No abstract

The prognosis is suboptimal in patients with locoregionally advanced laryngeal carcinoma even after multimodality protocols. The purpose of this study was to determine the potential influential factors that have an impact on the development of locoregional recurrence, distant metastasis, and oncological outcomes in patients with locoregionally advanced laryngeal carcinoma who had surgical multimodality protocols. A sample size of 85 cases was determined based on a power of 90% and an effect size of α = 0.05. A retrospective analysis of 357 patients with a diagnosis of laryngeal cancer between 2002 and 2015 was performed. Eighteen variables based on sociodemographic, clinical, histopathological and treatment data were analyzed. Medical records of 85 consecutive patients with locoregionally advanced laryngeal carcinoma who underwent surgical multimodality protocols were reviewed. Five-year overall, disease-specific, disease-free, locoregional recurrence-free and distant metastasis-free survival were 68.7, 78.0, 69.6, 68.9 and 69.2%, respectively. Extracapsular extension was an independent predictive factor for locoregional recurrence. Pathologic tumor volume was an independent predictive factor for distant metastasis. pT-stage was an independent prognostic factor for 5-year overall survival, disease-free survival, locoregional recurrence-free survival and distant metastasis-free survival. High volume, pT4a laryngeal tumors with extracapsular extension are associated with a high risk of locoregional recurrence and distant metastasis; and have poor oncological outcomes in patients with locoregionally advanced laryngeal carcinoma treated with surgical multimodality protocols.

The epidemiology of salivary gland tumors worldwide is not very well defined. Although many studies on this subject have been undertaken, the data are generally focused on specific topics such as parotid gland neoplasms or tumors of the major salivary glands. We conducted a study to establish the prevalence and distribution of benign and malignant neoplasms of both the major and minor salivary glands at a single institution. We reviewed 244,204 cases that had come through our pathology department from January 1994 through December 2005 and found 235 cases of a salivary gland neoplasm (0.09%). The female-to-male ratio was 1.04:1, and the mean age of the patients was 47 years. Of the 235 neoplasms, 159 (67.66%) were located in the parotid gland, 34 (14.47%) in the submandibular gland, and 42 (17.87%) in the minor salivary glands. A total of 146 tumors (62.13%) were benign and 89 (37.87%) were malignant. Pleomorphic adenoma was the most common neoplasm, occurring in 98 cases (41.70%). The most common malignancy was mucoepidermoid carcinoma, with 27 cases (11.49%). Our data demonstrate that the characteristics of salivary gland tumors in a Turkish population at a single institution are similar to those reported in the literature worldwide.

No abstract

We report a case of an amebic brain abscess in a 2-year-old girl, with symptoms mimicking bacterial meningitis with no evidence of disease elsewhere. Histological evaluation of the abscess revealed the organisms, and the abscess regressed in response to specific medical treatment. This article reviews the rarity of these abscesses and difficulty in the diagnosis.

Polymorphous low-grade adenocarcinoma is a malignant epithelial tumour with low metastatic rate and infiltrative growth pattern. The palate is the most common site. Paranasal sinuses are uncommon venues for polymorphous low-grade adenocarcinoma. Here, we report a polymorphous low-grade adenocarcinoma case of the maxillary sinus, a very rare location. Although it is a low grade malignancy, progression may develop after a long time. Therefore, polymorphous low-grade adenocarcinoma should be kept in mind in the differential diagnosis even in rare sites in the head and neck. Key Words: Adenocarcinoma, Maxillary sinus, Paranasal sinuses ÖZDüşük dereceli polimorföz adenokarsinom, düşük metastaz oranı ve infiltratif büyüme paterni olan malign epitelyal bir tümördür. En sık damakta görülür. Paranazal sinüslerde çok nadirdir. Bu yazıda yerel yinelemeler gösteren nadir bir lokalizasyon olan maksiller sinüs yerleşimli bir düşük dereceli polimorföz adenokarsinom olgusu sunulmuştur. Düşük dereceli olmasına karşın, progresyon uzun zaman sonra olabilir. Bu nedenle baş boyun yerleşimli tümörlerde düşük dereceli polimorföz adenokarsinomlar ayırıcı tanıda düşünülmelidir.

No abstract

ÖzetMesanenin sarkomatoid karsinomu nadirdir ve yüksek grade'li ve ileri evre tümör-ler olarak karşımıza çıkar. Makroskopik hematüri şikayeti ile başvuran 79 yaşında erkek hastaya transüretral rezeksiyon uygulandı. Patolojik incelemelerde pansitokeratin ile epitelyal alanlarda, vimentin ile mezenkimal alanlarda difüz pozitivite gösteren tümöral alanlar izlendi. Mesanenin bu nadir neoplazisini klinik ve patolojik özellikleriyle sunmayı amaçladık. Anahtar KelimelerMesane; Sarkomatoid; Karsinom AbstractSarcomatoid carcinoma of the urinary bladder is rare and presented as a high grade and an advanced stage tumor. A 79-year old man presented with macroscopic hematuria was carried out transurethral resection. Pathological examination revealed a tumor composed of epitelial and mesenchimal areas which were showed strong positivity with pancytokeratin and vimentin, respectively. We want to present this rare neoplasm of the bladder with clinic and pathologic findings. Keywords