Leptin : adiponectin ratio as an atherosclerotic index in patients with type 2 diabetes : relationship of the index to carotid intima–media thickness

The value of serum adipokine measurement in non‐alcoholic fatty liver disease

“…The rationale of the A/L ratio relies on the opposite effects and reciprocal changes of leptin and adiponectin in obesity and NAFLD. Moreover, the A/L ratio has been used in other scenarios such as type 2 diabetes, where it has potential utility as a marker of atherosclerosis (22) or as an indicator of insulin resistance (23). In their multivariate analysis, Lemoine and colleagues also found that a homeostasis model assessment score 4 3 was also independently associated with NASH and that the combination of this variable with an A/L ratio o 1.4 Â 10 3 was able to predict NASH with an area under the receiver operating characteristic curve of 0.82.…”

Association of the leptin to high-molecular-weight adiponectin ratio with metabolic syndrome

“…1 shows the different means of the leptin/HMW adiponectin ratio according to the number of metabolic It has also been recently suggested that the leptin/ adiponectin ratio may play a role as a marker for insulin resistance [23,34,35] and type 2 diabetes [36]. In addition, pulse wave velocity and carotid intima-media thickness, which are surrogate clinical markers of atherosclerosis, are also correlated with the leptin/ adiponectin ratio [37,38]. In an Aboriginal Canadian population, however, incident type 2 diabetes was borderline significant for the leptin/adiponectin ratio [39].…”

Clinical Impact of the Leptin to Soluble Leptin Receptor Ratio on Subclinical Carotid Atherosclerosis in Patients with Type 2 Diabetes

“…A few clinical studies have reported an association of plasma leptin and IMT [24][25][26][27] . In 120 healthy subjects with a wide BMI range, the IMT of the common carotid artery was positively associated with plasma leptin in both men and women, and this was independent of classical risk factors; however, the association between IMT and plasma leptin was lost after adjusting for BMI 25) .…”

“…Several case-control studies revealed that plasma leptin levels were an independent predictor of the onset of acute coronary events in the general population 16) and in men with mild hypercholesterolemia 17) , and of recurrent coronary events in patients with coronary heart disease [18][19][20] , while others did not [21][22][23] . Consensus has not been achieved regarding the association of leptin with the intima-media thickness (IMT) of the carotid artery, which is assessed by ultrasound [24][25][26][27] and which is an established surrogate marker of cardiovascular disease 28) . Furthermore, the clinical implications of plasma sOb-R levels or the free leptin index on atherosclerosis have not yet been elucidated 29) , although they have been reported to be associated with obesity, insulin resistance, and metabolic risk factors [9][10][11] .…”