. To determine the correlation of CIMT with traditional cardiovascular risk factors like age, body mass index (BMI), dyslipidemia and various stages of CKD patients, CIMT was measured by means of high-resolution B-mode ultrasonography in 70 CKD patients and compared with the 30 healthy controls. The mean CIMT in patients was 0.86 ± 0.21 mm vs 0.63 ± 0.17 mm in healthy age- and sex-matched controls (P <0.001). There was a significant univariate positive correlation between CIMT and age (r = 0.605, P <0.001), BMI (r = 0.377, P = 0.001), total cholesterol (r = 0.236, P ≤0.018) and serum triglyceride (r = 0.387, P ≤0.001). No statistically significant correlation was found between mean CIMT and estimated glomerular filtration rate (eGFR) (r = -0.02, P = 0.30), very low-density lipoprotein and high-density lipoprotein-cholesterol. Atherosclerotic changes very well correlate with the traditional cardiovascular risk factors like age, BMI, serum total cholesterol and serum triglyceride level in CKD patients. Even though CIMT was marginally more in the late stages of CKD patients, no statistically significant correlation was found with CIMT and eGFR.

Carotid Intimal Medial Thickness (CIMT) in Patients of Chronic Kidney Disease (CKD) and its Association with CKD Staging

“…In a similar study of Chhajed et al, 8 higher prevalence of CKD among males (n=39 out of 70) with a mean age of 44.5 years (range 20-75 years) was reported. 9 In present study majority of patients had stage V CKD (67%), 21% had stage III and 14% had stage IV CKD. In the reports of Hinderliter et al nearly equal numbers had stage 3 (n = 86) and stage 4 (n = 88) CKD; 24 had stage 5 CKD.…”

“…In agreement to present study findings Chhajed et al found that mean CIMT did not directly correlate with eGFR (r = -0130, P <0.283). 9 Preston et al 15 reported that patients with stage 3 to 4 CKD had increased CIMT compared with normotensive volunteers. Lu Xia Zhang et al, 16 in their study on stage 2-3 CKD patients (i.e., mild and moderate renal insufficiency), found significantly increased CIMT in these patients and concluded that arterial change might occur in the course of CKD earlier than previously believed.…”

Factors Affecting Thickening of Carotid Intima Media Thickness in Patients with Chronic Kidney Disease

“…Chhajed et al also obtained the same results where total cholesterol (r = 0.236, p≤0.018) and serum triglycerides (r = 0.387, p ≤0.001) correlated with cIMT thickening in CKD patients. [14][15][16][17] In this study no correlation was found between hormones parathyroid with carotid intima media thickness (cIMT) thickening (p = 0.180). Research Costa et al showed different results in which the correlation between parathyroid hormone and carotid intima medi thickening was obtained…”

Relationship of Remodeling of Carotid Arteries and Left Ventricular Geometry in Patients With Chronic Glomerulonephritis

“…На развитие структурных изменений ЛЖ и СА влияют также возраст, уровень АД и масса тела, что также подтверждается в нашем исследовании. При этом существует позитивная корреляция ТИМ ОСА со степенью развития коронарного атеросклероза, и поскольку этот фактор обладает прогностической значимостью в отношении развития клинических проявлений атеросклероза, он был предложен в качестве суррогатного маркера системного атеросклероза, в том числе при ХБП [20,21].…”