Correlation between Soluble IL-2 Receptor Serum Levels and Regulatory T Lymphocytes in Patients with Solid Tumors

Brivio, Fernando; Lissoni, Paolo; Fumagalli, Luca; Rovelli, F; Brivio, Rinaldo; Vigorè, L.; Messina, Giusy; Tisi, E

doi:10.1177/172460080802300209

Cited by 6 publications

(3 citation statements)

References 4 publications

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“…Treg cells are a small subset of CD4 + T cells that can be identified by constitutive expression of CD25 (the α -chain of the IL-2R), and these cells control immune responses in multiple circumstances [28, 29]. Brivio et al demonstrated a positive correlation between the serum concentration of sIL-2R and the number of Treg cells in patients with solid tumors [30]. The immunosuppressive state that occurs with enhanced Treg cell generation may be associated with an abnormally high serum sIL-2R level.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Serum Soluble T Cell Regulatory Molecules in Clear Cell Renal Cell Carcinoma

Masuda

Arai

Nishihara

et al. 2014

BioMed Research International

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To clarify the role of serum soluble T cell regulatory molecules in clear cell renal cell carcinoma (CCRCC), we measured the serum levels of soluble interleukin-2 receptor (sIL-2R), soluble B7-H3 (sB7-H3), and soluble cytotoxic T lymphocyte associated antigen-4 (sCTLA-4) in 70 CCRCC patients and 35 healthy controls. We investigated correlations between the serum levels of these soluble T cell regulatory molecules and the pathological grade, clinical stage, and prognosis of CCRCC. We also assessed the relations among each of these soluble molecules. As a result, the serum level of sIL-2R was significantly higher in CCRCC patients than in healthy controls (P < 0.05). In addition, elevation of serum sIL-2R was significantly correlated with the clinical stage (P < 0.001), and the survival of patients with high sIL-2R levels was shorter than that of patients with low sIL-2R levels (P < 0.05). Furthermore, the serum level of sB7-H3 was also significantly correlated with the clinical stage (P < 0.05), while the sIL-2R and sB7-H3 levels showed a positive correlation with each other (R = 0.550, P < 0.0001). These results indicate that the serum level of sIL-2R reflects tumor progression in CCRCC patients. In addition, the possibility was suggested that the IL-2/IL-2R and B7-H3 pathways may be involved in the progression of CCRCC.

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Section: Discussionmentioning

confidence: 99%

Clinical Significance of Serum Soluble T Cell Regulatory Molecules in Clear Cell Renal Cell Carcinoma

Masuda

Arai

Nishihara

et al. 2014

BioMed Research International

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“…In particular, cell immunity has a primary role in tumor clearance [22]. Tumors are known to induce the production of inhibitory T cells and inhibitory macrophages, which can inhibit the production of IL-2 lymphocytes and promote tumor growth [23, 24]. To a certain extent, IL-2 activity reflects the body’s immune monitoring function, and its main biological activity involves promoting the proliferation of T lymphocytes and NK cells, differentiation and proliferation of B cells, and production of antibodies, among other functions [25].…”

Section: Resultsmentioning

confidence: 99%

Optimization of the fermentation process of Cordyceps sobolifera Se-CEPS and its anti-tumor activity in vivo

Yang

Zhang

2016

J Biol Eng

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BackgroundCordyceps sobolifera (C. sobolifera) isolated from cicadae was used as the starting fungus to produce selenium-enriched C. sobolifera extracellular polysaccharide (Se-CEPS). An orthogonal experimental design based on a single-factor experiment was used to optimize the C. sobolifera fermentation conditions, including the potato juice, peptone, and KH2PO4 concentrations. Ultraviolet (UV) and infrared (IR) analyses of CEPS and Se-CEPS were conducted, as well as an in vivo anti-tumor analysis.ResultsUnder optimal conditions (i.e., 40 potato juice, 0.4 KH2PO4, and 0.5 % peptone), the fermentation yield of Se-CEPS was 5.64 g/L. UV and IR spectra showed that Se-CEPS contained a characteristic absorption peak of a selenite Se = O double bond, demonstrating the successful preparation of Se-CEPS. Activity tests showed that Se-CEPS improved the immune organ index, serum cytokine content, and CD8+ and CD4+ T lymphocyte ratio in colon cancer CT26 tumor-bearing mice, thereby inhibiting tumor growth. When combined with 5-FU, Se-CEPS reduced the toxicity and enhanced the function of 5-FU.ConclusionThe result of these experiments indicated that orthogonal experimental design is a promising method for the optimization of Se-CEPS production, and the Se-CEPS from C. sobolifera can improve the anti-tumor capacity of mice.Electronic supplementary materialThe online version of this article (doi:10.1186/s13036-016-0029-0) contains supplementary material, which is available to authorized users.

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“…Interleukin‐2 is a cytokine that regulates the activities of T cells and is released in a soluble form (sIL‐2R) by activated T cells. As interleukin‐2 signaling facilitates not only effector T cells but also inhibitory T cells, 17 higher sIL‐2R levels could equally represent an immunosuppressive tumor microenvironment. Recently, we reported that preoperative elevation in the sIL‐2R level was associated with poor survival after CN and that patients with reduced sIL‐2R level after CN showed significantly longer survival 9 .…”

Section: Discussionmentioning

confidence: 99%

Spontaneous regression of multiple pulmonary metastases accompanied by normalization of serum immune markers following cytoreductive nephrectomy in a patient with clear‐cell renal cell carcinoma

et al. 2020

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Introduction The spontaneous regression of metastases, which mostly occurs after surgical resection of the primary tumor, has been described in various malignancies, including renal cell carcinoma. The involvement of the host immune system is currently postulated as the underlying mechanism. Case presentation We present a case of metastatic clear‐cell renal cell carcinoma that achieved complete spontaneous regression of multiple pulmonary metastases preceded by normalization of serum immune markers after cytoreductive nephrectomy. The patient remained disease free for 3 years without any systemic therapy, suggesting that postoperative normalization of serum immune markers may indicate recovery of the host immune system, which prevents tumor recurrence. Conclusion Monitoring of serum immune markers may be useful to identify patients with recovered immune function and, therefore, may not require systemic therapy. Similarly, the case suggests a potential role of cytoreductive nephrectomy in the contemporary management of metastatic renal cell carcinoma.

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Correlation between Soluble IL-2 Receptor Serum Levels and Regulatory T Lymphocytes in Patients with Solid Tumors

Cited by 6 publications

References 4 publications

Clinical Significance of Serum Soluble T Cell Regulatory Molecules in Clear Cell Renal Cell Carcinoma

Clinical Significance of Serum Soluble T Cell Regulatory Molecules in Clear Cell Renal Cell Carcinoma

Optimization of the fermentation process of Cordyceps sobolifera Se-CEPS and its anti-tumor activity in vivo

Spontaneous regression of multiple pulmonary metastases accompanied by normalization of serum immune markers following cytoreductive nephrectomy in a patient with clear‐cell renal cell carcinoma

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