Correlation Between Single Nucleotide Polymorphisms of an miRNA Binding Site in the 3′UTR of<i>PTEN</i>and Risk of Cervical Cancer Among the Han Chinese

Yu, Aijun; Zhang, Jiejie; Mei, Yuxian; Zhong, Hai; Chen, Shasha; Song, Qian

doi:10.1089/gtmb.2019.0269

Cited by 5 publications

(6 citation statements)

References 21 publications

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“…The presence of SNPs in the 3′UTR region on genes involved in cancer has revealed that disruptions of the regulatory role of miRNAs can contribute to the development of cancer and autoimmune diseases ( Yu et al, 2020 ; Tchacrome et al, 2022 ) SNPs in this region have been proposed as biomarkers of prognosis, prevention ( Jeon et al, 2021 ), susceptibility and chemotherapy response ( Cipollini et al, 2014 ), or even associated with cancer risk ( Yu et al, 2020 ). The presence of multiple SNPs within this region explains, in part, the observed variability in cancer-related gene expression among patients.…”

Section: Discussionmentioning

confidence: 99%

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Impact of MICA 3′UTR allelic variability on miRNA binding prediction, a bioinformatic approach

Toledo-Stuardo,

Ribeiro,

Campos

et al. 2023

Front. Genet.

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MicroRNAs (miRNAs) are small non-coding RNAs that participate as powerful genetic regulators. MiRNAs can interfere with cellular processes by interacting with a broad spectrum of target genes under physiological and pathological states, including cancer development and progression. Major histocompatibility complex major histocompatibility complex class I-related chain A (MICA) belongs to a family of proteins that bind the natural-killer group 2, member D (NKG2D) receptor on Natural Killer cells and other cytotoxic lymphocytes. MICA plays a crucial role in the host’s innate immune response to several disease settings, including cancer. MICA harbors various single nucleotide polymorphisms (SNPs) located in its 3′-untranslated region (3′UTR), a characteristic that increases the complexity of MICA regulation, favoring its post-transcriptional modulation by miRNAs under physiological and pathological conditions. Here, we conducted an in-depth analysis of MICA 3′UTR sequences according to each MICA allele described to date using NCBI database. We also systematically evaluated interactions between miRNAs and their putative targets on MICA 3′UTR containing SNPs using in silico analysis. Our in silico results showed that MICA SNPs rs9266829, rs 1880, and rs9266825, located in the target sequence of miRNAs hsa-miR-106a-5p, hsa-miR-17-5p, hsa-miR-20a-5p, hsa-miR-20b-5p, hsa-miR-93, hsa-miR-1207.5p, and hsa-miR-711 could modify the binding free energy between −8.62 and −18.14 kcal/mol, which may affect the regulation of MICA expression. We believe that our results may provide a starting point for further exploration of miRNA regulatory effects depending on MICA allelic variability; they may also be a guide to conduct miRNA in silico analysis for other highly polymorphic genes.

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Section: Discussionmentioning

confidence: 99%

“…Frontiers in Genetics frontiersin.org with cancer risk (Yu et al, 2020). The presence of multiple SNPs within this region explains, in part, the observed variability in cancerrelated gene expression among patients.…”

Section: Figurementioning

confidence: 99%

Impact of MICA 3′UTR allelic variability on miRNA binding prediction, a bioinformatic approach

Toledo-Stuardo,

Ribeiro,

Campos

et al. 2023

Front. Genet.

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“…To date, SNPs and miRNA sequence-based variations have been applied to the prediction of tumour-associated diseases, asthma, TB, cardiovascular and cerebrovascular diseases (among others) in recent decades [14, 15]. For example, the SNP located within the 3′ untranslated region (3′ UTR) of the phosphatase and tensin homologue ( PTEN ) gene has been found to be associated with cervical cancer risk [16]. Another miRNA, miR-27a, has also been found to play key roles in regulating gene expression and proliferation of ovarian cancer and breast cancer cells [17, 18].…”

Section: Discussionmentioning

confidence: 99%

Associations of genetic variants of miRNA coding regions with pulmonary tuberculosis risk in China

et al. 2021

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Tuberculosis (TB) is the leading cause of death caused by single pathogenic microorganism of mycobacterium tuberculosis (MTB). The study aims to explore the associations of microRNA (miRNA) single nucleotide polymorphisms (SNPs) with pulmonary TB (PTB) risk. A population-based case-control study was conducted, and 168 newly diagnosed smear-positive PTB cases and 251 non-TB controls were recruited. SNPs located within miR-27a (rs895819), miR-423 (rs6505162), miR-196a-2 (rs11614913), miR-146a (rs2910164), miR-618 (rs2682818) were selected and MassARRAY® MALDI-TOF System was employed for genotyping. SPSS19.0 was adopted for statistical analysis, non-conditional logistic regression was performed. Odds ratios (ORs) and 95%confidence intervals (95%CIs) were computed to estimate the associations.Associations of haplotypes with PTB risk was performed with online tool. Rs895819 CT/CC genotype was associated with reduced PTB risk among female population (OR= 0.45, 95%CI: 0.23-0.98), p=0.045. Haplotypes (Combined with rs895819, rs2682818, rs2910164, rs6505162 and rs11614913) TCCCT, TAGCC, CCCCC, CCGCT and TCGAT were associated with reduced

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“…23,24 Recent evidence has shown that SNPs within miRNA binding sequences may affect the binding energy and expression of miRNA targets, and eventually contribute to the susceptibility of CSCC. [12][13][14][15][16] For instance, an insertion/deletion rs3783553 polymorphism in the 3ʹ-UTR of interleukin-1A was associated with a decreased risk to develop CSCC. 13 Similarly, the rs963918 C allele and rs963917 G allele in the 3ʹ-UTR of RAD51B conferred lower risks of cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9][10][11] Currently, several susceptibility factors of cervical cancer have been discovered, such as single nucleotide polymorphisms (SNPs) in the binding sites of miRNAs. [12][13][14][15][16] The SNPs may affect miRNAs binding, alter the expression of miRNAs target genes, and finally modify the risk of CSCC. 15,16 Moreover, genome wide association studies (GWAS) have identified 6p21.32 as a susceptibility locus of cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

A Functional Variant rs2072915 is Associated with the Susceptibility and Mortality of Cervical Squamous Cell Carcinoma

Li¹,

Wu²,

Guo³

et al. 2021

PGPM

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Purpose Genetic variant has been demonstrated to be a risk factor for the occurrence and outcome of cervical squamous cell carcinoma (CSCC). From previous genome wide association studies, 6p21.32 has been identified as a susceptibility locus of CSCC. The purpose of this study was to investigate the association of a polymorphism rs2072915 located in 6p21.32 with the risk of CSCC and examine the potential mechanism of the rs2072915 in CSCC pathogenesis. Patients and Methods The rs2072915 was genotyped using polymerase chain reaction (PCR)-restriction fragment length polymorphism. miR-637 and RXRB mRNA expression levels in CSCC patients were examined using quantitative PCR. miR-637 target site was determined using the dual-luciferase reporter assay. Results The rs2072915 was associated with a significantly increased risk (AA vs TT: adjusted OR = 2.48, 95% CI, 1.57–3.94, P < 0.001; AT/AA vs TT: adjusted OR = 1.38, 95% CI, 1.06–1.80, P = 0.018; A vs T: adjusted OR = 1.49, 95% CI, 1.21–1.84, P < 0.001, respectively) and shorter survival time of CSCC ( P = 0.03). Patients with the rs2072915 AA genotype displayed lower levels of RXRB that is a target of miR-637. Conclusion These findings suggest that the rs2072915 T > A change might augment the binding energy of miR-637 to RXRB , result in lower levels of RXRB , and thus contribute to the risk of CSCC.

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Correlation Between Single Nucleotide Polymorphisms of an miRNA Binding Site in the 3′UTR ofPTENand Risk of Cervical Cancer Among the Han Chinese

Cited by 5 publications

References 21 publications

Impact of MICA 3′UTR allelic variability on miRNA binding prediction, a bioinformatic approach

Impact of MICA 3′UTR allelic variability on miRNA binding prediction, a bioinformatic approach

Associations of genetic variants of miRNA coding regions with pulmonary tuberculosis risk in China

A Functional Variant rs2072915 is Associated with the Susceptibility and Mortality of Cervical Squamous Cell Carcinoma

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