Correlation Between Zinc Nutritional Status with Serum Zonulin and Gastrointestinal Symptoms in Diarrhea-Predominant Irritable Bowel Syndrome: A Case–Control Study

Rezazadegan, Mahsa; Soheilipour, Maryam; Tarrahi, Mohammadali; Amani, Reza

doi:10.1007/s10620-021-07368-6

Cited by 10 publications

(6 citation statements)

References 40 publications

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“…Infant respondents experienced diarrhea for a maximum of 3 days as many as 14 respondents (13,7%). this is due to the food factor given, especially if it is given at the age of under 6 months (Rezazadegan, 2022).…”

Section: Resultsmentioning

confidence: 99%

relationship of supplementary feeding, breast milk (MP-ASI) to infants with the event of diarrhea

Anggraeni¹,

Wati²,

Nambiar³

et al. 2022

ijhs

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Background: Diarrhea is one of the causes of death in toddlers, one of the factors that causes diarrhea is MP ASI. Based on the largest proportion of diarrhea sufferers at the Baros Health Center in the last 3 months of October, November, and December, there were 87 infants aged 0-12 months, 29 infants aged 12-24 months, and 31 infants aged 25-60 months. Objective: To determine the relationship between complementary feeding and the incidence of diarrhea in infants aged 3-12 months in the working area of the Baros Public Health Center, Sukabumi City. Methods: The study used a cross-sectional population and the total sampling was 48 infants aged 3-12 months. Data processing using Chi-Square. Results: The inappropriate provision of complementary feeding to infants aged 3-12 months was 26 respondents (54.2%) and the appropriate ones were 22 respondents (45.8 %), the incidence of diarrhea in infants aged 3-12 months who had diarrhea as many as 28 respondents (58.6%) and who did not have diarrhea as many as 20 respondents (41.7%). Research shows that there is a relationship between giving complementary feeding to infants aged 3-12 months with the incidence of diarrhea with a value of 0.00 (<0.05).

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Section: Resultsmentioning

confidence: 99%

relationship of supplementary feeding, breast milk (MP-ASI) to infants with the event of diarrhea

Anggraeni¹,

Wati²,

Nambiar³

et al. 2022

ijhs

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“…In the previous study, we evaluated the correlation between zinc nutritional status with serum zonulin, as a serum marker of intestinal permeability, and gastrointestinal symptoms in IBS-D patients 27 . The findings of the present study revealed that the serum concentration of zinc was lower in patients compared to their controls.…”

Section: Discussionmentioning

confidence: 99%

Zinc nutritional status, mood states and quality of life in diarrhea-predominant irritable bowel syndrome: a case–control study

Rezazadegan

Shahdadian

Soheilipour

et al. 2022

Sci Rep

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Zinc is an important trace element for structure, and regulation in the central nervous system, as well as the gut homeostasis. There are several mental disorders associated with zinc deficiency. The relationship between zinc nutritional status with mood states and quality of life (QoL) in diarrhea-predominant irritable bowel syndrome (IBS-D) has not been studied yet. This case–control study aimed to investigate the association between zinc nutritional status with mood states and QoL in IBS-D patients. Sixty-one newly diagnosed patients with IBS-D and 61 matched healthy controls were enrolled. Dietary zinc intakes and serum zinc levels were measured. Mood states and QoL were evaluated by validated questionnaires. Logistic regression was used to estimate the odds of IBS-D in relation to zinc deficiency. Decreased serum zinc levels were observed in the IBS-D group than in the controls (p = 0.001). There were higher scores of depression (p = 0.014), anxiety (p = 0.005), and stress (p = 0.001) among IBS-D patients. Moreover, overall QoL, physical and psychological health were lower in IBS-D patients compared to the controls (p < 0.001). “Food avoidance” had the lowest, while the “relationship” had the highest score among the patients (51.09 ± 26.80 and 78.14 ± 23.30, respectively). Dietary zinc intake was positively correlated with psychological health in the controls (r = 0.295, p = 0.022) and with body image in the patients (r = 0.266, p = 0.044). According to the logistic regression, zinc deficiency was not significantly associated with odds of IBS-D. Findings show that zinc deficiency may be associated with some parameters of IBS-D. Further clinical studies are needed to explore the causal relationship between zinc status and IBS pathogenesis.

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“…Recent studies have proved that intestinal zonulin plays a crucial role in the pathomechanism of other gastrointestinal diseases [ 8 , 42 ]. Elevated zonulin levels, associated with impaired mucosal barrier functions, have been described in non-celiac gluten sensitivity (NCGD) [ 126 ], irritable bowel syndrome (IBS) [ 127 , 128 ], inflammatory bowel diseases (IBD) [ 34 , 46 , 129 ], necrotizing enterocolitis [ 130 ], neonatal gastrointestinal abnormalities [ 75 , 131 ], and environmental enteric dysfunction [ 132 , 133 ].…”

Section: Diseases Associated With Altered Zonulin Levelsmentioning

confidence: 99%

Zonulin as a Potential Therapeutic Target in Microbiota-Gut-Brain Axis Disorders: Encouraging Results and Emerging Questions

Veres-Székely

Szász

Pap

et al. 2023

IJMS

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The relationship between dysbiosis and central nervous diseases has been proved in the last 10 years. Microbial alterations cause increased intestinal permeability, and the penetration of bacterial fragment and toxins induces local and systemic inflammatory processes, affecting distant organs, including the brain. Therefore, the integrity of the intestinal epithelial barrier plays a central role in the microbiota–gut–brain axis. In this review, we discuss recent findings on zonulin, an important tight junction regulator of intestinal epithelial cells, which is assumed to play a key role in maintaining of the blood–brain barrier function. In addition to focusing on the effect of microbiome on intestinal zonulin release, we also summarize potential pharmaceutical approaches to modulate zonulin-associated pathways with larazotide acetate and other zonulin receptor agonists or antagonists. The present review also addresses the emerging issues, including the use of misleading nomenclature or the unsolved questions about the exact protein sequence of zonulin.

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Correlation Between Zinc Nutritional Status with Serum Zonulin and Gastrointestinal Symptoms in Diarrhea-Predominant Irritable Bowel Syndrome: A Case–Control Study

Cited by 10 publications

References 40 publications

relationship of supplementary feeding, breast milk (MP-ASI) to infants with the event of diarrhea

relationship of supplementary feeding, breast milk (MP-ASI) to infants with the event of diarrhea

Zinc nutritional status, mood states and quality of life in diarrhea-predominant irritable bowel syndrome: a case–control study

Zonulin as a Potential Therapeutic Target in Microbiota-Gut-Brain Axis Disorders: Encouraging Results and Emerging Questions

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