Correlation of Capute Scores with CD4 Count among Human Immunodeficiency Virus-infected Children in Sanglah Hospital, Bali, Indonesia

Abstract

BACKGROUND: Cognitive, motoric, and language development in a human immunodeficiency virus (HIV)-infected child is an important issue that affects developmental milestone and quality of life. The effect of HIV infection on cognitive function must be detected early to prevent delayed cognitive, motoric, and language function.
 AIM: This study aimed to assess the correlation of cognitive scores with CD4 count among HIV-infected children in pediatrics polyclinic Sanglah Hospital, Bali.
 METHODS: This cross-sectional study recruited 68 HIV-infected children age 0–36 months old as participants. Cognitive score was assessed using Cognitive Adaptive Test/Clinical Linguistic and Auditory Milestone Scale (CAT/CLAMS) scores and HIV status, and CD4 count was obtained from the medical record.
 RESULTS: The result showed that mean of CD4 count among subject was 29.85 cells/mm3, there was positive correlation between CAT scores with CD4 count (r = 0.33, p = 0.006) and also between CLAMS scores with CD4 count (r = 0.307, p = 0.01).
 CONCLUSION: It can be concluded that CD4 count correlated with Capute scores on HIV-infected children.

Determinant Factors of Low Cognitive, Motoric and Language Performance of HIV-Infected Children

“…18 Another study by Supadma et al, 2020 also stated that there was a relationship between CD4 levels and Capute Scale values in HIV-infected children compared to children who were not infected with HIV. 19 Research by Ravindran et al, 2014 found that children with HIV tend to suffer cognitive deficits in the domains of attention, language, verbal learning and memory, visuomotor functions, fine motor performance, and executive functions. 17,20 Research by Cohen et al, 2015, stated that the cognitive performance of HIVinfected children is poor compared with healthy controls.…”