Correlation between the intima-media thickness of the carotid artery and aortic pulse-wave velocity in patients with type 2 diabetes. Vessel wall properties in type 2 diabetes.

Taniwaki, Hiromichi; Kawagishi, Takahiko; Emoto, Masanori; Shoji, Tetsuo; Kanda, Hiroyuki; Maekawa, Kiyoshi; Nishizawà, Yoshiki; Morii, H.

doi:10.2337/diacare.22.11.1851

Cited by 259 publications

(254 citation statements)

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“…Strong positive correlation of intima-media thickness with carotid-femoral PWV has been observed in large population cohort studies 27 and in patients with diabetes. 19,40 baPWV 16,17 was also useful to predict the early stages of atherosclerosis. 18,19 In contrast, Nishi et al 41 also observed a significant but poor correlation between baPWV and intima-media thickness in subjects with diabetes and no significant relationship with baPWV in the presence of plaques.…”

Section: Macroscopic and Microscopic Findings Of The Aortamentioning

confidence: 99%

To what extent does aortic pulse wave velocity estimate early atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits?

et al. 2011

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Pulse wave velocity (PWV), an index of arterial stiffness, is dependent not only on structural alterations in arterial wall but also on distending pressure, which could be related to wall distensibility. We investigated the efficacy of aortic PWV (AoPWV) for detecting early to moderate atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. Pressure waves were recorded at the ascending, and proximal and distal abdominal aortas in 13 male normal and KHC rabbits aged 12 months under pentobarbital anesthesia when angiotensin II or sodium nitroprusside was infused intravenously. AoPWV was compared between the two rabbit groups at different mean arterial pressure (MAP) levels. Vascular diameter (D m ) was measured using an intravascular ultrasound imaging system in the proximal thoracic and proximal abdominal aortas to determine pressure-strain elastic modulus (E p ). AoPWV was correlated to MAP in the two rabbit groups (Po0.001). AoPWV was slightly but significantly greater (o0.5 m s À1 ) in the KHC rabbit group than in the normal rabbit group at MAP level 480 mm Hg (Po0.01). The value of h/D m (h, wall thickness) was significantly high in the KHC rabbit group at any MAP level (Po0.001) in these aortic regions. There was no significant difference in E p and D m between the two rabbit groups at any MAP level. AoPWV showed only a slight but significant increase in the young KHC rabbits at different MAP levels, which was mainly due to the increased h/D m . AoPWV could underestimate aortic stiffness due to early to moderate atherosclerosis if AoPWV was adjusted for arterial pressure level.

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Section: Macroscopic and Microscopic Findings Of The Aortamentioning

confidence: 99%

To what extent does aortic pulse wave velocity estimate early atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits?

et al. 2011

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“…4 There is now established evidence that aortic stiffness increases with aging and prolonged elevation of blood pressure, 5 and is the underlying pathology of isolated systolic hypertension. 6 Aortic stiffness is closely associated with cerebral large-arterial disease involving the extracranial internal carotid [7][8][9] and intracranial large arteries. 10 It is not possible to study the direct association of aortic stiffness with changes in cerebral microvessels, which cannot be routinely assessed with current imaging technology.…”

Section: Introductionmentioning

confidence: 99%

The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients

et al. 2011

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Large-artery stiffness is a risk factor for stroke, including cerebral small-vessel disease. Retinal microvascular changes are thought to mirror those in cerebral microvessels. We investigated the relationship between aortic stiffness and retinal microvascular changes in Asian ischemic stroke patients. We studied 145 acute ischemic stroke patients in Singapore who had aortic stiffness measurements using carotid-femoral pulse wave velocity (cPWV). Retinal photographs were assessed for retinal microvessel caliber and qualitative signs of focal arteriolar narrowing, arteriovenous nicking and enhanced arteriolar light reflex. Aortic stiffening was associated with retinal arteriolar changes. Retinal arteriolar caliber decreased with increasing cPWV (r ¼ À0.207, P ¼ 0.014).After adjusting for age, gender, hypertension, diabetes, mean arterial pressure and small-vessel stroke subtype, patients within the highest cPWV quartile were more likely to have generalized retinal arteriolar narrowing defined as lowest caliber tertile (odds ratio (OR) 6.84, 95% confidence interval (CI) 1.45-32.30), focal arteriolar narrowing (OR 13.85,), arteriovenous nicking (OR 5.08, CI 1.12-23.00) and enhanced arteriolar light reflex (OR 3.83,), compared with those within the lowest quartile. In ischemic stroke patients, aortic stiffening is associated with retinal arteriolar luminal narrowing as well as features of retinal arteriolosclerosis.

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“…Considerable research has established carotid intimamedia thickness (CIMT) as a clinical surrogate marker of atherosclerosis [3]. Although pulse wave velocity values can be roughly correlated with CIMT [3], when assessing pulse wave velocity in clinical practice, confounding factors such as abnormalities of blood pressure (BP), blood flow and sympathetic tones might increase the variability of pulse wave velocity [4] that is often observed in subjects with obesity and type 2 diabetes.…”

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confidence: 99%

Leptin : adiponectin ratio as an atherosclerotic index in patients with type 2 diabetes : relationship of the index to carotid intima–media thickness

et al. 2005

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Correlation between the intima-media thickness of the carotid artery and aortic pulse-wave velocity in patients with type 2 diabetes. Vessel wall properties in type 2 diabetes.

Abstract: The results indicated that diabetic patients showed more advanced changes in atherosis than that in sclerosis as compared with age- and sex-matched control subjects. Such atherotic changes in diabetic patients may be associated with hyperlipidemia.

Cited by 259 publications

References 0 publications

To what extent does aortic pulse wave velocity estimate early atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits?

To what extent does aortic pulse wave velocity estimate early atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits?

The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients

Leptin : adiponectin ratio as an atherosclerotic index in patients with type 2 diabetes : relationship of the index to carotid intima–media thickness

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