2-Hydroxycinnamaldehyde inhibits the epithelial-mesenchymal transition in breast cancer cells

Ismail, Ismail Ahmed; Kang, Hye Sook; Lee, Heon-Jin; Chang, Hyeyoun; Yun, Jieun; Lee, Chang Woo; Kim, Nam Hee; Kim, Hyun Sil; Yook, Jong In; Hong, Sangjin; Kwon, Byoung‐Mog

doi:10.1007/s10549-012-2388-7

Cited by 37 publications

(31 citation statements)

References 49 publications

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“…Cinnamaldehyde inhibited phosphorylation of phospholipase Cγ1 (PLCγ1) [17] and ERK1/2 [18]. Not only cinnamaldehyde, also its derivatives have diverse biological activities [35][36][37][38][39][40]. In particular, phydroxycinnamic acid, 4-hydroxy-3-methoxycinnamaldehyde and α-bromo-4-chlorocinnamaldehyde have the immunomodulatory effects in mammalian cells [36,37,39].…”

Section: Discussionmentioning

confidence: 99%

Cinnamaldehyde derivatives inhibit degranulation and inflammatory mediator production in rat basophilic leukemia cells

Ahn

Kim

Lee

et al. 2016

International Immunopharmacology

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Section: Discussionmentioning

confidence: 99%

Cinnamaldehyde derivatives inhibit degranulation and inflammatory mediator production in rat basophilic leukemia cells

Ahn

Kim

Lee

et al. 2016

International Immunopharmacology

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“…The effect of paclitaxel on cell viability was then measured using MTT assay as previously described . MCF‐7 and MDA‐MB‐231 cells were plated into 96‐well dishes at a proper cell number (5000 cells/well).…”

Section: Methodsmentioning

confidence: 99%

“…The effect of paclitaxel on cell migration of MDA‐MB‐231 breast cancer cells was investigated using the wound healing method as previously shown . In brief, MDA‐MB‐231 cells were cultured in 10 CM cell culture plates and left in the incubator.…”

Section: Methodsmentioning

confidence: 99%

“…It is reported that, DJ‐1 increased breast cancer metastasis through inhibiting its downstream target KLF17 . KLF17 is anti‐metastatic protein, and its inhibition promotes breast cancer metastasis through increasing ID‐1 protein expression since KLF17 as a transcription factor acts as a negative regulator of breast cancer metastasis by repressing ID‐1 promoter …”

Section: Introductionmentioning

confidence: 99%

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Low doses of Paclitaxel repress breast cancer invasion through DJ‐1/KLF17 signalling pathway

Ismail

El‐Sokkary

Saber

2018

Clin Exp Pharma Physio

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Paclitaxel (taxol) is an important agent against many tumours, including breast cancer. Ample data documents that paclitaxel inhibits breast cancer metastasis while others prove that paclitaxel enhances breast cancer metastasis. The mechanisms by which paclitaxel exerts its action are not well established. This study focuses on the effect of paclitaxel, particularly the low doses on breast cancer metastasis and the mechanisms that regulate it. Current results show that, paclitaxel exerts significant cytotoxicity even at low doses in both MCF-7 and MDA-MB-231 cells. Interestingly, paclitaxel significantly inhibits cell invasion and migration, decreases Snail and increases E-cadherin mRNA expression levels at the indicated low doses. Furthermore, paclitaxel-inhibiting breast cancer metastasis is associated with down-regulation of DJ-1 and ID-1 mRNA expression level with a concurrent increase in KLF17 expression. Under the same experimental conditions, paclitaxel induces KLF17 and concurrently represses ID-1 protein levels. Our results show for the first time that paclitaxel inhibits breast cancer metastasis through regulating DJ-1/KLF17/ID-1 signalling pathway; repressed DJ-1 and ID-1 and enhanced KLF17 expression.

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“…Epithelial-mesenchymal transition (EMT) plays a critical role in cancer progression and in maintaining cancer stem cell properties and hence is emerging as a therapeutic target for inhibiting the progression of cancer cells. Recent studies by Ismail et al [46], have investigated the role of 2'-Hydroxycinnamaldehyde, a compound originally isolated from cruciferous vegetables, in suppressing breast cancer metastasis by nuclear translocalization of GSK-3β via modulating Snail, which results in the transcriptional up-regulation of E-cadherin [46]. Curcumin, a natural compound extracted from Curcuma longa, an ingredient in Indian food preparations, has been shown to limit the metastatic potential of adenocarcinoma cell lines by shifting the expression of adhesion molecules and the organization and stiffness of the cell cytoskeleton [47].…”

Section: Bioactive From Fruits and Vegetables For Breast Cancer Managmentioning

confidence: 99%

Approaches in the Chemoprevention of Breast Cancer

Kelly¹

2013

J Cancer Sci Ther

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Nanotechnology in bioscience and therapeutics has advanced tremendously in this decade. Many nanoparticle formulations as well as passive and active targeted agents have been developed and proved effective preclinically in proof-of-concept models of different cancers.Many of these formulations use polymer nanoparticles, liposomes, bubkyballs, fullerenes, carbon nanotubes, dendrimers, isotope tags, and PEG compounds. In effect, nanoparticle formulations have become the norm in chemoprevention. In this paper we review nanoformulations of bioactive compounds that have been tested for their potential mechanistic antiproliferative activity in breast cancer. We also discuss the possibility of enhancing the activity of these compounds using different innovative bioconjugation methods. Citation: Dileep KV, Kelly M, Hardin E, Sadasivan C, Nair HB (2013) Approaches in the Chemoprevention of Breast Cancer. J Cancer Sci Ther 5: 282-288. doi:10.4172/1948-5956.1000217 Volume 5 number of bound reporter metal atoms per vesicle and decrease dosage without compromising signal intensity. Adding specific targeted moieties to the liposomes also could improve the targeting of contrast agents designed for breast cancer imaging. Another research group has recently reported monoclonal antibody to 2C5 (mAb2C5) that can specifically detect tumor cells, leaving the normal cells behind [9]. It is claimed that these liposomes are capable of specifically delivering diagnostic moieties to various tumors with short image acquisition time. Another group has showed PEGylated immunoliposomes labeled with 99 Tc, surface conjugated with F fragment of GAH mAb, could target human gastric cancer in a murine model [10]. Some other studies investigating immunotargeted liposomes for MR imaging enhanced their contrast using gadopentetate dimeglumine (Gd-complex) [11]. MRI signal amplification is also achieved by combining PAP and Gd moietiesin mAb2C5-modified antibodies [12]. Superior in vivo tumor accumulation of mAb2C5 in mouse models of murine Lewis lung carcinoma has been achieved by modified PAP-containing pegylated liposomes, enabling faster detection of the solid tumors [13]. Use of primary and secondary antibodies for increasing the contrast has also been tested. Typically in this inverse imaging technique, patients will receive first antitumor antibody systemically for tumor imaging. This is followed by a second antibody, encapsulated in liposomes directed against the first antibody, which enhances reticuloendothelial (RES) clearance of the first antibody, enabling distinction between normal and tumor tissues [14]. This technology has stability issues with its secondary antibody and needs to be further refined for clinical diagnostic use. Approaches in the Chemoprevention of Breast Cancer Journal ofQuantum dots: Quantum dots (QD) became powerful tools to improve molecular imaging and diagnostics as a result of their unique photophysical properties [15][16][17]. The unique features of QD are resistance to photo bleaching high signal ...

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2-Hydroxycinnamaldehyde inhibits the epithelial-mesenchymal transition in breast cancer cells

Cited by 37 publications

References 49 publications

Cinnamaldehyde derivatives inhibit degranulation and inflammatory mediator production in rat basophilic leukemia cells

Cinnamaldehyde derivatives inhibit degranulation and inflammatory mediator production in rat basophilic leukemia cells

Low doses of Paclitaxel repress breast cancer invasion through DJ‐1/KLF17 signalling pathway

Approaches in the Chemoprevention of Breast Cancer

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