Correlation of Adiponectin and Leptin with Insulin Resistance: A Pilot Study in Healthy North Indian Population

Abstract

The increasing incidence of obesity, leading to metabolic complications is now recognized as a major public-health problem. Insulin resistance is a central abnormality of the metabolic syndrome, or syndrome X, originally hypothesized by Reaven Insulin resistance is more strongly linked to intra abdominal fat than to fat in other depots. Adipose tissue secretes numerous factors (adipokines) known to markedly influence lipid and glucose/insulin metabolism, oxidative stress, and cardiovascular integrity. Some of these adipokines have been shown to directly or indirectly affect insulin sensitivity through modulation of insulin signaling and the molecules involved in glucose and lipid metabolism. A pilot study was conducted with 80 healthy subjects who were non diabetic, non hypertensive and having no family history of hypertension, the aim was to evaluate the correlation of adiponectin and leptin levels with obesity and insulin resistance markers in healthy north Indian adult population. Serum leptin, adiponectin and insulin was estimated by sandwich ELISA method. In our study, Leptin correlated significantly with BMI (P value of 0.0000), WC (P value = 0.007), and HC (P value = 0.000). leptin showed significant positive correlation with fasting insulin (P value 0.002), post prandial insulin (P value = 0.000) and HOMA-IR (P value = 0.002). Adiponectin showed significant positive correlation with triglycerides (P value = 0.038), strong negative correlation with HDL-cholesterol (P value = 0.017). Serum concentrations of leptin are associated with central body fat distribution. Insulin resistance and adiponectin is associated with dyslipidemia and these all disorders may ultimately lead to metabolic syndrome.

Comparison of serum leptin, glucose, total cholesterol and total protein levels in fertile and repeat breeder cows

“…In the present study, there was no significant correlation between leptin and total cholesterol levels in repeat breeder and fertile cows (Table 2). Our findings were consistent with other studies conducted by Yadav et al (2011). Haluzik et al (1999) investigated the relationship between serum leptin concentrations and total cholesterol levels in patient combined with hyperlipidemia and healthy controls.…”

Hyperleptinemia - an independent predictor of metabolic syndrome in the adult population in Kerala, India

“…[7][8][9] Recent studies have reported a positive correlation of insulin resistance with leptin. 10 The five generally accepted features of metabolic syndrome are obesity, insulin resistance, dyslipidemia, impaired glucose tolerance and hypertension. Specifically, a three-fold increase in the prevalence of metabolic syndrome is associated with a two-fold increased risk of cardiovascular disease fatality, 150% increase in total mortality, and a five-fold increased risk of diabetes mellitus.…”

Correlation of Serum Adiponectin, Fasting Serum Glucose and Serum Insulin in Samples Received in a Tertiary Care Hospital in Central India

“…We also found non-significant negative correlation between adiponectin and insulin resistance. In a study done by Amita et al 27 , she also showed a non-significant negative relation of insulin resistance with adiponectin. Our findings are consistent to the findings of Matsubara 28 and Funahashi 24 who demonstrated that hypo-adiponectinemia was more intensively related to the degree of insulin resistance.…”