Triglyceride-Glucose Index Predicts Adverse Events in Patients with Acute Coronary Syndrome: A Meta-Analysis of Cohort Studies

Abstract

The triglyceride-glucose (TyG) index, a recently proposed indicator for insulin resistance, has been related with cardiovascular risks. We aimed to summarize the association between TyG index and incidence of major adverse cardiovascular events (MACEs) in patients with acute coronary syndrome (ACS). Cohort studies demonstrating the association between TyG index and incidence of MACEs in ACS patients with multivariate adjusted analyses were identified by search of PubMed, Embase, and Web of Science databases. A random-effekt model incorporating the heterogeneity was applied to pool the results. Eight cohort studies with 19 611 participants were included. Results showed that compared to those with the lowest category of TyG index, ACS patients with the highest category of TyG index were independently associated with higher risk of MACEs [risk ratio (RR): 1.94, 95% confidence interval (CI): 1.47–2.56, I2=85%, p <0.001). Subgroup analyses showed consistent results in patients with ST-segment elevated myocardial infarction or non-ST segment elevated ACS, in patients with or without diabetes, and in patients after percutaneous coronary intervention. Results were consistent in studies with TyG index analyzed as continuous variable (RR for per standard deviation increment of TyG index: 1.59, 95% CI: 1.38–1.83, I2=24%, p <0.001). In conclusion, higher TyG index may be independently associated with higher incidence of MACEs in patients with ACS.

Predictive effect of triglyceride-glucose index on clinical events in patients with acute ischemic stroke and type 2 diabetes mellitus

“…Recently, most studies focus on the level of TyG index in healthy and cardiovascular disease individuals to evaluate the incidence and prognosis of CAD and CVD. Some studies indicated that elevated levels of TyG index were associated with higher risk of coronary atherosclerosis progression and all-cause mortality, which was confirmed by some meta-analysis in coronary heart disease studies [ 15 , 16 ]. And, TyG index was also associated with an increased risk of stroke recurrence, all-cause mortality, and neurologic worsening in acute IS patients [ 17 , 18 ].…”

Relationship between the triglyceride-glucose index and risk of cardiovascular diseases and mortality in the general population: a systematic review and meta-analysis

“…Wang et al found that the TyG index a positive association between TyG index and hypertension risk in the general adult population [ 51 ], and Li et al demonstrated that the index can predict adverse events in patients with acute coronary syndrome [ 66 ]. Previous meta-analyses have also examined the relationship between the TyG index and the prognosis of patients with acute coronary syndromes [ 12 , 66 ]. Compared to previous meta-analysis, the population in our study was the general population.…”

Triglyceride−glucose index in the prediction of major adverse cardiovascular events in patients with type 2 diabetes mellitus after coronary artery bypass surgery: A retrospective cohort study

“…Indicating TyG index, a hematological indicator of IR that is straightforward, practical, and stable, is a reliable predictor of coronary artery disease prognosis. Others have shown that a higher TyG index is associated with an increased risk of significant adverse cardiac and cerebrovascular events in patients having a percutaneous coronary intervention for ST-elevation myocardial infarction (STEMI) ( 29 ). Although multiple recent studies have proven the association between the TyG index and vascular disease ( 30 , 31 ), no studies have examined the prognosis of diabetes patients with CABG.…”