Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients

Morais, Clarice Neuenschwander Lins de; Carvalho, Bruno M.; Melo, Wlademir; Melo, Fábio Lopes de; Lopes, Edmundo Pessoa de Almeida; Domingues, Ana Lúcia Coutinho; Jucá, Norma Thomé; Martins, João Roberto Maciel; Diniz, George Tadeu Nunes; Montenegro, Sílvia Maria Lucena

doi:10.1590/s0074-02762010000400018

Cited by 13 publications

(15 citation statements)

References 40 publications

(52 reference statements)

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“…The AP enzyme is a marker serum of cholestatic abnormalities and is useful when seeking to diagnose chronic liver diseases. Morais et al (25) showed that this enzyme as an accurate marker to predict moderate and severe fibrosis in patients with hepatitis C. With regard to schistosomiasis, a study described by Leite et al (18) with 55 hepatosplenic patients, they found the prevalence of advanced fibrosis in 54.5% of patients and compared them to healthy individuals, the levels of AP presented significantly elevated (P<0.0001). Other studies with hepatosplenic patients, they showed a significant increase in serum levels of AP in relation to control groups (19,20) .…”

Section: Characteristics Of the Patientsmentioning

confidence: 97%

“…Despite the widespread use of US for diagnosing and monitoring changes caused by fibrosis, its use has some limitations, such as its low sensitivity in the initial forms of the disease; the need for a trained examiner, and the fact that it is not available at all centers, especially not those located in rural areas (17) . As a result of these US limitations, studies are emerging in an attempt to develop non-invasive methods that are capable of identifying and evaluating PPF via serum markers (6,9,16,21,25,28,30) . In Brazil, it is estimated that the Schistosomiasis mansoni affects about 2.5 to 6 million individuals, residing mainly in the Northeastern region, and approximately 5% to 10% of whom will develop the severe form of the disease (hepatosplenic) (5) .…”

Section: New Index For the Diagnosis Of Liver Fibrosis In Schistosomimentioning

confidence: 99%

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New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni

Barreto

Alecrim

Medeiros

et al. 2017

Arq. Gastroenterol.

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-Background -Periportal fibrosis is the major pathological consequence of the Schistosoma mansoni infection. Objective -To evaluate the accuracy of serum markers and to construct an index to assess fibrosis. Methods -Patients (n=116) with schistosomiasis were evaluated by ultrasound scan and measurements of serum levels of aminotransferases, γ-glutamyl transferase, alkaline phosphatase, hyaluronic acid, cytokines and platelets.

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Section: Characteristics Of the Patientsmentioning

confidence: 97%

Section: New Index For the Diagnosis Of Liver Fibrosis In Schistosomimentioning

confidence: 99%

New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni

Barreto

Alecrim

Medeiros

et al. 2017

Arq. Gastroenterol.

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“…Some experimental studies in mice model indicated that schistosome egg-induced granuloma formation and hepatic fibrosis depend markedly on cytokine regulation (de Morais et al 2010;Liang et al 2011;Shen et al 2010). However, there was no clear consensus about the pattern of cytokine production and the adjustment net.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory cytokines IFN-γ, IL-4, IL-13 and TNF-α alterations in schistosomiasis: a meta-analysis

Sun

Yang

et al. 2011

Parasitol Res

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Cytokines play an important role in the immunological pathogenesis of schistosomiasis. Schistosomiasis would be associated with an imbalance in inflammatory cytokines that leads to a decrease of T helper (Th) 1 and an increase of Th2 cytokine secretion. Corresponding data so far have been inconsistent, so we performed a meta-analysis to assess whether cytokine alterations were risk factors for schistosomiasis progression. We searched MEDLINE, EMBASE, and CNKI databases for literatures including abstracts, reviews, and reference lists. Our studies included assessment of cytokine concentrations in vivo plasma or serum and secretion of cytokines in vitro by peripheral blood leukocytes from schistosomiasis patients or infected individuals with schistosome. The prototypic Th1 and Th2 cytokines IFN-γ and interleukin (IL)-4 were assessed as well as IL-13 and tumor necrosis factor-alpha (TNF-α). The results implied that an increase occurs in TNF-α and IL-4 with schistosomiasis progression.

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“…Furthermore, the applicability of using these biomarkers in routine practice is additionally limited due to the costs of the tests and the resources required to undertake them (296,299).…”

Section: Diagnosis and Evaluation Of Schistosome-induced Liver Diseasementioning

confidence: 99%

Advances in the Diagnosis of Human Schistosomiasis

et al. 2015

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SUMMARY Schistosomiasis is a major neglected tropical disease that afflicts more than 240 million people, including many children and young adults, in the tropics and subtropics. The disease is characterized by chronic infections with significant residual morbidity and is of considerable public health importance, with substantial socioeconomic impacts on impoverished communities. Morbidity reduction and eventual elimination through integrated intervention measures are the focuses of current schistosomiasis control programs. Precise diagnosis of schistosome infections, in both mammalian and snail intermediate hosts, will play a pivotal role in achieving these goals. Nevertheless, despite extensive efforts over several decades, the search for sensitive and specific diagnostics for schistosomiasis is ongoing. Here we review the area, paying attention to earlier approaches but emphasizing recent developments in the search for new diagnostics for schistosomiasis with practical applications in the research laboratory, the clinic, and the field. Careful and rigorous validation of these assays and their cost-effectiveness will be needed, however, prior to their adoption in support of policy decisions for national public health programs aimed at the control and elimination of schistosomiasis.

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Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients

Abstract: Liver biopsy is the gold-standard method to stage fibrosis; however, it is an invasive procedure and is potentially dangerous. The main objective of this study was to evaluate biological markers, such as cytokines platelets, bilirubins (Bil)

Cited by 13 publications

References 40 publications

New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni

New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni

Inflammatory cytokines IFN-γ, IL-4, IL-13 and TNF-α alterations in schistosomiasis: a meta-analysis

Advances in the Diagnosis of Human Schistosomiasis

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