Carotid Intimal Medial Thickness (CIMT) in Patients of Chronic Kidney Disease (CKD) and its Association with CKD Staging

Margekar, Venugopal; Thakur, Shilpa; Jatav, O. P.; Tiwari, Dharmendra; Gupta, Manish; Yadav, Pankaj

doi:10.21276/ijcmr.2020.7.3.6

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…Another study indicated that HT patients with CKD had significantly higher CIMT compared to HT patients without CKD (17). In contrast, Margekar et al found no significant differences in CIMT in different stages of CKD (34). In this study, we showed that CIMT is significantly and negatively correlated with GFR.…”

Section: Discussioncontrasting

confidence: 61%

Investigation of the relationship between glomerular filtration rate and aortic propagation velocity, epicardial fat thickness, and carotid intima-media thickness in chronic kidney disease patients

Özdemir¹,

Asoğlu

Aladağ

et al. 2020

Preprint

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Background: Cardiovascular disease (CVD) is the primary cause of mortality and morbidity in chronic kidney disease (CKD) patients. Aortic propagation velocity (APV), epicardial fat thickness (EFT), and carotid intima-media thickness (CIMT) measurements could provide additional information on assessing renal decline in CKD patients. The study aimed to evaluate EFT, AVP, and CIMT in CKD patients and then investigate the association among those parameters. Methods and Results: A total of 170 CKD consecutive subjects were enrolled in the study. Patients were divided into five groups according to their GFR values. Each patient underwent complete transthoracic echocardiography examination. APV, EFT and CIMT were measured for analyses. A multivariate linear regression model was used for analysis to determine the independent predictors of GFR. The lowest APV was observed in stage IV-V, and the highest APV was observed in stage I-II (p<0.001). Stage IV-V patients had the highest EFT, and stage I-II patients had the lowest EFT (p<0.001). Moreover, the lowest CIMT was observed in stage III, and the highest APV was observed in stage V (p<0.001). GFR was significantly and positively correlated with APV and negatively correlated with EFT and CIMT. In multivariate analyses, APV (OR: 0.289, p<0.001), EFT (OR: -0.135, p<0.001) and CIMT (OR: -0.388, p<0.001) were independent predictors of GFR. Conclusion: We found that APV decreased, and EFT and CIMT increased as CKD progress. The present study suggests that APV, EFT, and CIMT might be incorporated with the examination of CKD patients in daily practice.

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Section: Discussioncontrasting

confidence: 61%

Investigation of the relationship between glomerular filtration rate and aortic propagation velocity, epicardial fat thickness, and carotid intima-media thickness in chronic kidney disease patients

Özdemir¹,

Asoğlu

Aladağ

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Another study indicated that HT patients with CKD had significantly higher CIMT compared to HT patients without CKD [ 17 ]. In contrast, Margekar et al found no significant differences in CIMT at the different stages of CKD [ 34 ]. In the current study, we showed that CIMT is significantly and negatively correlated with eGFR.…”

Section: Discussionmentioning

confidence: 99%

The Association of Glomerular Filtration Rate With Echocardiographic Parameters in Chronic Kidney Disease

et al. 2021

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Background: Cardiovascular disease (CVD) is the primary cause of mortality and morbidity in chronic kidney disease (CKD) patients. Aortic propagation velocity (APV), epicardial fat thickness (EFT) and carotid intima-media thickness (CIMT) measurements could provide additional information on assessing renal decline in CKD patients. The study aimed to evaluate EFT, AVP and CIMT in CKD patients and then investigate the association among those parameters. Methods: A total of 170 CKD consecutive subjects were enrolled in the study. Patients were divided into five groups according to their estimated glomerular filtration rate (eGFR) values. Each patient underwent complete transthoracic echocardiography examination. APV, EFT and CIMT were measured for analyses. A multivariate linear regression model was used for analysis to determine the independent predictors of eGFR. Results: The lowest APV was observed in stage IV-V, and the highest APV was observed in stage I-II (P < 0.001). Stage IV-V patients had the highest EFT and stage I-II patients had the lowest EFT (P < 0.001). Moreover, the lowest CIMT was observed in stage III, and the highest CIMT was observed in stage V (P < 0.001). eGFR was significantly and positively correlated with APV and negatively correlated with EFT and CIMT. In multivariate analyses, APV (odds ratio (OR): 0.289, P < 0.001), EFT (OR:-0.135, P < 0.001) and CIMT (OR:-0.388, P < 0.001) were independent predictors of eGFR. Conclusion: We found that APV decreased, and EFT and CIMT increased as CKD progress. The present study suggests that APV, EFT and CIMT might be incorporated with the examination of CKD patients in daily practice.

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“…[12][13][14][15] It is also helpful to decide the appropriate method of treatment, either surgical or medical in patients with carotid artery stenosis. [16][17][18]…”

Section: Introductionmentioning

confidence: 99%

Evaluation of atherosclerosis in patients with chronic kidney disease by measuring carotid intima media thickness: An observational study from a tertiary care center in India

Lyngdoh¹,

Banerjee²,

Chowdhury³

et al. 2021

Asian J Med Sci

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Background: Chronic kidney disease (CKD) is associated with a substantial cardiovascular mortality and morbidity. Besides other factors, accelerated atherosclerosis plays a significant role in this. Carotid intima media thickness (CIMT) is an index of systemic atherosclerosis. By measuring the CIMT with the help of B mode ultrasound at common carotid artery, the overall atherosclerotic burden in CKD patients can be estimated. Accordingly patients at increased risk of premature mortality can be identified so that timely intervention can be taken. Aims and Objectives: The aim of the study was to measure the CIMT at the level of common carotid artery by B mode ultrasound for estimation of atherosclerotic burden in patients with CKD. Materials and Methods: It is a hospital based observational cross-sectional study involving 70 patients carried out in the department of General Medicine of Medical College and Hospital, Kolkata for a period of 1 year. Patients were selected on the basis of certain inclusion and exclusion criteria. They were evaluated based on clinical history, disease duration, physical examination findings and certain investigation parameters such as complete hemogram, renal function tests, serum potassium, lipid profile, urinalysis, urine for albumin-creatinine ratio, ultrasonography of kidney-ureter-bladder, and CIMT value as measured by B mode ultrasound of carotid artery. The data collected were analyzed with a suitable statistical analysis software package. Range, frequencies, percentage, mean, standard deviation, and P value were calculated. P<0.05 was taken as significant. Results: The study showed a strong correlation between CIMT and BMI (r=0.533, P<0.001). CIMT for serum triglyceride levels (≥150 mg/dl) were significantly (P<0.001) high in patients (mean±SD=1.45±0.559) mg/dl in comparison with serum triglyceride levels (<150 mg/dl) (0.98 ± 0.380 mg/d). Patients with high cholesterol of ≥200 mg/dl have a higher CIMT of 1.56±0.574 with P<0.001. There is statistically significant relation of LDL with respect to mean CIMT as P<0.001 at 1% level of significance. Hence, mean CIMT is more in LDL (≥130) than in LDL (<130). CIMT for HDL levels (<40 mg/dl) were high in CKD (mean=1.53±0.518 mg/dl) patients compared to HDL levels (≥40 mg/dl) (mean=10.88±0.291). It was found that mean CIMT was higher in the later stages of kidney disease (Stage 3B, 4 and Stage 5) as compared to early stages (Stages 1, 2, and 3). We also found that the Mean CIMT (1.214±0.531 was higher in patients with CKD compared to sonographically defined normal value (<0.9 mm). Hence, CKD patients who have traditional risk factors for atherosclerosis such as higher BMI, higher serum total cholesterol level, higher serum triglyceride level, higher serum LDL level, and lower serum HDL level have a higher value of CIMT. Conclusion: B-mode ultrasound is a non-invasive sensitive tool for assessment of CIMT. Since CKD is associated with accelerated atherosclerosis and subsequent increased cardiovascular mortality, this modality may help us to identify patients with atherosclerotic burden so that timely intervention can be taken to reduce future cardiovascular complications in CKD patients.

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Carotid Intimal Medial Thickness (CIMT) in Patients of Chronic Kidney Disease (CKD) and its Association with CKD Staging

Cited by 3 publications

References 12 publications

Investigation of the relationship between glomerular filtration rate and aortic propagation velocity, epicardial fat thickness, and carotid intima-media thickness in chronic kidney disease patients

Investigation of the relationship between glomerular filtration rate and aortic propagation velocity, epicardial fat thickness, and carotid intima-media thickness in chronic kidney disease patients

The Association of Glomerular Filtration Rate With Echocardiographic Parameters in Chronic Kidney Disease

Evaluation of atherosclerosis in patients with chronic kidney disease by measuring carotid intima media thickness: An observational study from a tertiary care center in India

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