Correlation between the activity of the autonomic nervous system and endothelial function in patients with acute coronary syndrome

Cieślik-Guerra, Urszula; Fila, Michał; Kamiński, Marek; Kotas, Rafał; Wróblewski, Janusz; Trzos, Ewa; Uznańska‐Loch, Barbara; Rechciński, Tomasz; Wierzbowska−Drabik, Karina; Kasprzak, Jarosław D.; Kurpesa, Małgorzata

doi:10.20452/pamw.2456

Cited by 10 publications

(8 citation statements)

References 13 publications

(14 reference statements)

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“…Pathophysiologically, insulin resistance has been associated with low-grade but persistent inflammatory response [33], which has been associated with the rupture of atherosclerotic plaques in ACS [34]. Besides, higher TyG index has also be related to endothelial dysfunction and impaired autonomic function [35,36], which were both considered as predictors of poor clinical outcomes in ACS patients [37]. Future studies are needed to determine the exact molecular mechanisms underlying the potential association between TyG index and risk of MACEs in ACS patients.…”

Section: Number Of Patientsmentioning

confidence: 99%

Triglyceride-Glucose Index Predicts Adverse Events in Patients with Acute Coronary Syndrome: A Meta-Analysis of Cohort Studies

Ren

Chang

et al. 2021

Horm Metab Res

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The triglyceride-glucose (TyG) index, a recently proposed indicator for insulin resistance, has been related with cardiovascular risks. We aimed to summarize the association between TyG index and incidence of major adverse cardiovascular events (MACEs) in patients with acute coronary syndrome (ACS). Cohort studies demonstrating the association between TyG index and incidence of MACEs in ACS patients with multivariate adjusted analyses were identified by search of PubMed, Embase, and Web of Science databases. A random-effekt model incorporating the heterogeneity was applied to pool the results. Eight cohort studies with 19 611 participants were included. Results showed that compared to those with the lowest category of TyG index, ACS patients with the highest category of TyG index were independently associated with higher risk of MACEs [risk ratio (RR): 1.94, 95% confidence interval (CI): 1.47–2.56, I2=85%, p <0.001). Subgroup analyses showed consistent results in patients with ST-segment elevated myocardial infarction or non-ST segment elevated ACS, in patients with or without diabetes, and in patients after percutaneous coronary intervention. Results were consistent in studies with TyG index analyzed as continuous variable (RR for per standard deviation increment of TyG index: 1.59, 95% CI: 1.38–1.83, I2=24%, p <0.001). In conclusion, higher TyG index may be independently associated with higher incidence of MACEs in patients with ACS.

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Section: Number Of Patientsmentioning

confidence: 99%

Triglyceride-Glucose Index Predicts Adverse Events in Patients with Acute Coronary Syndrome: A Meta-Analysis of Cohort Studies

Ren

Chang

et al. 2021

Horm Metab Res

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“…The endothelium plays an important role in the pathogenesis of ACS ( Cieslik-Guerra et al, 2014 ), and circulating endothelial cells (CECs) have been put forward as a promising biomarker for diagnosis and prognosis of coronary artery disease and ACS ( Schmidt et al, 2015 ). The increased ET-1 level in active coronary lesions may lead to vasospasm and to the progression of atherosclerosis ( Ihling, 1998 ).…”

Section: Discussionmentioning

confidence: 99%

The Therapeutic Efficacy of Danhong Injection Combined With Percutaneous Coronary Intervention in Acute Coronary Syndrome: A Systematic Review and Meta-Analysis

et al. 2018

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Background: Percutaneous coronary intervention (PCI) is widely used in treatment of acute coronary syndrome (ACS) clinically. It is believed that Danhong injection (DHI) extracted from salviae miltiorrhizae and flos carthami combined with PCI could increase the therapeutic efficacy on ACS. We provide an updated meta-analysis with detailed information on combination of DHI and PCI therapy.Materials and Methods: Electronic databases were searched for appropriate articles without language limitations on key words before October 22, 2017. All trails were screened according to certain criteria. Quality of eligible studies was also assessed. We made a detailed record of outcome measurements. RevMan 5.3 software was used to perform the meta-analysis.Results: 14 articles involving 1533 patients with ACS were selected. Compared to PCI treatment alone, total efficacy rate (TER) was enhanced and major adverse cardiovascular events (MACE) were reduced significantly for the combination of DHI and PCI (P < 0.00001). Vascular endothelial function was improved by significantly decreasing the contents of ET-1, vWF and increasing the levels of NO and FMD (P < 0.00001). The serum levels of IL-1, IL-6, IL-18, TNF-α, LpPLA2, MMP-9, and pentraxin-3 were significantly decreased (P < 0.00001), whereas IL-10 in serum was increased (P < 0.00001), indicating a stronger anti-inflammatory effect of the combination. The combination therapy decreased the serum levels of CD62P, PAGT, PADT, FIB-C significantly (P < 0.05), which was beneficial for preventing coagulation of platelets. Blood lipid was also affected by regulating TC, TG, LDL, and HDL, but the results were not statistically significant (P > 0.05). Cardiac function was improved by increasing LEVF (P = 0.006) but not LVED (P = 0.08). The combination treatment was associated with an improvement in antioxidant effect by decreasing MDA and increasing SOD significantly (P < 0.00001).Conclusion: Combination of DHI and PCI in treatment of ACS could improve TER and reduce incidence of MACE after PCI therapy. These effects may be mediated by combined actions of several mechanisms. However, these results of this study should be handled cautiously due to the limitations of this research. Several rigorous RCTs are in need to confirm these findings.

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“…Coronary artery spasm is not only observed in variant angina pectoris but also plays an important role in the pathogenesis of acute coronary syndromes (unstable angina, myocardial infarction) [3][4][5]. We proved earlier that endothelial dysfunction and coronary spasm diagnosed in acetylcholine test is observed in the majority of patients presenting with non-ST-segment elevation acute coronary syndrome [6].…”

mentioning

confidence: 81%

A response to “The importance of vasodilator therapy before or during angiography, is ICD necessary or not?” by Tamer Kırat and Nuri Köse

Chyrchel

Dziewierz

Dudek

2015

International Journal of Cardiology

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Correlation between the activity of the autonomic nervous system and endothelial function in patients with acute coronary syndrome

Cited by 10 publications

References 13 publications

Triglyceride-Glucose Index Predicts Adverse Events in Patients with Acute Coronary Syndrome: A Meta-Analysis of Cohort Studies

Triglyceride-Glucose Index Predicts Adverse Events in Patients with Acute Coronary Syndrome: A Meta-Analysis of Cohort Studies

The Therapeutic Efficacy of Danhong Injection Combined With Percutaneous Coronary Intervention in Acute Coronary Syndrome: A Systematic Review and Meta-Analysis

A response to “The importance of vasodilator therapy before or during angiography, is ICD necessary or not?” by Tamer Kırat and Nuri Köse

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