Correlation between the Serum Pepsinogen I Level and the Symptom Degree in Proton Pump Inhibitor-Users Administered with a Probiotic

Igarashi, Muneki; Nagano, Jun; Tsuda, Ayumi; Suzuki, Takayoshi; Koike, Jun; Uchida, Teiji; Matsushima, Masashi; Mine, Tetsuya; Koga, Yuichi

doi:10.3390/ph7070754

Cited by 12 publications

(17 citation statements)

References 12 publications

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“…As shown in Table 3, of the 14 comparisons, 3-Gomi et al (2015) study A and Waller et al (2011) studies A and B reported significantly reduced (acid) regurgitation, and three comparisons [30][31][32] did not report any improvement. With regards to reflux or heartburn, two comparisons noted a significant improvement [22,27]. Trends for improvement were observed by [31] with the modified GSRS and by [21] with the original GSRS, but not with the FSSG questionnaire.…”

Section: Resultsmentioning

confidence: 93%

“…Dyspepsia-related symptoms improved or declined in five comparisons: Gomi et al (2015) study A and [21,[28][29][30]. One study reported increased symptoms for dyspepsia [22], and three studies found no difference [31][32][33].…”

Section: Resultsmentioning

confidence: 99%

“…The synergistic effects of these mechanisms can alleviate visceral hypersensitivity and improve the interactions between luminal contents and host esophageal epithelium in GERD. Lactobacillus gasseri LG21 has been shown to increase pepsinogen (PGI), which may contribute to improved digestion and shortened gastric residence time [22]. This indicates that there are potential mechanisms for the benefits of probiotics in GERD.…”

Section: Aim Of the Studymentioning

confidence: 99%

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Gastroesophageal Reflux Disease and Probiotics: A Systematic Review

Cheng

Ouwehand

2020

Nutrients

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Probiotic is little known for its benefits on upper gastrointestinal health. The objective of this systematic review was to examine the efficacy of probiotics in alleviating the frequency and severity of symptoms in gastroesophageal reflux disease (GERD) in the general adult population. The PubMed and Web of Science databases were searched for prospective studies on GERD, heartburn, regurgitation, and dyspepsia, without any limitation on sample size. The Jadad scale was used to evaluate the quality of randomized controlled trials. In total, 13 prospective studies that were published in 12 articles were included in the analysis and scored per the Jadad scale as high- (five studies), medium- (two), and low- (six) quality. One article reported on two probiotic groups; thus, 14 comparisons were included in the selected studies, of which 11 (79%) reported positive benefits of probiotics on symptoms of GERD. Five out of 11 positive outcomes (45%) noted benefits on reflux symptoms: three noted reduced regurgitation; improvements in reflux or heartburn were seen in one study; five (45%) saw improvements in dyspepsia symptoms; and nine (81%) saw improvements in other upper gastrointestinal symptoms, such as nausea (three studies), abdominal pain (five), and gas-related symptoms (four), such as belching, gurgling, and burping. In conclusion, probiotic use can be beneficial for GERD symptoms, such as regurgitation and heartburn. However, proper placebo-controlled, randomized, and double-blinded clinical trials with a sufficient number of participants are warranted to confirm its efficacy in alleviating these symptoms. Further, interventions with longer durations and an intermediate analysis of endpoints should be considered to determine the proper therapeutic window.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Aim Of the Studymentioning

confidence: 99%

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Gastroesophageal Reflux Disease and Probiotics: A Systematic Review

Cheng

Ouwehand

2020

Nutrients

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“…; Igarashi et al . ), and these finding could account for the histopathological changes induced by nicotine in the gastric mucosa.…”

Section: Discussionmentioning

confidence: 75%

Effects of different routes of nicotine administration on gastric morphology and hormonal secretion in rats

Ali

Hamed

Ayuob

et al. 2015

Experimental Physiology

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New Findings r What is the central question of this study? Does chronic administration of nicotine by different routes affect gastric hormonal secretions and morphology in rats?r What is the main finding and its importance?Chronic nicotine administration increased levels of gastrin, ghrelin and histamine but decreased prostaglandin E 2 . Nicotine administered orally and by inhalation had a marked negative impact on the histological structure of the gastric mucosa compared with intraperitoneal administration. The negative impact of nicotine administration on gastric structure was associated with an increased concentration of gastrin and decreased prostaglandin E 2 , which might be the cause of gastric/peptic ulcers in heavy smokers. The increase in ghrelin concentration and its effect following chronic nicotine administration needs further investigation.The aim was to assess the effects of different routes of chronic nicotine administration on gastric morphology and hormonal secretion; mainly gastrin, ghrelin, histamine and prostaglandin E 2 (PGE 2 ). Forty adult male albino rats were randomly assigned into four groups (10 rats per group), treated for 21 days as follows: control group (given standard rat pellets and water only); oral nicotine-treated group [50 µg (ml drinking water)−1 ]; intraperitoneal nicotine-treated group [0.5 mg (kg body weight)−1 ]; and inhaled nicotine-treated group [0.5 mg (kg body weight)−1 ]. Concentrations of gastrin, ghrelin, PGE 2 and histamine in serum and gastric tissue homogenates were assessed using ELISA kits. Stomach fundus was processed for histopathology and immunohistochemistry using light and electron microscopy. Different routes of chronic nicotine administration resulted in a significant increase in serum and gastric homogenate gastrin and ghrelin concentrations and a significant decrease in serum and homogenate PGE 2 concentrations compared with the control group. Moreover, nicotine administration via oral and inhalation routes caused gastric erosion, transformation of peptic cells into the mucous variety, a significant increase in parietal cell numbers and an increase in expression of gastrin. In conclusion, the negative impact of nicotine administration on gastric structure that is associated with an increased concentration of gastrin and decreased concentration PGE 2 might be the leading cause of gastric/peptic ulcers in heavy smokers. The increased ghrelin concentration and

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“…The emergence of pathological gastroesophageal reflux is largely dependent on the disturbed motility of the stomach and duodenum [13,14], while the infection and eradication of Helicobacter Pylory do not play an important role in the genesis of GERD, which is also noted in the 4 Maastricht consensus. In addition, the discoordination of the motor-evacuator function of the upper parts of the gastrointestinal tract, in particular the stomach, is the basis for the appearance of mixed (duodenal refluxes), due to the imbalance in the contractile activity of the antral and pyloric divisions and the duodenum [15,16].…”

Section: Discussionmentioning

confidence: 99%

The Role of Pepsinogenes and Some Intestinal Hormones in Pathogenesis of Gastroesophageal Reflux Disease

Boichuk

2018

EUREKA: Health Sciences

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80 patients with gastroesophageal reflux disease (GERD) were examined. The diagnosis of GERD was based on the history of the disease, complaints of patients, the results of daily monitoring of pH in the lower third of the esophagus, data of fibroesophagogastroduodenoscopy, chromoendoscopy, 13C-octanoic breath test, gastrin-17 (G-17) concentration, pepsinogens I and II (P I and II) and cholecystokinin-pancreozymin (C-P) in serum. After 24 hours pH monitoring of the lower third of the esophagus in 40 patients with GERD, the predominance of acid was found, and the other 40 patients had mixed refluxes. In patients with predominance of acid reflux, the mean values of half-life of solid food evaluation (T1/2) according to 13C-octanoic breath test was (45.25±1.34) min. With the predominance of mixed refluxes in patients, there was a tendency towards hypokinetic motility of the stomach, indicating a slowdown in half-life of solid food evaluation from the stomach up to (139.24±11.87) min. With the predominance of acid reflux also was observed a significant reduction in the concentration of G-17 and C-P, an increase in P I and a decrease in the concentration of P II. Hypergastrinemia, high levels of C-P and P II (37.44±3.41) μg/l (p<0,05) were diagnosed with the predominance of mixed refluxes. Keywords: gastroesophageal reflux disease, 24 hours pH monitoring of the lower third of the esophagus, 13C-octanoic breath test, gastropanel, cholecystokinin-pancreozymin.

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Correlation between the Serum Pepsinogen I Level and the Symptom Degree in Proton Pump Inhibitor-Users Administered with a Probiotic

Cited by 12 publications

References 12 publications

Gastroesophageal Reflux Disease and Probiotics: A Systematic Review

Gastroesophageal Reflux Disease and Probiotics: A Systematic Review

Effects of different routes of nicotine administration on gastric morphology and hormonal secretion in rats

The Role of Pepsinogenes and Some Intestinal Hormones in Pathogenesis of Gastroesophageal Reflux Disease

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