Correlation between the Functional and Histological Staging of Oral Submucous Fibrosis

Shivakumar, Ganiga Channaiah; Srinath, Sahana

doi:10.5005/jp-journals-10011-1031

Cited by 7 publications

(7 citation statements)

References 9 publications

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“…The results of the present study are similar to the studies done by Kiran et al (2007), Pandya et al (2009), Goel et al (2010, Rooban et al (2005), Tupkari et al (2007) and Rajendran et al (1994) On contrary, Ceena et al (2009) and Shivakumar et al (2010) on correlating the severity of disease and degree of mouth opening found statistically significant results. The variations in the result can be due to the dependence on various other factors such as site of involvement, extent of fibrosis, involvement of underlying musculature, duration of the disease and difference in the staging system used.…”

Section: Discussionsupporting

confidence: 92%

Correlation of Habits and Clinical Findings with Histopathological Diagnosis in Oral Submucosal Fibrosis Patients

Ara¹,

Arora²,

Zakaullah³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Oral submucosal fibrosis (OSMF) is one of the most prevalent premalignant conditions in India which is easy to diagnose but difficult to manage. At present it is considered as irreversible and incurable. It has also been referred to as an epidemic in India. Aims and Objectives: To correlate the frequency and duration of habits with clinical staging, functional staging and histopathological grading and to correlate the clinical and functional staging with histopathological grading. Materials and Methods: The study included a total of 90 subjects, 80 with OSMF in the experimental group and 10 patients in the control group. Patient personal history was recorded with chewing habits, including frequency and duration of chewing. The site of keeping the quid, time duration and whether he/she swallows it or spits it were also noted. Clinical staging was done on the presence of palpable fibrous bands. Functional staging was accomplished by measuring mouth opening. Incisional biopsy was done for all the patients for histopathological examination. Histopathological grading was according to Pindborg and Sirsat. Results: The experimental group comprised 71 males and 9 females, the majority of which were in the age group of 21-30 years. Correlation of habits with clinical staging, functional staging and histopathological grading were significant (p<0.05). Clinical and functional staging did not correlate with histopathological grading, but the correlation of clinical and functional staging was highly significant (p<0.01). Conclusions: The widespread habit of chewing gutkha is a major risk factor for OSMF, especially in the younger age group. In this study, it was found that with increase in the duration and frequency of the habit the severity of the disease increased.

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Section: Discussionsupporting

confidence: 92%

Correlation of Habits and Clinical Findings with Histopathological Diagnosis in Oral Submucosal Fibrosis Patients

Ara¹,

Arora²,

Zakaullah³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…[12] The distribution of patients in the histological Group I (10%) is comparable to that of Shivakumar and Sahana[7] where 12% were in Group I. However, a wide variation is seen when other groups were compared such as Group II in the present study constitutes 20% of the participants in contrast to that by Shivakumar and Sahana[7] where it accounts for 44%.…”

Section: Discussionsupporting

confidence: 67%

“…Similar findings have been observed in the study by Khanna and Andrade[8] and Shivakumar and Sahana. [7] Studies on qualitative analysis of collagen distribution in different stages of OSMF using Picrosirius red stain under polarized microscopy by Ceena et al ,[15] Modak et al ,[16] and Radhika et al [17] found that tight packing of collagen fibers in OSMF progressively increased as the disease progressed from early to advanced stages, and it was observed that comparison of functional and histological stages was a reliable indicator of the severity of the disease than clinical staging. However, Rooban et al ,[18] Kiran Kumar et al ,[12] Goel et al ,[19] and Gajendra et al [20] in their studies did not find significant correlation between clinical staging of mouth opening and histological grading of fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“…The most frequently affected sites of OSMF occurring in the oral cavity are the buccal mucosa, retromolar area, followed by the soft palate, palatal fauces, uvula, tongue, and labial mucosa. [7] The clinical symptoms begin with burning sensation of mucosa with hot and spicy food. Excessive salivation, blisters, ulceration, and altered gustatory sensations follow soon.…”

Section: Introductionmentioning

confidence: 99%

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Assessment and correlation between functional and histological staging of oral submucous fibrosis: A clinicohistopathologic study

Bhatt¹,

Manjunath²,

Khakhla

et al. 2019

Natl J Maxillofac Surg

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Background and Objective: Oral submucous fibrosis (OSMF) is a precancerous condition. It is widespread in the Asian subcontinent, with India bearing most of the burden. It is characterized by mucosal rigidity of varying intensity due to the fibroelastic changes of the juxta epithelial layer, resulting in a progressive inability to open the mouth. Early recognition with accurate staging of the disease and appropriate treatment planning is of utmost importance to prevent the malignant transformation and to improve the quality of life of the patient. In the present study, an attempt is made to clinically evaluate the condition and correlate it with the histopathological findings according to standard criteria. Materials and Methods: A hospital-based study was conducted on sixty OSMF patients. Detailed history was recorded, and functional staging was given depending on mouth opening. Punch biopsy was performed, and histological stages were given based on standard criteria. The data so received were mathematically evaluated to determine whether any correlation exists between the stages using Chi-square test. Results: The sixty patients were in the age range of 16–50 years. Male-to-female ratio was that of 97:3. The statistical analysis using Chi-square test showed statistically significant association ( P < 0.001) between the functional and histologic stages. Conclusion: There is a definite correlation between functional and histological stages of OSMF which suggests that clinically advanced OSMF has extensive fibrosis histologically.

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“…OSMF has been reported almost exclusively among Indians living in India and among other Asians, with a reported prevalence ranging up to 0.4% in Indian rural population. [ 3 4 ]…”

Section: Introductionmentioning

confidence: 99%

Quantitative evaluation of macrophage expression using CD68 in oral submucous fibrosis: An immunohistochemical study

Pereira

Naik

Tamgadge

2015

Ann Med Health Sci Res

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Background:Macrophages are important cells for the innate immunity. Circulating monocytes are attracted to tissues by chemotactic factors and become macrophages under the influence of their microenvironment. Several studies suggested that local and systemic upregulation of fibrogenic cytokines and downregulation of antifibrotic cytokine are central to the pathogenesis of oral submucous fibrosis (OSMF). Currently, there have been no attempts made to elucidate the presence and role of macrophages in OSMF.Aim:Our aim was to study the expression of CD68 in OSMF patients and to investigate the possible correlation of macrophages using CD68 in various histopathological grades of OSMF.Subjects and Methods:A prospective case–control study which included 40 patients was conducted after obtaining informed consent and Ethical Committee clearance. Ten cases were normal control and thirty cases had OSMF. Biopsy was performed and a quantitative study of macrophages was done using CD68 antigen and was immunohistochemically localized. Statistical analysis was carried out using the Statistical Package for Social Sciences (SPSS) 17.0 version (SPSS Inc., Chicago, IL, USA).Results:OSMF was observed in male patients of a younger age group. The macrophage number in the patients of intermediate and advanced stage of OSMF was higher than that of the controls which was statistically significant (P < 0.05).Conclusion:The findings of this study suggest that CD68 plays a vital role in the pathogenesis of OSMF and can be regarded as a useful marker for assessing the progress of the disease.

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Correlation between the Functional and Histological Staging of Oral Submucous Fibrosis

Cited by 7 publications

References 9 publications

Correlation of Habits and Clinical Findings with Histopathological Diagnosis in Oral Submucosal Fibrosis Patients

Correlation of Habits and Clinical Findings with Histopathological Diagnosis in Oral Submucosal Fibrosis Patients

Assessment and correlation between functional and histological staging of oral submucous fibrosis: A clinicohistopathologic study

Quantitative evaluation of macrophage expression using CD68 in oral submucous fibrosis: An immunohistochemical study

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