Correlation between the ABC classification and radiological findings for assessing gastric cancer risk

Itoh, Toshihide; Saito, Miho; Marugami, Nagaaki; Hirai, Toshiko; Marugami, Aki; Takahama, Junko; Tanaka, Toshihiro; Kichikawa, Kimihiko

doi:10.1007/s11604-015-0469-3

Cited by 18 publications

(15 citation statements)

References 16 publications

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“…Recently, Itoh et al also reported the aberration of high-risk subjects in group A by using radiologic findings [18]. In the present study, in the multicenter study we conducted in Japan, we clarified that (1) some gastric cancer patients were found in group A and (2) that only approximately 7% of all gastric cancer patients in group A were regarded as H. pylori uninfected.…”

Section: Discussionsupporting

confidence: 53%

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Characteristics of gastric cancer in negative test of serum anti-Helicobacter pylori antibody and pepsinogen test: a multicenter study

et al. 2016

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Background and aim The serological risk prediction system combines the pepsinogen test and anti-Helicobacter pylori (H. pylori) antibody determination. In this system, chronic atrophic gastritis (CAG) is diagnosed using the pepsinogen test. Patients who are H. pylori negative and pepsinogen negative are classified into group A, are assumed to be H. pylori uninfected, and are at an extremely low risk for gastric cancer. However, gastric cancers are detected in this group. The aim of this study is to clarify the clinicopathological status of group A patients with gastric cancer. Methods A total of 109 gastric cancer patients classified as group A were enrolled in a multicenter study. Group A patients were divided into two subgroups: group AN (H. pylori uninfected) and group AP (H. pylori infected). They were compared to 183 H. pylori-infected gastric cancer patients who were not in group A. 123Gastric Cancer (2017( ) 20:764-771 DOI 10.1007 Results Of the 109 patients, only 7 were classified as group AN; the other 102 were classified as group AP. The clinicopathological features of group AP included older age, predominantly differentiated type cancer, endoscopically visualized CAG, and pepsinogen (PG) I/II ratio lower than that of group AN. In group AN, the depressed type was dominant, and the PG I/II ratio was higher than in those gastric cancer patients who were infected with H. pylori. Conclusion Patients in group AP had CAG, and their gastric cancers were similar to those of H. pylori-eradicated patients. Concerning the recent ABC classification system, advanced decision criteria should be proposed to decrease the false-negative evaluation of gastric cancer risk.

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Section: Discussionsupporting

confidence: 53%

“…A previous report suggested that the subjects whose anti-H. pylori antibody titers were between 3 and 9.9 should be treated as having a high risk [18]. In addition, these subjects should receive gastrointestinal endoscopic examinations.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of gastric cancer in negative test of serum anti-Helicobacter pylori antibody and pepsinogen test: a multicenter study

et al. 2016

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“…Previous studies have demonstrated the original cut-off level of PG to diagnose the presence of gastritis [12,13,14]. Accordingly, we tried to add the new criteria for diagnosing and then classifying high-risk patients into group A to obtain better accuracy as follows: (1) negative-high Hp-Ab titer (3-9.9 U/mL); (2) PG II ≥15 ng/mL; (3) PG I/PGII ≤4.0; (4) PG I ≥100 ng/mL; and (5) any of the above.…”

Section: Resultsmentioning

confidence: 99%

“…Further, we tried to add the new criteria for diagnosing and then classifying low-risk patients into group A to obtain better accuracy as follows: (1) exclude patients with negative-high Hp-Ab titer (3-9.9 U/mL) from group A [12]; (2) exclude patients with PG II ≥15 ng/mL from group A [13]; (3) change the criteria of ABC classification by PG I/PGII ≤4.0 [13]; (4) exclude patients with PG I ≥100 ng/mL from group A [14]; and (5) any of the above.…”

Section: Methodsmentioning

confidence: 99%

Serological Evaluation of Gastric Cancer Risk Based on Pepsinogen and <b><i>Helicobacter pylori </i></b>Antibody: Relationship to Endoscopic Findings

et al. 2017

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Backgrounds and Aims: The serological risk-prediction system combined the pepsinogen (PG) test, and anti-Helicobacter pylori antibody is available for evaluation of gastric cancer risk. In this system, chronic atrophic gastritis (CAG) or H. pylori infection is diagnosed. Subjects with H. pylori negative and PG test negative (group A) are supposed to be those who have never been infected with H. pylori and are at extremely low risk for gastric cancer. However, a certain proportion of patients with CAG has been identified as the extremely low-risk group (group A). Here we examined endoscopic atrophy and investigated its relationship with the ABC classification system. Methods: We examined 540 patients. All patients underwent an endoscopic examination for evaluating corpus atrophy. Fasting sera were collected and serum PGs and anti-H. pylori antibody (Hp-Ab) titer (E-plate Eiken) were evaluated. Results: Of the 540 patients, 306 were classified into group A. However, 136 of them showed signs of endoscopic atrophy (group A with CAG). Group A with CAG frequently comprised the elderly. A new titer cut-off (<3 U/mL) of the Hp-Ab improved the discrimination of group A with CAG by 8%. Conclusion: The prevalence of group A with CAG patients is a critical problem, especially in elderly subjects.

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“…KK-LC-1 may be a good candidate to help diagnose gastric cancer because of its high frequency of expression and specificity for tumors involving H. pylori infection. There is currently a risk of gastric cancer designated as the ABC(D) classification, which stratifies patients into three or four risk groups using H. pylori infection and atrophic gastritis by measuring anti-H. pylori IgG and pepsinogen I/II in serum (16). However, it is difficult to detect patients with gastric cancer even in the high-risk group (high H. pylori titer and low pepsinogen, and high or low H. pylori titer and high pepsinogen) because fewer than 3% of the tumors are detected (17).…”

Section: Figure 1 Relationship Between Anti-helicobacter Pylori Igg mentioning

confidence: 99%

Correlation Between Expression of the Cancer/Testis Antigen KK-LC-1 and Helicobacter pylori Infection in Gastric Cancer

Fukuyama

Futawatari

Ichiki

et al. 2017

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Correlation between the ABC classification and radiological findings for assessing gastric cancer risk

Abstract: A good correlation exists between ABC classifications and radiological findings for gastric cancer risk, but some discrepant cases exist. We recommend both methods as screening for gastric cancer.

Cited by 18 publications

References 16 publications

Characteristics of gastric cancer in negative test of serum anti-Helicobacter pylori antibody and pepsinogen test: a multicenter study

Characteristics of gastric cancer in negative test of serum anti-Helicobacter pylori antibody and pepsinogen test: a multicenter study

Serological Evaluation of Gastric Cancer Risk Based on Pepsinogen and <b><i>Helicobacter pylori </i></b>Antibody: Relationship to Endoscopic Findings

Correlation Between Expression of the Cancer/Testis Antigen KK-LC-1 and Helicobacter pylori Infection in Gastric Cancer

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