Correlation between the presence of high-risk human papillomaviruses and Id gene expression in Syrian women with cervical cancer

Darnel, Andrew D.; Wang, D.; Ghabreau, Lina; Yasmeen, Amber; Sami, S.; Akil, Nizar; Moustafa, Ala-Eddin Al

doi:10.1111/j.1469-0691.2009.02774.x

Cited by 31 publications

(41 citation statements)

References 21 publications

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“…Similar detection rates of these two HPV types have been reported from Saudi Arabia [16], Algeria [17] and Mozambique 71.7% [18]. On the other hand, the prevalence of HPV 16 and HPV 18 in the previous study from Syria was 88.6% (39/44) and the prevalence of all the 7 types detected in that study was 95.45% [10]. In addition, reports from different geographical regions showed different prevalence rates for HPV 16 and 18 such as in Malaysia [19], Sudan [20] and Uganda [21].…”

Section: Resultssupporting

confidence: 60%

“…These incidence rates differ from the rates reported by Darnel et al [10] which were 47.7% and 40.9% for HPV 16 and HPV 18 respectively. However, the distribution of these two HPV types in our study is quite similar to a report from Iran which showed HPV 16 and HPV18 prevalence of 60% and 22.2% respectively [23].…”

Section: Resultscontrasting

confidence: 56%

“…There is only one study about the prevalence of HPV in cervical cancer in Syrian women, which investigated the presence of 7 Highrisk HPV types including HPV 16 and 18 in 44 cervical cancer samples which were not classified histologically [10]. Therefore, further studies with a larger number of samples are required to investigate the HPV prevalence in Syria.…”

Section: Resultsmentioning

confidence: 99%

“…There are only a few studies on the HPV prevalence and genotype distribution in Syria [10,11], therefore more studies are needed to describe the distribution of HPV genotypes in cancer cases before these data can be generalised for application in national cancer screening and prevention strategies. The main aim of this study was to assess the prevalence of HPV infections and type distribution among the female population living in Aleppo, Syria and to investigate the impact of these infections on the development of diverse histological types of cervical carcinoma.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Human Papilloma Virus Types 16 and 18 Among Women With Cervical Cancer in Aleppo, Syria

Dandal

Abajy

Alkhalaf

et al. 2017

Int J Pharm Pharm Sci

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Objective: Cervical cancer is the second common type of cancer among women worldwide. Infection by certain types of human papillomavirus infection (HPV) such as HPV 16/18 has been considered as the most significant risk factor for the development of cervical cancer. This study was conducted to determine the prevalence HPV 16/18 in women with and without cervical cancer in Aleppo city, Syria.Methods: Paraffin embedded cervical tissue samples were collected from 113 patients and 40 controls (normal cervix), DNA was extracted and analyzed by PCR for the presence of HPV16/18. Out of 113 cases of cervical carcinoma, 25 cases (22.1%) were carcinoma in situ (CIS), 72 cases (63.7%) were squamous cell carcinomas (SCC) and 16 cases (14.2%) were adenocarcinoma (ADC).Results: HPV 16 and/or 18 DNA was detected in 84 (74.3%) cases out of 113 of cervical cancers, while it was found in only two of the 40 samples in the control group. At the same time, 9 out of 25 (36%) carcinoma in situ, 61 out of 72(84.72%) squamous cell carcinomas, and 14 out of 16 (87.5%) adenocarcinomas, were positive for HPV 16 and/or 18. Conclusion:The frequency of infection with HPV 16 and 18 is high among Syrian women and a vaccine against these two types may be effective in about 74% of cervical cancers in Syria.

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Section: Resultssupporting

confidence: 60%

Section: Resultscontrasting

confidence: 56%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of Human Papilloma Virus Types 16 and 18 Among Women With Cervical Cancer in Aleppo, Syria

Dandal

Abajy

Alkhalaf

et al. 2017

Int J Pharm Pharm Sci

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“…Thus, ID1 regulates the effects of transcription factors on target genes. Infection by high-risk human papilloma viruses (HPVs) is considered to be the central cause of invasive cervical cancer, suggesting that high-risk HPVs can enhance the progression of human cervical cancer through ID1 regulation (Darnel et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

ANXA1Ac2-26 peptide reduces ID1 expression in cervical carcinoma cultures

Prates

Franco-Salla

Santos

et al. 2015

Gene

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Cervical cancer is the second most frequent cancer in women worldwide and is associated with genetic alterations, infection with human papilloma virus (HPV), angiogenesis and inflammatory processes. The idea that inflammation is involved in tumorigenesis is supported by the frequent appearance of cancer in areas of chronic inflammation. On the other hand, the inflammatory response is controlled by the action of anti-inflammatory mediators, among these mediators, annexin A1 (ANXA1), a 37 kDa protein was detected as a modulator of inflammatory processes and is expressed by tumor cells. The study was carried out on the epithelial cancer cell line (SiHa) treated with the peptide of annexin A1 (ANXA1Ac2-26). We combined subtraction hybridization approach, Ingenuity Systems software and quantitative PCR, in order to evaluate gene expression influenced by ANXA1. We observed that ANXA1Ac2-26 inhibited proliferation in SiHa cells after 72h. In these cells, 55 genes exhibited changes in expression levels in response to peptide treatment. Six genes were selected and the expression results of 5 up-regulated genes (TPT1, LDHA, NCOA3, HIF1A, RAB13) and one down-regulated gene (ID1) were research by real time quantitative PCR. Four more genes (BMP4, BMPR1B, SMAD1 and SMAD4) of the ID1 pathway were investigated and only one (BMPR1B) shows the same down regulation. The data indicate the involvement of ANXA1Ac2-26 in the altered expression of genes involved in tumorigenic processes, which could potentially be applied as a therapeutic indicator of cervical cancer.

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2-Hydroxycinnamaldehyde inhibits the epithelial-mesenchymal transition in breast cancer cells

Ismail

Kang

Lee

et al. 2013

Breast Cancer Res Treat

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Since epithelial-mesenchymal transition (EMT) plays a critical role in cancer progression and in maintaining cancer stem cell properties, EMT is emerging as a therapeutic target for inhibiting the metastatic progression of cancer cells. 2'-Hydroxycinnamaldehyde (HCA) and its derivative, 2'-benzoyloxycinnamaldehyde, have recently been suggested as promising therapeutic candidates for cancer treatment. The purpose of this study is to investigate the anti-metastatic effect of HCA on breast cancer and the molecular mechanisms by which HCA regulates the transcriptional program during EMT. HCA induces epithelial reversion at nanomolar concentrations by suppressing Snail via the nuclear translocalization of GSK-3β, which results in the transcriptional upregulation of E-cadherin. HCA also activates the transcription factor KLF17, which suppresses Id-1, indicating that HCA inhibits EMT by multiple transcriptional programs. Further, HCA treatment significantly inhibits lung metastasis in a mouse orthotopic breast cancer model. This study demonstrates the anti-metastatic effect of the non-toxic natural compound HCA through attenuation of EMT in a breast cancer model.

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Correlation between the presence of high-risk human papillomaviruses and Id gene expression in Syrian women with cervical cancer

Cited by 31 publications

References 21 publications

Prevalence of Human Papilloma Virus Types 16 and 18 Among Women With Cervical Cancer in Aleppo, Syria

Prevalence of Human Papilloma Virus Types 16 and 18 Among Women With Cervical Cancer in Aleppo, Syria

ANXA1Ac2-26 peptide reduces ID1 expression in cervical carcinoma cultures

2-Hydroxycinnamaldehyde inhibits the epithelial-mesenchymal transition in breast cancer cells

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