Correlation between the pathology and clinical presentations in patients with adenoid cystic carcinoma of the external auditory canal

Liu, Hongyan; Zhang, Hongjie; Zhang, Ting; Li, Feitian; Dai, Chenyang

doi:10.1002/hed.24915

Cited by 14 publications

(11 citation statements)

References 14 publications

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“…In our study, the most common symptom was otalgia (82.4%), which was consistent with the works of literature. 2 , 4 , 10 , 11 Other symptoms included hearing loss, EAC mass, otorrhea, and aural fullness. In this case, patients who complained of consistent otalgia with or without mass in the cartilaginous segment of the EAC should order temporal bone MRI with enhancement to rule out ACC in the EAC.…”

Section: Discussionmentioning

confidence: 99%

The Study on Prognosis in Patients with Adenoid Cystic Carcinoma of the External Auditory Canal

Wang¹,

Li²,

Guo³

et al. 2023

Int Adv Otol

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Background: Adenoid cystic carcinoma of the external auditory canal is a rare primary malignancy, and surgery is the primary management strategy. This study aims to optimize management strategies and improve prognosis of adenoid cystic carcinoma of the external auditory canal. Methods: Seventeen patients with adenoid cystic carcinoma of external auditory canal who had been admitted to a single institution from January 2008 to March 2019 were recruited and retrospectively reviewed. Among patients with T1 tumors, 2 underwent local external auditory canal resection, 1 received lateral temporal bone resection + superficial parotidectomy. Among patients with T2 tumors, all 5 patients underwent lateral temporal bone resection + superficial parotidectomy. Among patients with T3 tumors, 3 underwent subtotal temporal bone resection + superficial parotidectomy, 2 underwent subtotal temporal bone resection + superficial parotidectomy + radiotherapy, and 1 underwent extended temporal bone resection + superficial parotidectomy + radiotherapy. Among patients with T4 tumors, 2 underwent subtotal temporal bone resection + superficial parotidectomy and 1 underwent extended temporal bone resection + total parotidectomy + radiotherapy. Results: The common manifestations included otalgia (82.4%), hearing loss (23.5%), external auditory canal mass (23.5%), otorrhea (17.6%), and aural fullness (5.9%). In the study, 5/17 (29.4%) patients had been misdiagnosed preoperatively, 5/17 (29.4%) patients revealed local recurrence, and 3/17 patients (17.6%) were identified with distant metastasis postoperatively. The 3- and 5-year overall survival rates were 88.2% and 82.3%, respectively. There was no significant difference in overall survival ( P = .746) and disease-free survival ( P = .933) between patients receiving different surgical approaches. Three out of 17 patients (17.6%) died of T2, T3, and T4 diseases, respectively. Conclusion: Otalgia is the most common manifestation of adenoid cystic carcinoma of the external auditory canal, and misdiagnosis is frequently encountered. Surgery is the preferred therapy, and local resection is associated with relapse, lateral temporal bone resection is strongly recommended in patients with early-stage tumor. Regular follow-up should be routinely conducted postoperatively to early identify local recurrence.

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Section: Discussionmentioning

confidence: 99%

The Study on Prognosis in Patients with Adenoid Cystic Carcinoma of the External Auditory Canal

Wang¹,

Li²,

Guo³

et al. 2023

Int Adv Otol

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“… 3 Adenoid cystic carcinoma is the most common malignancy of the ceruminous gland and is involved in local, perineural, and parotid gland invasion. 4 Mucoepidermoid carcinoma is a rarer malignancy of the ear canal than adenoid cystic carcinoma. The potential origin of mucoepidermoid carcinoma is the ceruminous gland; however, the actual pathogenesis is not known.…”

Section: Discussionmentioning

confidence: 99%

Ceruminous adenoma mimicking otitis externa

Tan

Çelik

2018

SAGE Open Medical Case Reports

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Ceruminous adenoma is an extremely rare condition that arises in the external auditory canal. The right ear canal in a 32-year-old man was obstructed by a ceruminous adenoma mimicking otitis externa and its symptoms. The lesion was resected under microscopic view using a transcanal approach. There were no tumor-related symptoms postoperatively and he has been disease free for 1 year after surgery.

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“…Surgery alone is usually used for T1 tumors. High rates of occult parotid involvement (59%) indicate superficial parotidectomy during the initial surgery to obtain safe surgical margins [ 64 ]. Because the incidence of nodal metastases in ACC arising in the head and neck is relatively low (5.3%), routine nodal neck dissection is not suggested in most patients [ 65 ].…”

Section: Non-squamous Cell Carcinomasmentioning

confidence: 99%

Treatment Strategies for Malignancies of the External Auditory Canal

Zhong

Zuo

2022

Curr. Treat. Options in Oncol.

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Opinion statementMalignant tumors of the external auditory canal (EAC) are rare tumors in the head and neck. Delayed diagnosis is not uncommon because the symptoms of early tumors are nonspecific. Various surgical and oncological treatment modalities have been reported. Decision-making depends on pathological feature and stage of the lesions, patient’s general condition and preference, and physician’s experience and skill. Radical surgery is widely accepted as the primary treatment of choice. Postoperative radiotherapy is used more often to improve local and regional control of the disease. Chemotherapy is usually recommended for advanced disease, residual disease, and metastasis. Prognosis is affected by multiple factors such as TNM stage, surgical margin, pathological type and differentiation of tumor, involvement of facial nerve, and so on. Although the survival rate is improved significantly over the past several decades with the development of skull base surgery, neuroradiology, anesthesiology, and oncology, it remains challenging to diagnose and treat EAC malignancies due to the rarity, the local anatomical complexity of temporal bone, and the lack of standard TNM staging system.

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Correlation between the pathology and clinical presentations in patients with adenoid cystic carcinoma of the external auditory canal

Cited by 14 publications

References 14 publications

The Study on Prognosis in Patients with Adenoid Cystic Carcinoma of the External Auditory Canal

The Study on Prognosis in Patients with Adenoid Cystic Carcinoma of the External Auditory Canal

Ceruminous adenoma mimicking otitis externa

Treatment Strategies for Malignancies of the External Auditory Canal

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