Correlation Between Third Dose of COVID-19 Vaccines and Regional Case Fatality Rates During the Omicron Wave in Korea

Jang, Young-ook; Kim, In Joong; Moon, Sung-Sil; Kim, Sun Bean; Lee, Jacob

doi:10.3346/jkms.2022.37.e347

Cited by 1 publication

(1 citation statement)

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“…The Omicron variant of COVID-19 was first reported on 9 November 2021 and has since become the dominant strain worldwide [ 20 ]. In Korea, the Omicron variant was the dominant strain from late 2021 to early 2022, peaking in March 2022 [ 21 , 22 ]. The Omicron variant of COVID-19 has an increased affinity for angiotensin-converting enzyme 2 (ACE2) receptors compared to previous variants (Alpha and Delta), resulting in high transmissibility [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Outcome and Prognosis of a Nosocomial Outbreak of COVID-19

Kim

Choi

et al. 2023

JCM

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Nosocomial coronavirus disease 2019 (COVID-19) outbreaks have been reported despite widespread quarantine methods to prevent COVID-19 in society and hospitals. Our study was performed to investigate the clinical outcome and prognosis of a nosocomial outbreak of COVID-19. We retrospectively analyzed the medical records of patients diagnosed with nosocomial COVID-19 of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) at a university teaching hospital between 1 November 2021 and 31 April 2022. Nosocomial COVID-19 was defined as a positive SARS-CoV-2 polymerase chain reaction (PCR) test result 4 or more days after admission in asymptomatic patients who had a negative SARS-CoV-2 PCR test on admission. In this study, 167 patients were diagnosed with nosocomial COVID-19 (1.14%) among a total of 14,667 patients admitted to hospital during the study period. A total of 153 patients (91.6%) survived, but 14 patients (8.4%) died. The median time between admission and COVID-19 diagnosis was 11 days, and the median duration of hospital stay was 24 days. After adjusting for other factors, no vaccination (adjusted HR = 5.944, 95% CI = 1.626–21.733, p = 0.007) and chronic kidney disease (adjusted HR = 6.963, 95% CI = 1.182–41.014, p = 0.032) were found to increase mortality risk. Despite strict quarantine, a significant number of nosocomial COVID-19 cases with a relatively high mortality rate were reported. As unvaccinated status or chronic kidney disease were associated with poor outcomes of nosocomial COVID-19, more active preventive strategies and treatments for patients with these risk factors are needed.

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Section: Introductionmentioning

confidence: 99%